Establishment of an <i>in vitro</i> cholestasis risk assessment system using two-dimensional cultured HepaRG cells and 12 bile acids

Challenges and Future of Drug-Induced Liver Injury Research—Laboratory Tests

(2022) Sabine Weber et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanism-based integrated assay systems for the prediction of drug-induced liver injury

(2020) Moemi Kawaguchi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms and in vitro models of drug-induced cholestasis

(2019) Eva Gijbels et al.   ARCHIVES OF TOXICOLOGY

In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome

(2019) Yoko Sakai et al.   Drug Metabolism and Pharmacokinetics

Development of an in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-C4 cells in sandwich configuration

(2019) Yoko Sakai et al.   TOXICOLOGY IN VITRO

Metabolic Activation of Cholestatic Drug-Induced Bile Acid-Dependent Toxicity in Human Sandwich-Cultured Hepatocytes

(2017) Eiichiro Ogimura et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Identification of Bile Acids Responsible for Inhibiting the Bile Salt Export Pump, Leading to Bile Acid Accumulation and Cell Toxicity in Rat Hepatocytes

(2017) Kumiko Oizumi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells

(2017) Matthew Gibson Burbank et al.   TOXICOLOGICAL SCIENCES

A modified multiparametric assay using HepaRG cells for predicting the degree of drug-induced liver injury risk

(2016) Takafumi Tomida et al.   JOURNAL OF APPLIED TOXICOLOGY

Establishment of a Drug-Induced, Bile Acid–Dependent Hepatotoxicity Model Using HepaRG Cells

(2016) Takeshi Susukida et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes

(2016) Marlies Oorts et al.   TOXICOLOGY IN VITRO

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

(2016) Ahmad Sharanek et al.   Scientific Reports

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro

(2015) Wim F.P.M. Van den Hof et al.   TOXICOLOGY IN VITRO

Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes

(2015) Takeshi Susukida et al.   TOXICOLOGY IN VITRO

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

(2014) Sreenivasa C. Ramaiahgari et al.   ARCHIVES OF TOXICOLOGY

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

(2014) Michael D. Aleo et al.   HEPATOLOGY

Drug-induced Acute Liver Failure

(2013) William M. Lee   Clinics in Liver Disease

Sandwich-cultured hepatocytes: utility forin vitroexploration of hepatobiliary drug disposition and drug-induced hepatotoxicity

(2013) Tom De Bruyn et al.   Expert Opinion on Drug Metabolism & Toxicology

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

(2013) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Influence of sildenafil and tadalafil on the enzyme- and transporter-inducing effects of bosentan and ambrisentan in LS180 cells

(2012) Johanna Weiss et al.   BIOCHEMICAL PHARMACOLOGY

Bile acid profiling in human biological samples: Comparison of extraction procedures and application to normal and cholestatic patients

(2012) Lydie Humbert et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells

(2012) John Gatfield et al.   PLoS One

Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle

(2012) Francisca Molina-Jimenez et al.   VIROLOGY

Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes

(2011) Eiichiro Ogimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: A pilot study

(2011) Jocelyn Trottier et al.   DIGESTIVE AND LIVER DISEASE

Sitaxentan-related acute liver failure in a patient with pulmonary arterial hypertension

(2011) W.-T. N. Lee et al.   EUROPEAN RESPIRATORY JOURNAL

Evaluation of Drugs With Specific Organ Toxicities in Organ-Specific Cell Lines

(2011) Zhiwu Lin et al.   TOXICOLOGICAL SCIENCES

Rapid quantification of bile acids and their conjugates in serum by liquid chromatography–tandem mass spectrometry

(2009) Max Scherer et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

(2009) Miia Turpeinen et al.   TOXICOLOGY IN VITRO

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES