The CHRNA5–A3–B4 gene cluster in nicotine addiction

Aversion to Nicotine Is Regulated by the Balanced Activity of β4 and α5 Nicotinic Receptor Subunits in the Medial Habenula

(2011) Silke Frahm et al.   NEURON

In Vitro and Ex Vivo Analysis of CHRNA3 and CHRNA5 Haplotype Expression

(2011) Glenn A. Doyle et al.   PLoS One

Aberrant DNA Methylation Links Cancer Susceptibility Locus 15q25.1 to Apoptotic Regulation and Lung Cancer

(2010) Anupam Paliwal et al.   CANCER RESEARCH

Nicotinic α5 receptor subunit mRNA expression is associated with distant 5′ upstream polymorphisms

(2010) Ryan M Smith et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Commentary: Gene-environment interactions and smoking-related cancers

(2010) T. E. Thorgeirsson et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Promoter Polymorphisms and Transcript Levels of Nicotinic Receptor CHRNA5

(2010) Felicia S. Falvella et al.   JNCI-Journal of the National Cancer Institute

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(2010) George Uhl et al.   MOLECULAR MEDICINE

Acetylcholine Receptor (AChR)  5 Subunit Variant Associated with Risk for Nicotine Dependence and Lung Cancer Reduces ( 4 2)2 5 AChR Function

(2010) A. Kuryatov et al.   MOLECULAR PHARMACOLOGY

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

(2010) Jason Z Liu et al.   NATURE GENETICS

Partial Agonists of the α3β4* Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats

(2010) Susmita Chatterjee et al.   NEUROPSYCHOPHARMACOLOGY

Associations of Variants in CHRNA5/A3/B4 Gene Cluster with Smoking Behaviors in a Korean Population

(2010) Ming D. Li et al.   PLoS One

Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

(2010) Magda Granata et al.   PLoS Genetics

Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers

(2009) Sherry A. McKee et al.   BIOLOGICAL PSYCHIATRY

Genetic Variants on Chromosome 15q25 Associated with Lung Cancer Risk in Chinese Populations

(2009) C. Wu et al.   CANCER RESEARCH

The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans

(2009) N. L. Saccone et al.   CANCER RESEARCH

Transcription Deregulation at the 15q25 Locus in Association with Lung Adenocarcinoma Risk

(2009) F. S. Falvella et al.   CLINICAL CANCER RESEARCH

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy

(2009) Rachel M. Freathy et al.   HUMAN MOLECULAR GENETICS

Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15

(2009) Kaisu Keskitalo et al.   HUMAN MOLECULAR GENETICS

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

(2009) Jen C. Wang et al.   HUMAN MOLECULAR GENETICS

Nicotine Dependence Pharmacogenetics: Role of Genetic Variation in Nicotine-Metabolizing Enzymes

(2009) Riju Ray et al.   JOURNAL OF NEUROGENETICS

Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors

(2009) Neil Caporaso et al.   PLoS One

A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia

(2009) Anna C. Need et al.   PLoS Genetics

Variants in Nicotinic Receptors and Risk for Nicotine Dependence

(2008) Laura Jean Bierut et al.   AMERICAN JOURNAL OF PSYCHIATRY

Molecular Genetics of Successful Smoking Cessation

(2008) George R. Uhl et al.   ARCHIVES OF GENERAL PSYCHIATRY

The CHRNA5/A3/B4 Gene Cluster Variability as an Important Determinant of Early Alcohol and Tobacco Initiation in Young Adults

(2008) Isabel R. Schlaepfer et al.   BIOLOGICAL PSYCHIATRY

Smoking Cessation and Variations in Nicotinic Acetylcholine Receptor Subunits α-5, α-3, and β-4 Genes

(2008) Lutz Philipp Breitling et al.   BIOLOGICAL PSYCHIATRY

Smokers with the CHRNA Lung Cancer-Associated Variants Are Exposed to Higher Levels of Nicotine Equivalents and a Carcinogenic Tobacco-Specific Nitrosamine

(2008) L. Le Marchand et al.   CANCER RESEARCH

Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese

(2008) Kouya Shiraishi et al.   CARCINOGENESIS

Nicotinic acetylcholine receptor β2 subunit gene implicated in a systems-based candidate gene study of smoking cessation

(2008) David V. Conti et al.   HUMAN MOLECULAR GENETICS

Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer

(2008) Pengyuan Liu et al.   JNCI-Journal of the National Cancer Institute

The CHRNA5-A3 Region on Chromosome 15q24-25.1 Is a Risk Factor Both for Nicotine Dependence and for Lung Cancer

(2008) Margaret R. Spitz et al.   JNCI-Journal of the National Cancer Institute

One SNP linked to two diseases—addiction and cancer: A Double Whammy?: Nicotine addiction and lung cancer susceptibility

(2008) N Volkow et al.   MOLECULAR PSYCHIATRY

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

(2008) J C Wang et al.   MOLECULAR PSYCHIATRY

α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking

(2008) W Berrettini et al.   MOLECULAR PSYCHIATRY

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

(2008) Thorgeir E. Thorgeirsson et al.   NATURE

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

(2008) Rayjean J. Hung et al.   NATURE

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

(2008) Christopher I Amos et al.   NATURE GENETICS

Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans

(2008) G. Joslyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction

(2008) Robert B. Weiss et al.   PLoS Genetics