Article
Oncology
Birandra K. Sinha, Erik J. Tokar, Jianying Li, Pierre R. Bushel
Summary: The nitric oxide donor NCX4040 exhibits cytotoxicity towards ovarian tumor cells by generating reactive oxygen species and inducing DNA damage. It also depletes cellular glutathione and induces oxidative stress, resulting in tumor cell death. NCX4040 treatment leads to the induction of oxidative stress genes, inflammatory response genes, DNA damage response genes, and MAP kinase response genes.
Article
Environmental Sciences
Heba O. Mohammed, Eman Ahmed Alaa El-Din, Azza I. Farag
Summary: The study found that the use of electronic cigarettes resulted in marked pathological alterations in the colonic mucosa, which could be attributed to oxidative and inflammatory stresses. However, cessation of exposure led to recovery in the colonic mucosal histological structure, downregulation of inflammatory markers, and restoration of oxidant/antioxidant balance.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alejandro Cenalmor, Elena Pascual, Sergio Gil-Manso, Rafael Correa-Rocha, Jose Ramon Suarez, Isabel Garcia-Alvarez
Summary: Neuroinflammation is a critical factor in the progression of Alzheimer's disease and other neurodegenerative disorders. In this study, a series of isatin derivatives were synthesized and evaluated for their anti-neuroinflammatory potential using lipopolysaccharide activated microglia as a cell model. Compound 10 with N-1 alkylation and compound 20 with chlorination showed the best results in reducing nitric oxide, pro-inflammatory interleukin 6, and tumour necrosis factor alpha release by microglial cells, indicating their potential as lead compounds for developing new neuroprotective agents.
Article
Biochemistry & Molecular Biology
Amelia Barilli, Giulia Recchia Luciani, Rossana Visigalli, Roberto Sala, Maurizio Soli, Valeria Dall'Asta, Bianca Maria Rotoli
Summary: This study explores the mechanisms underlying the modulation of iNOS expression in human alveolar cells. The researchers found that cytokines secreted by SARS-CoV-2 spike S1-activated macrophages markedly induce iNOS expression, which can be suppressed by the drug baricitinib. These findings are important for understanding the inflammatory response mechanisms in COVID-19 and identifying potential therapeutic drugs.
Article
Pharmacology & Pharmacy
Romaissaa Mokdad, Cendrine Seguin, Sylvie Fournel, Benoit Frisch, Beatrice Heurtault, Abdelkader Hadjsadok
Summary: The aim of this study was to formulate liposomes encapsulating highly mineralized thermal waters and investigate their anti-inflammatory effect on stimulated macrophage cells. The results showed that the liposomes loaded with thermal waters had good physical stability and demonstrated anti-inflammatory effects, making them suitable for treating inflammatory skin diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Ildernandes Vieira-Alves, Antonielle Rodrigues Pereira Alves, Natalia Muradas Valerio Souza, Tales Leonardo de Melo, Leda Maria de Castro Coimbra Campos, Larisse de Souza Barbosa Lacerda, Celso Martins Queiroz-Junior, Ana Claudia dos Santos Pereira Andrade, Luciola Silva Barcelos, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Steyner F. Cortes, Virginia S. Lemos
Summary: Poor disease outcomes and lethality in beta-coronavirus infections are directly related to endothelial dysfunction. This study investigated the mechanisms underlying vascular dysfunction caused by the betacoronaviruses MHV-3 and SARS-CoV-2. The results showed that MHV-3 infection reduced contractility, blood pressure, and blood flow, leading to death. Similar vascular dysfunction was observed in SARS-CoV-2 infection. These findings highlight the important role of the vascular endothelium and TNF in the pathogenesis and lethality of coronaviruses.
Article
Chemistry, Medicinal
Mohamed A. A. Tammam, Maria G. G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. C. Kampranis, Christos Tsatsanis, Vassilios Roussis, Efstathia Ioannou
Summary: The chemical investigation of the organic extract of the red alga Laurencia majuscula resulted in the isolation of several new natural products with significant anti-inflammatory activity. The structures and configurations of these natural products were determined through NMR, MS, and single-crystal X-ray diffraction analysis. The most prominent anti-inflammatory activity was exhibited by compounds 5 and 18.
Article
Biochemistry & Molecular Biology
Achara Raksat, Siwattra Choodej, Thammarat Aree, Samad Nejad Ebrahimi, Khanitha Pudhom
Summary: Eight new cassane diterpenes, pterolobirins C-J, along with two known analogs, were isolated from the roots of Pterolobium macropterum. The structure of pterolobirin J was confirmed by X-ray diffraction analysis. Pterolobirin E and sucutinirane C exhibited significant inhibition of nitric oxide production.
