Consumption and Metabolism of Extracellular Pyruvate by Cultured Rat Brain Astrocytes

Astrocyte-neuron metabolic cooperation shapes brain activity

(2021) Gilles Bonvento et al.   Cell Metabolism

Mitochondrial enzyme GPT2 regulates metabolic mechanisms required for neuron growth and motor function in vivo

(2021) Ozan Baytas et al.   HUMAN MOLECULAR GENETICS

Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply

(2021) Jens V. Andersen et al.   Molecular Brain

The role of SLC transporters for brain health and disease

(2021) Yen T. K. Nguyen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes

(2021) Liang Xu et al.   Journal of Chemical Information and Modeling

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

(2020) Robinson Arce-Molina et al.   eLife

BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control

(2020) Christopher L Axelrod et al.   EMBO Molecular Medicine

Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells

(2019) Xiaowen Guan et al.   AAPS Journal

Consequences of a Metabolic Glucose-Depletion on the Survival and the Metabolism of Cultured Rat Astrocytes

(2019) Christian Arend et al.   NEUROCHEMICAL RESEARCH

Astrocytic pyruvate carboxylation: Status after 35 years

(2019) Arne Schousboe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Development and Cell Biology of the Blood-Brain Barrier

(2019) Urs H. Langen et al.   Annual Review of Cell and Developmental Biology

The Emerging Nature of Astrocyte Diversity

(2019) Baljit S. Khakh et al.   Annual Review of Neuroscience

Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments

(2019) Yasna Contreras-Baeza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

(2018) Wusheng Xiao et al.   ANTIOXIDANTS & REDOX SIGNALING

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation

(2017) Benjamin D. Rowlands et al.   JOURNAL OF NEUROCHEMISTRY

The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

(2017) Michaela C. Hohnholt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

β-Hydroxybutyrate Boosts Mitochondrial and Neuronal Metabolism but is not Preferred Over Glucose Under Activated Conditions

(2017) Lavanya B. Achanta et al.   NEUROCHEMICAL RESEARCH

Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A

(2017) Yanmin Zhang et al.   PLANTA MEDICA

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte–neuron lactate and ketone body shuttle systems

(2016) Jonathan Thevenet et al.   FASEB JOURNAL

Mitochondrial pyruvate transport: a historical perspective and future research directions

(2015) Kyle S. McCommis et al.   BIOCHEMICAL JOURNAL

Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity

(2015) Bethany Nancolas et al.   BIOCHEMICAL JOURNAL

Neuronal Activity and Glutamate Uptake Decrease Mitochondrial Mobility in Astrocytes and Position Mitochondria Near Glutamate Transporters

(2014) J. G. Jackson et al.   JOURNAL OF NEUROSCIENCE

Imaging Mitochondrial Flux in Single Cells with a FRET Sensor for Pyruvate

(2014) Alejandro San Martín et al.   PLoS One

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate-mediated glia-neuronal signalling in the mammalian brain

(2014) F. Tang et al.   Nature Communications

Comparison of Primary and Secondary Rat Astrocyte Cultures Regarding Glucose and Glutathione Metabolism and the Accumulation of Iron Oxide Nanoparticles

(2013) Charlotte Petters et al.   NEUROCHEMICAL RESEARCH

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

(2013) Brandon M. Kenwood et al.   Molecular Metabolism

Malate–aspartate shuttle and exogenous NADH/cytochrome c electron transport pathway as two independent cytosolic reducing equivalent transfer systems

(2012) Daniela Isabel Abbrescia et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cerebrospinal fluid lactate and pyruvate concentrations and their ratio

(2012) Wan-Ming Zhang et al.   CLINICAL BIOCHEMISTRY

Substrate Competition Studies Demonstrate Oxidative Metabolism of Glucose, Glutamate, Glutamine, Lactate and 3-Hydroxybutyrate in Cortical Astrocytes from Rat Brain

(2012) Mary C. McKenna   NEUROCHEMICAL RESEARCH

Metabolism, Compartmentation, Transport and Production of Acetate in the Cortical Brain Tissue Slice

(2012) Caroline Rae et al.   NEUROCHEMICAL RESEARCH

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons

(2010) Nader D. Halim et al.   GLIA

Protection by pyruvate against glutamate neurotoxicity is mediated by astrocytes through a glutathione-dependent mechanism

(2010) Yifeng Miao et al.   MOLECULAR BIOLOGY REPORTS

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

(2009) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

The cytosolic redox state of astrocytes: Maintenance, regulation and functional implications for metabolite trafficking

(2009) Johannes Hirrlinger et al.   BRAIN RESEARCH REVIEWS