APOE effects on regional tau in preclinical Alzheimer’s disease

Blood and brain transcriptome analysis reveals APOE genotype-mediated and immune-related pathways involved in Alzheimer disease

(2022) Rebecca Panitch et al.   Alzheimers Research & Therapy

Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease

(2022) Christina B. Young et al.   JAMA Neurology

Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia

(2022) Diego Sepulveda-Falla et al.   ACTA NEUROPATHOLOGICA

APOE targeting strategy in Alzheimer’s disease: lessons learned from protective variants

(2022) Guojun Bu   Molecular Neurodegeneration

Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment

(2022) Cherie Strikwerda-Brown et al.   JAMA Neurology

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

(2022) Rosalía Fernández-Calle et al.   Molecular Neurodegeneration

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia

(2021) Gemma Salvadó et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach

(2021) Sarah K. Royse et al.   Alzheimers Research & Therapy

Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms

(2021) Nicole Koutsodendris et al.   Annual Review of Pathology-Mechanisms of Disease

Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET

(2021) Suzanne Schindler et al.   NEUROLOGY

Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease

(2021) Rik Ossenkoppele et al.   JAMA Neurology

Amyloid time: Quantifying the onset of abnormal biomarkers and cognitive impairment along the Alzheimer’s disease continuum

(2021) Tobey J. Betthauser et al.   Alzheimers & Dementia

The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

(2021) Giovanni B. Frisoni et al.   NATURE REVIEWS NEUROSCIENCE

Abnormal tau in amyloid PET negative individuals

(2021) Bora Yoon et al.   NEUROBIOLOGY OF AGING

Influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [18F]-AV-1451 PET data

(2021) Christina B. Young et al.   NEUROIMAGE

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

(2020) Eric M. Reiman et al.   Nature Communications

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Influence of apolipoprotein-E genotype on brain amyloid load and longitudinal trajectories

(2020) Brian J. .Lopresti et al.   NEUROBIOLOGY OF AGING

Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals

(2020) Reisa A. Sperling et al.   JAMA Neurology

Dynamic spatiotemporal beams that combine two independent and controllable orbital-angular-momenta using multiple optical-frequency-comb lines

(2020) Zhe Zhao et al.   Nature Communications

Association Between Apolipoprotein E ε2 vs ε4, Age, and β-Amyloid in Adults Without Cognitive Impairment

(2020) Philip S. Insel et al.   JAMA Neurology

The impact of demographic, clinical, genetic, and imaging variables on tau PET status

(2020) Rik Ossenkoppele et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Association of APOE4 and clinical variability in Alzheimer disease with the pattern of tau- and amyloid-PET

(2020) Renaud La Joie et al.   NEUROLOGY

Time between milestone events in the Alzheimer's disease amyloid cascade

(2020) Philip S. Insel et al.   NEUROIMAGE

Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults

(2019) Rachel F. Buckley et al.   JAMA Neurology

APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points

(2019) Jon B. Toledo et al.   JOURNAL OF ALZHEIMERS DISEASE

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

(2019) Val J. Lowe et al.   NEUROLOGY

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes

(2019) Clifford R Jack et al.   BRAIN

ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles

(2019) Bruna dos Santos Rodrigues et al.   PHARMACEUTICAL RESEARCH

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

(2019) Tien-Phat V. Huynh et al.   Molecular Neurodegeneration

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Brain imaging measurements of fibrillar amyloid‐β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele

(2019) Valentina Ghisays et al.   Alzheimers & Dementia

Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age

(2019) Tobey J Betthauser et al.   BRAIN

Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology

(2019) Joost M. Riphagen et al.   NEUROBIOLOGY OF AGING

Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β

(2019) Joseph Therriault et al.   JAMA Neurology

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

(2018) Niklas Mattsson et al.   Alzheimers & Dementia

Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype

(2018) Shruti Mishra et al.   BRAIN

The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

(2018) Sven J van der Lee et al.   LANCET NEUROLOGY

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

(2018) Chengzhong Wang et al.   NATURE MEDICINE

Dissociable influences ofAPOEε4 and polygenic risk of AD dementia on amyloid and cognition

(2018) Tian Ge et al.   NEUROLOGY

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study

(2018) Niklas Mattsson et al.   Alzheimers Research & Therapy

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease

(2017) Anne Maass et al.   NEUROIMAGE

APOE genotype and early β-amyloid accumulation in older adults without dementia

(2017) Yen Ying Lim et al.   NEUROLOGY

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2016) Yu Yamazaki et al.   CNS DRUGS

Association of APOE with tau-tangle pathology with and without β-amyloid

(2016) Jose M. Farfel et al.   NEUROBIOLOGY OF AGING

Assessment of the genetic variance of late-onset Alzheimer's disease

(2016) Perry G. Ridge et al.   NEUROBIOLOGY OF AGING

The Distribution of Apolipoprotein E Genotype Over The Adult Lifespan and in Relation to Country of Birth

(2015) Silke Kern et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

APOEε2 is associated with milder clinical and pathological Alzheimer disease

(2015) Alberto Serrano-Pozo et al.   ANNALS OF NEUROLOGY

Prevalence of Amyloid PET Positivity in Dementia Syndromes

(2015) Rik Ossenkoppele et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

APOE and cerebral amyloid angiopathy in community-dwelling older persons

(2015) Lei Yu et al.   NEUROBIOLOGY OF AGING

Dangerous Leaks: Blood-Brain Barrier Woes in the Aging Hippocampus

(2015) Costantino Iadecola   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased withAPOE4and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

(2013) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The APOE ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients

(2013) Karin Hultman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature

(2013) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles

(2009) D. A. Bennett et al.   NEUROLOGY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON