Macroalgae Specialized Metabolites: Evidence for Their Anti-Inflammatory Health Benefits

GC- and UHPLC-MS Profiles as a Tool to Valorize the Red Alga Asparagopsis armata

(2022) Diana C. G. A. Pinto et al.   Applied Sciences-Basel

Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review

(2022) Hossam S. El-Beltagi et al.   Marine Drugs

Fucosterol Isolated from Dietary Brown Alga Sargassum horneri Protects TNF-α/IFN-γ-Stimulated Human Dermal Fibroblasts Via Regulating Nrf2/HO-1 and NF-κB/MAPK Pathways

(2022) Kirinde Gedara Isuru Sandanuwan Kirindage et al.   Antioxidants

Algae as Food in Europe: An Overview of Species Diversity and Their Application

(2022) Madalena Mendes et al.   Foods

Primary Composition and Pigments of 11 Red Seaweed Species from the Center of Portugal

(2022) Marta V. Freitas et al.   Journal of Marine Science and Engineering

ROS-responsive PPGF nanofiber membrane as a drug delivery system for long-term drug release in attenuation of osteoarthritis

(2022) Jianjun Wu et al.   npj Regenerative Medicine

Phytochemical and anti-inflammatory properties of green macroalga Codium tomentosum

(2022) R. Rabecca et al.   Biocatalysis and Agricultural Biotechnology

Current Status of the Algae Production Industry in Europe: An Emerging Sector of the Blue Bioeconomy

(2021) Rita Araújo et al.   Frontiers in Marine Science

Sargassum horneri (Turner) C. Agardh ethanol extract attenuates fine dust-induced inflammatory responses and impaired skin barrier functions in HaCaT keratinocytes

(2021) Mawalle Kankanamge Hasitha Madhawa Dias et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antitumor Activity of Fucus vesiculosus-Derived Phlorotannins through Activation of Apoptotic Signals in Gastric and Colorectal Tumor Cell Lines

(2021) Marcelo D. Catarino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Temporal and spatial variation of seaweed biomass and assemblages in Northwest Portugal

(2021) Rosa Melo et al.   JOURNAL OF SEA RESEARCH

Differential and shared effects of eicosapentaenoic acid and docosahexaenoic acid on serum metabolome in subjects with chronic inflammation

(2021) Wan-Chi Chang et al.   Scientific Reports

Fucosterol of Marine Macroalgae: Bioactivity, Safety and Toxicity on Organism

(2021) Maria Dyah Nur Meinita et al.   Marine Drugs

Emerging algal nanotechnology for high-value compounds: A direction to future food production

(2021) Apurav Krishna Koyande et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Phlorotannins: A review of extraction methods, structural characteristics, bioactivities, bioavailability, and future trends

(2021) Weihao Meng et al.   Algal Research-Biomass Biofuels and Bioproducts

Omega−3 Polyunsaturated Fatty Acids (PUFAs): Emerging Plant and Microbial Sources, Oxidative Stability, Bioavailability, and Health Benefits—A Review

(2021) Ramesh Kumar Saini et al.   Antioxidants

Health benefits of fucoxanthin in the prevention of chronic diseases

(2020) Minkyung Bae et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders

(2020) Juliette Giacobbe et al.   Frontiers in Psychiatry

Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation

(2020) Youzhe Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimisation of Ultrasound Frequency, Extraction Time and Solvent for the Recovery of Polyphenols, Phlorotannins and Associated Antioxidant Activity from Brown Seaweeds

(2020) Viruja Ummat et al.   Marine Drugs

Phytosterols of marine algae: Insights into the potential health benefits and molecular pharmacology

(2020) Md. Abdul Hannan et al.   PHYTOMEDICINE

Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin

(2020) Kazuo Miyashita et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Fucoxanthin: A promising compound for human inflammation-related diseases

