SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment

The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

(2020) Eri Katsuyama et al.   Cell Reports

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

(2020) Jean-Christophe Beltra et al.   IMMUNITY

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

(2019) Sema Kurtulus et al.   IMMUNITY

Risk of immune-related adverse events associated with ipilimumab-plus-nivolumab and nivolumab therapy in cancer patients

(2019) Shi Zhou et al.   Therapeutics and Clinical Risk Management

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

Towards individualized therapy for metastatic renal cell carcinoma

(2019) Ritesh R. Kotecha et al.   Nature Reviews Clinical Oncology

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity and fate choice: T cell exhaustion in cancer and chronic infections

(2019) Mary Philip et al.   CURRENT OPINION IN IMMUNOLOGY

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

(2019) Francesca Alfei et al.   NATURE

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer

(2019) Burcu Yigit et al.   Cancer Immunology Research

Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups

(2019) Lawrence P. Andrews et al.   NATURE IMMUNOLOGY

SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond

(2019) O’Connell et al.   Vaccines

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

(2018) Jianfang Liu et al.   CELL

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

(2018) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells

(2018) Yukiyoshi Mita et al.   INTERNATIONAL IMMUNOLOGY

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

(2018) Moshe Sade-Feldman et al.   CELL

SLAMF7 Is a Critical Negative Regulator of IFN-α–Mediated CXCL10 Production in Chronic HIV Infection

(2018) Patrick O’Connell et al.   JOURNAL OF IMMUNOLOGY

Chromatin states define tumour-specific T cell dysfunction and reprogramming

(2017) Mary Philip et al.   NATURE

Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

(2017) Shan He et al.   Nature Communications

Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus

(2017) Denis Comte et al.   Arthritis & Rheumatology

Blimp-1/PRDM1 regulates the transcription of human CS1 (SLAMF7) gene in NK and B cells

(2016) Jong R. Kim et al.   IMMUNOBIOLOGY

Genetic and Epigenetic Regulation of PD-1 Expression

(2016) Alexander P. R. Bally et al.   JOURNAL OF IMMUNOLOGY

IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection

(2016) Jean-Christophe Beltra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer

(2015) N. A. Giraldo et al.   CLINICAL CANCER RESEARCH

FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data

(2015) Sofie Van Gassen et al.   CYTOMETRY PART A

Overcoming T cell exhaustion in infection and cancer

(2015) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

Immune Cell Inhibition by SLAMF7 Is Mediated by a Mechanism Requiring Src Kinases, CD45, and SHIP-1 That Is Defective in Multiple Myeloma Cells

(2014) Huaijian Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin

(2013) R. Remark et al.   CLINICAL CANCER RESEARCH

YY1 and a unique DNA repeat element regulates the transcription of mouse CS1 (CD319, SLAMF7) gene

(2013) Prachi Dongre et al.   MOLECULAR IMMUNOLOGY

Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma

(2013) Stefanie Regine Dannenmann et al.   OncoImmunology

TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

(2013) Kaori Sakuishi et al.   OncoImmunology

Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype

(2012) A. G. Chapuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses

(2012) Thomas Höfer et al.   Frontiers in Immunology

SLAM Family Receptors and SAP Adaptors in Immunity

(2011) Jennifer L. Cannons et al.   Annual Review of Immunology

Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection

(2011) T. Yamamoto et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

SPICE: Exploration and analysis of post-cytometric complex multivariate datasets

(2011) Mario Roederer et al.   CYTOMETRY PART A

Unknown

(2011) Esaki Shankar et al.   MOLECULAR MEDICINE

Expression of the SLAM Family of Receptors Adapter EAT-2 as a Novel Strategy for Enhancing Beneficial Immune Responses to Vaccine Antigens

(2010) Y. A. Aldhamen et al.   JOURNAL OF IMMUNOLOGY

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

(2009) Haina Shin et al.   IMMUNITY

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

(2009) Mario-Ernesto Cruz-Munoz et al.   NATURE IMMUNOLOGY