Article
Immunology
Manivel Rengasamy, Anna Marsland, Lora McClain, Tessa Kovats, Thomas Walko, Lisa Pan, Rebecca B. Price
Summary: The study found that in adolescents receiving standard-of-care community treatment, TNF alpha levels were positively correlated with depression severity and anhedonia symptoms, with higher baseline TNF alpha levels predicting more severe depression symptoms in the future. However, no association was found between changes in clinical measures and changes in cytokine levels over time.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Oncology
Paige C. Arneson-Wissink, Jason D. Doles
Summary: Skeletal muscle wasting is a key driver of negative clinical outcomes and is associated with a range of pathologies including cancer. Cancer cachexia is a multi-factorial syndrome that includes skeletal muscle wasting, but remains understudied. Research suggests that amino acid metabolic disruption is linked to myoblast defects induced by cancer cell conditioned media.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Esperanza Herradon, Cristina Gonzalez, Antonio Gonzalez, Jose Antonio Uranga, Visitacion Lopez-Miranda
Summary: Chronic treatment with vincristine causes alterations in vascular function, including endothelial dysfunction in the aorta and decreased contractile function in mesenteric arteries, but these changes disappear after treatment cessation. Vincristine treatment leads to significant changes in the expression of proteins like eNOS, TNF alpha, and connexin 43 in cardiovascular tissues, indicating direct toxicity during treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Fisheries
Mingmin Lu, Youngsub Lee, Charles Li, Hyun S. Lillehoj
Summary: In this study, chTNF-alpha was functionally characterized and its immunomodulatory properties were explored using novel anti-chTNF-alpha mouse monoclonal antibodies. The tissue expression of chTNF-alpha was determined, and a specific antigen-capture sandwich ELISA was developed to measure its levels. The intracellular expression of chTNF-alpha in chicken immune cells was validated, and the antibodies were found to neutralize chTNF-alpha-induced nitric oxide production. These findings enhance our understanding of chTNF-alpha and provide valuable immune reagents for studying inflammatory responses and disease pathogenesis in avian species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Plant Sciences
Zhao-Cong Wang, Yan Wang, Li-Ying Huang, Xiao-Jian Liao, Zhi-Hui Jiang, Shi-Hai Xu, Bing-Xin Zhao
Summary: Two new halogenated metabolites were isolated from the red alga Laurencia sp., and their structures were determined. In addition, the antibacterial activities of these metabolites were evaluated.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Kengo Kanayama, Jun Kato, Wataru Shiratori, Ariki Nagashima, Yuki Ohta, Takashi Taida, Keiko Saito, Chihiro Goto, Satsuki Takahashi, Ryosuke Horio, Akane Kurosugi, Tsubasa Ishikawa, Tatsuya Kaneko, Naoki Akizue, Kenichiro Okimoto, Tomoaki Matsumura, Naoya Kato
Summary: This study found that selecting subsequent treatment based on the response to initial anti-tumor necrosis factor (TNF)alpha antibody (ATA) is feasible in refractory ulcerative colitis (UC) patients. Non-ATA may be suitable as subsequent biologics for UC patients regardless of the efficacy of the first ATA.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Kuluvar Gouthannchandra, Heggar Venkataramana Sudeep, Siddappa Chandrappa, Amrith Raj, Puttaswamy Naveen, Kodimule Shyamaprasad
Summary: In this study, bisdemethoxycurcumin (BDMC) was enriched to 70% and named as REVERC3 for the first time, showing significant anti-inflammatory activity in comparison to regular turmeric extract. The results demonstrated that REVERC3 effectively inhibited inflammation processes in both in vitro and in vivo models.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Medicinal
Kyriakos C. Prousis, Stefanos Kikionis, Efstathia Ioannou, Silvia Morgana, Marco Faimali, Veronica Piazza, Theodora Calogeropoulou, Vassilios Roussis
Summary: Marine biofouling is a global issue that causes significant economic problems for the shipping industry and aquaculture companies, and its prevention often leads to adverse environmental effects. In this study, bromosphaerol and its derivatives were found to have strong antifouling activity and low toxicity, making them potential candidates for the development of effective antifouling agents.
Article
Chemistry, Medicinal
Mohamed A. A. Tammam, Maria G. G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. C. Kampranis, Christos Tsatsanis, Vassilios Roussis, Efstathia Ioannou
Summary: The chemical investigation of the organic extract of the red alga Laurencia majuscula resulted in the isolation of several new natural products with significant anti-inflammatory activity. The structures and configurations of these natural products were determined through NMR, MS, and single-crystal X-ray diffraction analysis. The most prominent anti-inflammatory activity was exhibited by compounds 5 and 18.
