Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

(2020) Eric M. Reiman et al.   Nature Communications

Characterization of Alzheimer Disease Biomarker Discrepancies Using Cerebrospinal Fluid Phosphorylated Tau and AV1451 Positron Emission Tomography

(2020) Pierre-François Meyer et al.   JAMA Neurology

Regional [18F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer’s disease

(2020) Emma E. Wolters et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease

(2020) Niklas Mattsson-Carlgren et al.   Science Advances

Sex differences in CSF biomarkers vary by Alzheimer’s disease stage and APOE ε4 genotype

(2020) Rosha Babapour Mofrad et al.   NEUROLOGY

Sex differences in Alzheimer’s-related Tau biomarkers and a mediating effect of testosterone

(2020) Erin E. Sundermann et al.   Biology of Sex Differences

Predicting future rates of tau accumulation on PET

(2020) Clifford R. Jack   Alzheimers & Dementia

The biomarker roadmap for the validation for Alzheimer’s biomarkers: Methodological update for biomarkers of tauopathy

(2020) Marina Boccardi et al.   Alzheimers & Dementia

Longitudinal tau accumulation and atrophy in aging and alzheimer disease

(2019) Theresa M. Harrison et al.   ANNALS OF NEUROLOGY

Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer’s disease

(2019) Antoine Leuzy et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Alcohol use and dementia: a systematic scoping review

(2019) Jürgen Rehm et al.   Alzheimers Research & Therapy

A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward

(2019) Michaël E. Belloy et al.   NEURON

Associations between baseline amyloid, sex and APOE on subsequent tau accumulation in cerebrospinal fluid

(2019) Rachel F. Buckley et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

(2019) Rik van der Kant et al.   NATURE REVIEWS NEUROSCIENCE

Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β

(2019) Joseph Therriault et al.   JAMA Neurology

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review

(2018) M. Clare O'Donoghue et al.   CORTEX

APOEε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults

(2018) Shahram Oveisgharan et al.   NEUROLOGY

Resistance vs resilience to Alzheimer disease

(2018) Eider M. Arenaza-Urquijo et al.   NEUROLOGY

Diffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-β-induced pathology

(2018) Jelle Praet et al.   Alzheimers Research & Therapy

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

(2018) Timothy J. Hohman et al.   JAMA Neurology

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus

(2018) Emma E. Wolters et al.   EJNMMI Research

Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease

(2018) Jacob W. Vogel et al.   HUMAN BRAIN MAPPING

Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease

(2018) Colin Groot et al.   NEUROLOGY

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

(2017) Giovanni B Frisoni et al.   LANCET NEUROLOGY

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease

(2017) Anne Maass et al.   NEUROIMAGE

Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load

(2017) Michel J. Grothe et al.   NEUROLOGY

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

The relationship between cerebrospinal fluid markers of Alzheimer pathology and positron emission tomography tau imaging

(2016) Brian A. Gordon et al.   BRAIN

Association of APOE with tau-tangle pathology with and without β-amyloid

(2016) Jose M. Farfel et al.   NEUROBIOLOGY OF AGING

Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly

(2016) Jasmeer P. Chhatwal et al.   NEUROLOGY

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

(2015) William E. Klunk et al.   Alzheimers & Dementia

APOEε2 is associated with milder clinical and pathological Alzheimer disease

(2015) Alberto Serrano-Pozo et al.   ANNALS OF NEUROLOGY

Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects

(2015) Jon B. Toledo et al.   BRAIN

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls

(2015) Frederic Sampedro et al.   Oncotarget

Age, Sex, andAPOEε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span

(2015) Clifford R. Jack et al.   JAMA Neurology

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

When to use the Bonferroni correction

(2014) Richard A. Armstrong   OPHTHALMIC AND PHYSIOLOGICAL OPTICS

The influence of Apolipoprotein E genotype on regional pathology in Alzheimer’s disease

(2013) Marwan N Sabbagh et al.   BMC Neurology

Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients

(2013) M. Lehmann et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

A 2-process model for neuropathology of Alzheimer's disease

(2013) Dan Mungas et al.   NEUROBIOLOGY OF AGING

Disentangling the effects of age and APOE on neuropathology and late life cognitive decline

(2013) Lei Yu et al.   NEUROBIOLOGY OF AGING

The forgotten APOE allele: A review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2

(2013) Sana Suri et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Development and assessment of a composite score for memory in the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

(2012) Paul K. Crane et al.   Brain Imaging and Behavior

A composite score for executive functioning, validated in Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment

(2012) Laura E. Gibbons et al.   Brain Imaging and Behavior

Origins of Alzheimerʼs disease

(2012) Erik S. Musiek et al.   CURRENT OPINION IN NEUROLOGY

Gender Modulates the APOE  4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels

(2012) J. S. Damoiseaux et al.   JOURNAL OF NEUROSCIENCE

Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia

(2012) R. Ossenkoppele et al.   NEUROLOGY

Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects

(2010) G. C. Chiang et al.   NEUROLOGY

Association between APOE genotype, neuropathology and dementia in the older population of England and Wales

(2010) J. A. R. Nicoll et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

Neuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles

(2009) D. A. Bennett et al.   NEUROLOGY

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA