Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

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Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

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Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

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Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

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BATF regulates progenitor to cytolytic effector CD8+ T cell transition during chronic viral infection

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BMP4 and perivascular cells promote hematopoietic differentiation of human pluripotent stem cells in a differentiation stage-specific manner

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Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

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Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape

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TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

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SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment

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GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

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Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

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c-Jun overexpression in CAR T cells induces exhaustion resistance

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Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

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Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells

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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

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