Article
Chemistry, Medicinal
Maria G. Daskalaki, Konstantinos Axarlis, Antiopi Tsoureki, Sofia Michailidou, Christina Efraimoglou, Ioanna Lapi, Ourania Kolliniati, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki, Anagnostis Argiriou, Christos Tsatsanis
Summary: Obesity and type 2 diabetes can be partially controlled with protein-containing nutritional supplements derived from fish sidestreams. This study examined the effects of dietary supplementation with different protein hydrolysates from fish on obesity, diabetes, and the gut microbiome in a mouse model. The results showed that specific protein hydrolysates had beneficial effects, such as suppressing glucose intolerance and promoting changes in the gut microbiome composition.
Article
Chemistry, Medicinal
Stefanos Kikionis, Paraskevi Papakyriakopoulou, Panagiotis Mavrogiorgis, Elena A. A. Vasileva, Natalia P. P. Mishchenko, Sergey A. A. Fedoreyev, Georgia Valsami, Efstathia Ioannou, Vassilios Roussis
Summary: By incorporating Echinochrome A (EchA) isolated from sea urchins into electrospun micro-/nanofibrous matrices composed of polycaprolactone and polyvinylpyrrolidone, the dissolution and bioavailability of EchA can be improved, making it suitable for oral administration, while also increasing its stability and solubility.
Article
Endocrinology & Metabolism
Christos Tsatsanis, Angel Elenkov, Irene Leijonhufvud, Katerina Vaporidi, Asa Tivesten, Aleksander Giwercman
Summary: Sex hormones and sex chromosomes have different impacts on cytokines involved in sex-dependent inflammatory response. The concentration of BAFF and LPS-stimulated TNF secretion depends on sex hormone levels, while basal TNF is regulated by both sex hormone-dependent and -independent factors.
ENDOCRINE CONNECTIONS
(2023)
Article
Chemistry, Medicinal
Stefanos Kikionis, Konstantina Iliou, Aikaterini G. Karra, Georgios Polychronis, Ioannis Choinopoulos, Hermis Iatrou, George Eliades, Efthymia Kitraki, Ioulia Tseti, Spiros Zinelis, Efstathia Ioannou, Vassilios Roussis
Summary: Nanofibrous GTR/GBR membranes based on carrageenans and other biocompatible polymers were developed for the regeneration of periodontal tissue. The membranes exhibited favorable morphological, thermal, and mechanical properties, and demonstrated the potential for periodontal tissue regeneration through evaluation of cell attachment, biocompatibility, and osteogenic differentiation.
Article
Chemistry, Medicinal
Paolo Giaccio, Despoina Charou, Dafni-Ioanna Diakaki, Anna Chita, Achille Gravanis, Ioannis Charalampopoulos, Vassilios Roussis, Efstathia Ioannou
Summary: Neurodegenerative diseases are incurable and debilitating conditions. Currently, effective therapies for most neurodegenerative disorders are lacking. A study evaluated the activity of various extracts on TrkB-expressing cells and found that a certain strain of actinobacteria called Streptomyces sp. BI0788 exhibited neuroprotective activity. Further chemical analysis resulted in the identification of new and previously known compounds, some of which showed protective effects on cells through the activation of TrkB.
Article
Biochemistry & Molecular Biology
Yao-Tao Duan, Aikaterini Koutsaviti, Maria Harizani, Codruta Ignea, Vassilios Roussis, Yong Zhao, Efstathia Ioannou, Sotirios C. Kampranis
Summary: By combining gene mining, biochemical characterization, and chemical structure analysis, this study reveals the existence of an extensive class of terpenoids with 16 carbon atoms in bacteria.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Horticulture
Junou He, Joao Paulo Alves Placido, Irini Pateraki, Sotirios Kampranis, Bruno Trevenzoli Favero, Henrik Lutken
Summary: Currently, the production of the anticancer drug paclitaxel is limited due to the low accumulation levels in yew plants. However, the use of hairy root culture as a biotechnological tool could be a cost-effective and efficient way to produce paclitaxel, making it of great importance in the pharmaceutical industry.
Article
Nutrition & Dietetics
Maria G. Grammatikopoulou, Kalliopi K. Gkouskou, Konstantinos Gkiouras, Dimitrios P. Bogdanos, Aristides G. Eliopoulos, Dimitrios G. Goulis
Summary: n-of-1 clinical trials are considered the epitome of individualized healthcare, providing evidence-based personalized obesity treatment through trial and error, reducing non-responders, and tailoring the best intervention for each patient.
CURRENT NUTRITION REPORTS
(2022)