The omnigenic model and polygenic prediction of complex traits

The evolution of group differences in changing environments

(2021) Arbel Harpak et al.   PLOS BIOLOGY

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background

(2021) Nasa Sinnott-Armstrong et al.   eLife

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals

(2021) Valentin Hivert et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Variable prediction accuracy of polygenic scores within an ancestry group

(2020) Hakhamanesh Mostafavi et al.   eLife

Evidence of Polygenic Adaptation in Sardinia at Height-Associated Loci Ascertained from the Biobank Japan

(2020) Minhui Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

(2020) Ying Wang et al.   Nature Communications

Demographic history mediates the effect of stratification on polygenic scores

(2020) Arslan A Zaidi et al.   eLife

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

(2019) Armin P. Schoech et al.   Nature Communications

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Modeling Heterogeneity in the Genetic Architecture of Ethnically Diverse Groups Using Random Effect Interaction Models

(2019) Yogasudha Veturi et al.   GENETICS

Trans Effects on Gene Expression Can Drive Omnigenic Inheritance

(2019) Xuanyao Liu et al.   CELL

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

(2019) Mashaal Sohail et al.   eLife

Reduced signal for polygenic adaptation of height in UK Biobank

(2019) Jeremy J Berg et al.   eLife

Genetic analyses of diverse populations improves discovery for complex traits

(2019) Genevieve L. Wojcik et al.   NATURE

Ultrarare variants drive substantial cis heritability of human gene expression

(2019) Ryan D. Hernandez et al.   NATURE GENETICS

Tread Lightly Interpreting Polygenic Tests of Selection

(2018) John Novembre et al.   GENETICS

Global genetic differentiation of complex traits shaped by natural selection in humans

(2018) Jing Guo et al.   Nature Communications

Tread Lightly Interpreting Polygenic Tests of Selection

(2018) John Novembre et al.   GENETICS

Estimating cross-population genetic correlations of causal effect sizes

(2018) Kevin J. Galinsky et al.   GENETIC EPIDEMIOLOGY

Multiethnic polygenic risk scores improve risk prediction in diverse populations

(2017) Carla Márquez-Luna et al.   GENETIC EPIDEMIOLOGY

Influence of Gene Interaction on Complex Trait Variation with Multilocus Models

(2014) Asko Mäki-Tanila et al.   GENETICS

A Population Genetic Signal of Polygenic Adaptation

(2014) Jeremy J. Berg et al.   PLoS Genetics

Evidence of widespread selection on standing variation in Europe at height-associated SNPs

(2012) Michael C Turchin et al.   NATURE GENETICS

Differential confounding of rare and common variants in spatially structured populations

(2012) Iain Mathieson et al.   NATURE GENETICS

Demographic history and rare allele sharing among human populations

(2011) S. Gravel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetics of Human Adaptation: Hard Sweeps, Soft Sweeps, and Polygenic Adaptation

(2010) Jonathan K. Pritchard et al.   CURRENT BIOLOGY

Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits

(2008) William G. Hill et al.   PLoS Genetics