(2020) Mingjun Liu et al.   LIFE SCIENCES

Seaweeds as a Functional Ingredient for a Healthy Diet

(2020) Rocío Peñalver et al.   Marine Drugs

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

(2020) Minghua Jiang et al.   Marine Drugs

Highlighting the Biological Potential of the Brown Seaweed Fucus spiralis for Skin Applications

(2020) Rafaela Freitas et al.   Antioxidants

Beyond the joints, the extra-articular manifestations in rheumatoid arthritis

(2020) Alessandro Conforti et al.   AUTOIMMUNITY REVIEWS

First report of antioxidative 2H-chromenyl derivatives from the intertidal red seaweed Gracilaria salicornia as potential anti-inflammatory agents

(2019) Tima Antony et al.   NATURAL PRODUCT RESEARCH

Fucoxanthin Protects Against oxLDL‐Induced Endothelial Damage via Activating the AMPK‐Akt‐CREB‐PGC1α Pathway

(2019) Hsiu‐Chung Ou et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Neorogioltriol and Related Diterpenes from the Red Alga Laurencia Inhibit Inflammatory Bowel Disease in Mice by Suppressing M1 and Promoting M2-Like Macrophage Responses

(2019) Maria Daskalaki et al.   Marine Drugs

Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi (Sonder ex J. Agardh)

(2019) I.P. Shanura Fernando et al.   ENVIRONMENTAL RESEARCH

Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases

(2019) Maria Cristina Barbalace et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The seaweed resources of Portugal

(2019) Rui Gaspar et al.   BOTANICA MARINA

Enzyme-assisted extraction of bioactive compounds from brown seaweeds and characterization

(2019) Sabeena Farvin K. Habeebullah et al.   JOURNAL OF APPLIED PHYCOLOGY

The Protective Effect of Mycosporine-Like Amino Acids (MAAs) from Porphyra yezoensis in a Mouse Model of UV Irradiation-Induced Photoaging

(2019) Rui Ying et al.   Marine Drugs

Fucoxanthin, a Marine Xanthophyll Isolated From Conticribra weissflogii ND-8: Preventive Anti-Inflammatory Effect in a Mouse Model of Sepsis

(2019) Jingqian Su et al.   Frontiers in Pharmacology

Bioactive compounds in seaweeds: An overview of their biological properties and safety

(2019) Kannan RR. Rengasamy et al.   FOOD AND CHEMICAL TOXICOLOGY

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

(2019) Gonçalo P. Rosa et al.   Marine Drugs

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Bis (3-bromo-4,5-dihydroxybenzyl) ether, a novel bromophenol from the marine red alga Polysiphonia morrowii that suppresses LPS-induced inflammatory response by inhibiting ROS-mediated ERK signaling pathway in RAW 264.7 macrophages

(2018) Youn Kyung Choi et al.   BIOMEDICINE & PHARMACOTHERAPY

Algae in food- a general review

(2018) Sylwia Ścieszka et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Microwave assisted extraction of phenolic compounds from four economic brown macroalgae species and evaluation of their antioxidant activities and inhibitory effects on α-amylase, α-glucosidase, pancreatic lipase and tyrosinase

(2018) Yuan Yuan et al.   FOOD RESEARCH INTERNATIONAL

Fucosterol inhibits the cholinesterase activities and reduces the release of pro-inflammatory mediators in lipopolysaccharide and amyloid-induced microglial cells

(2018) Chun Hoong Wong et al.   JOURNAL OF APPLIED PHYCOLOGY

Novel furanyl derivatives from the red seaweed Gracilaria opuntia with pharmacological activities using different in vitro models

(2018) Fasina Makkar et al.   MEDICINAL CHEMISTRY RESEARCH

Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity

(2018) Wenhui Mo et al.   Gastroenterology Research and Practice

The Bisindole Alkaloid Caulerpin, from Seaweeds of the Genus Caulerpa, Attenuated Colon Damage in Murine Colitis Model

(2018) Alessandra Lucena et al.   Marine Drugs

Orally Administered Phlorotannins from Eisenia arborea Suppress Chemical Mediator Release and Cyclooxygenase-2 Signaling to Alleviate Mouse Ear Swelling

(2018) Yoshimasa Sugiura et al.   Marine Drugs

Phlorotannins are Polyphenolic Metabolites of Brown Algae

(2018) T. I. Imbs et al.   Russian Journal of Marine Biology

Protective role of fucoxanthin in diethylnitrosamine-induced hepatocarcinogenesis in experimental adult rats

(2018) Xin Jin et al.   DRUG DEVELOPMENT RESEARCH

Fucoxanthin-Containing Cream Prevents Epidermal Hyperplasia and UVB-Induced Skin Erythema in Mice

(2018) Azahara Rodríguez-Luna et al.   Marine Drugs

First report of antioxidant abeo-labdane type diterpenoid from intertidal red seaweed Gracilaria salicornia with 5-lipoxygenase inhibitory potential

(2018) Tima Antony† et al.   NATURAL PRODUCT RESEARCH

3‑Bromo‑5‑(ethoxymethyl)‑1,2‑benzenediol inhibits LPS-induced pro-inflammatory responses by preventing ROS production and downregulating NF-κB in vitro and in a zebrafish model

(2018) Eun-Yi Ko et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Marine Natural Product Bis-indole Alkaloid Caulerpin: Chemistry and Biology

(2017) Jignesh Lunagariya et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Highly oxygenated antioxidative 2H-chromen derivative from the red seaweed Gracilaria opuntia with pro-inflammatory cyclooxygenase and lipoxygenase inhibitory properties

(2017) Fasina Makkar et al.   NATURAL PRODUCT RESEARCH

Facile production of seaweed-based biomaterials with antioxidant and anti-inflammatory activities

(2017) Susana Guzman-Puyol et al.   Algal Research-Biomass Biofuels and Bioproducts

Potential anti-inflammatory natural products from marine algae

(2016) I.P. Shanura Fernando et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Eckol fromEisenia bicyclisInhibits Inflammation Through the Akt/NF-κB Signaling inPropionibacterium acnes-Induced Human Keratinocyte Hacat Cells

(2016) Sung-Hwan Eom et al.   JOURNAL OF FOOD BIOCHEMISTRY

Health benefit of fucosterol from marine algae: a review

(2016) Qudeer Ahmed Abdul et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase in Vitro

(2016) Jiajia Lin et al.   Marine Drugs

Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-κB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells

(2016) Dong Zhao et al.   NEUROCHEMICAL RESEARCH

Fucofuroeckol-A fromEisenia bicyclisInhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway

(2016) Sang-Hoon Lee et al.   Journal of Chemistry

Phlorofucofuroeckol B suppresses inflammatory responses by down-regulating nuclear factor κB activation via Akt, ERK, and JNK in LPS-stimulated microglial cells

(2015) Dong-Kyung Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fucosterol protects cobalt chloride induced inflammation by the inhibition of hypoxia-inducible factor through PI3K/Akt pathway

(2015) Zhengwang Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of galactofucan sulfate of a brown seaweed on induced hepatotoxicity in rats, sodium pentobarbital-induced sleep, and anti-inflammatory activity

(2015) Luiza Sheyla Evenni P. Will Castro et al.   JOURNAL OF APPLIED PHYCOLOGY

Fucosterol attenuates lipopolysaccharide-induced acute lung injury in mice

(2015) Yuexia Li et al.   JOURNAL OF SURGICAL RESEARCH

Alternative and Efficient Extraction Methods for Marine-Derived Compounds

(2015) Clara Grosso et al.   Marine Drugs

Fucoxanthinol, Metabolite of Fucoxanthin, Improves Obesity-Induced Inflammation in Adipocyte Cells

(2015) Hayato Maeda et al.   Marine Drugs

NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

(2015) Ruey-Horng Shih et al.   Frontiers in Molecular Neuroscience

5β-Hydroxypalisadin B isolated from red alga Laurencia snackeyi attenuates inflammatory response in lipopolysaccharide-stimulated RAW 264.7 macrophages

(2015) W.A.J.P. Wijesinghe et al.   ALGAE

Algal extracts: Technology and advances

(2014) Izabela Michalak et al.   ENGINEERING IN LIFE SCIENCES

Fucoxanthin Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes

(2014) Jian Zheng et al.   Marine Drugs

PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF κB activity

(2013) Zhan Chengye et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Octaphlorethol A Inhibits the CpG-Induced Inflammatory Response by Attenuating the Mitogen-Activated Protein Kinase and NF-κB Pathways

(2013) Zahid MANZOOR et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Assessment of anti-inflammatory effect of 5β-hydroxypalisadin B isolated from red seaweed Laurencia snackeyi in zebrafish embryo in vivo model

(2013) W.A.J.P. Wijesinghe et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages

(2013) Hyun Ah Jung et al.   FOOD AND CHEMICAL TOXICOLOGY

TNF-α signalling and inflammation: interactions between old acquaintances

(2013) Hana Zelová et al.   INFLAMMATION RESEARCH

Application of Novel Extraction Technologies for Bioactives from Marine Algae

(2013) Shekhar U. Kadam et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Red Seaweed Gracilaria gracilis as a Multi Products Source

(2013) Matteo Francavilla et al.   Marine Drugs

Fucosterol Inhibits Matrix Metalloproteinase Expression and Promotes Type-1 Procollagen Production in UVB-induced HaCaT Cells

(2013) Myung-Suk Kim et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Vascular barrier protective effects of eckol and its derivatives

(2012) Tae Hoon Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Vascular barrier protective effects of phlorotannins on HMGB1-mediated proinflammatory responses in vitro and in vivo

(2012) Tae Hoon Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage

(2012) Soo-Jin Heo et al.   FOOD AND CHEMICAL TOXICOLOGY

6,6′-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE2 production and inflammatory cytokine expression in macrophages: The inhibition of NFκB

(2012) Yeong-In Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

In Vitro antiviral activity of red alga, Polysiphonia morrowii extract and its bromophenols against fish pathogenic infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus

(2011) Su-Yeun Kim et al.   JOURNAL OF MICROBIOLOGY

Polyunsaturated fatty acids in various macroalgal species from north Atlantic and tropical seas

(2011) Vincent JT van Ginneken et al.   Lipids in Health and Disease

Bromophenols in Marine Algae and Their Bioactivities

(2011) Ming Liu et al.   Marine Drugs

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

Effect of phloroglucinol on oxidative stress and inflammation

(2010) Moon-Moo Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata

(2010) Katarzyna Kazłowska et al.   JOURNAL OF ETHNOPHARMACOLOGY

Alkaloids in Marine Algae

(2010) Kasım Cemal Güven et al.   Marine Drugs

Two enone fatty acids isolated from Gracilaria verrucosa suppress the production of inflammatory mediators by down-regulating NF-κB and STAT1 activity in lipopolysaccharide-stimulated RAW 264.7 cells

(2009) Hye-Ja Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale

(2009) Philip C. Calder   BIOCHIMIE

Inhibitory Effects and Molecular Mechanism of Dieckol Isolated from Marine Brown Alga on COX-2 and iNOS in Microglial Cells

(2009) Won-Kyo Jung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds

(2009) Aránzazu Bocanegra et al.   JOURNAL OF MEDICINAL FOOD

The Antinociceptive and Anti-Inflammatory Activities of Caulerpin, a Bisindole Alkaloid Isolated from Seaweeds of the Genus Caulerpa

(2009) Éverton Tenório De Souza et al.   Marine Drugs

Trends in the non-steroidal anti-inflammatory drug market in six Central-Eastern European countries based on retail information

(2009) András Inotai et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Neorogioltriol: A brominated diterpene with analgesic activity from Laurencia glandulifera

(2008) Rim Chatter et al.   Phytochemistry Letters