Genetic diversity fuels gene discovery for tobacco and alcohol use

The effects of tobacco control policies on global smoking prevalence

(2021) Luisa S. Flor et al.   NATURE MEDICINE

Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts

(2021) Travis T. Mallard et al.   AMERICAN JOURNAL OF PSYCHIATRY

The omnigenic model and polygenic prediction of complex traits

(2021) Iain Mathieson   AMERICAN JOURNAL OF HUMAN GENETICS

ECE 2 regulates neurogenesis and neuronal migration during human cortical development

(2020) Isabel Y Buchsbaum et al.   EMBO REPORTS

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease

(2020) Julien Bryois et al.   NATURE GENETICS

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

(2020) Hang Zhou et al.   NATURE NEUROSCIENCE

Genetic associations between voltage-gated calcium channels and autism spectrum disorder: a systematic review

(2020) Xiaoli Liao et al.   Molecular Brain

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

The Gene Ontology resource: enriching a GOld mine

(2020) et al.   NUCLEIC ACIDS RESEARCH

The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders

(2020) Kaifan Zhang et al.   Protein & Cell

Cauchy combination test: a powerful test with analytic p-value calculation under arbitrary dependency structures

(2019) Yaowu Liu et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Cohort Profile: The National Longitudinal Study of Adolescent to Adult Health (Add Health)

(2019) Kathleen Mullan Harris et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders

(2019) Arturo Andrade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking

(2019) William C. Buchta et al.   MOLECULAR NEUROBIOLOGY

PAKs in the brain: Function and dysfunction

(2018) Laura Civiero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mixed-model association for biobank-scale datasets

(2018) Po-Ru Loh et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes

(2018) Yu Jiang et al.   PLoS Genetics

Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Max G Griswold et al.   LANCET

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

(2018) Wei Zhou et al.   NATURE GENETICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

A rapid evidence review of the effectiveness and cost-effectiveness of alcohol control policies: an English perspective

(2017) Robyn Burton et al.   LANCET

Update of neurotrophic factors in neurobiology of addiction and future directions

(2017) Maryna Koskela et al.   NEUROBIOLOGY OF DISEASE

RVTESTS: an efficient and comprehensive tool for rare variant association analysis using sequence data: Table 1.

(2016) Xiaowei Zhan et al.   BIOINFORMATICS

A reference panel of 64,976 haplotypes for genotype imputation

(2016)   NATURE GENETICS

Neurobiologic Advances from the Brain Disease Model of Addiction

(2016) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

(2015) Robert Baranello et al.   Current Alzheimer Research

Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy

(2015) Andrii Domanskyi et al.   HUMAN GENE THERAPY

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

(2015) Laura Civiero et al.   JOURNAL OF NEUROCHEMISTRY

Molecular substrates of schizophrenia: homeostatic signaling to connectivity

(2015) M A Landek-Salgado et al.   MOLECULAR PSYCHIATRY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

MAGMA: Generalized Gene-Set Analysis of GWAS Data

(2015) Christiaan A. de Leeuw et al.   PLoS Computational Biology

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

A General Framework for Detecting Disease Associations with Rare Variants in Sequencing Studies

(2011) Dan-Yu Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

APCluster: an R package for affinity propagation clustering

(2011) U. Bodenhofer et al.   BIOINFORMATICS

Genomic inflation factors under polygenic inheritance

(2011) Jian Yang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A New Approach to Account for the Correlations among Single Nucleotide Polymorphisms in Genome-Wide Association Studies

(2011) Zhongxue Chen et al.   HUMAN HEREDITY

ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry

(2011) L J Bierut et al.   MOLECULAR PSYCHIATRY

The CHRNA5–A3–B4 gene cluster in nicotine addiction

(2011) W H Berrettini et al.   MOLECULAR PSYCHIATRY

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Neurocircuitry of Addiction

(2009) George F Koob et al.   NEUROPSYCHOPHARMACOLOGY

Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion

(2008) Tanya Nekrasova et al.   DEVELOPMENTAL BIOLOGY

p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis

(2008) Qiu-Lan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk

(2008) V Moskvina et al.   MOLECULAR PSYCHIATRY