Journal
CELL REPORTS
Volume 22, Issue 9, Pages 2359-2369Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2018.02.018
Keywords
-
Categories
Funding
- March of Dimes [6-FY17-315]
- NIH [R01GM112783]
- NIH Training Grant [T32GM007288]
- Developmental Studies Hybridoma Bank (DSHB)
- NY Genome Center
- Cancer Center Support Grant [P30 CA013330]
Ask authors/readers for more resources
Mutations in KDM5 family histone demethylases cause intellectual disability in humans. However, the molecular mechanisms linking KDM5-regulated transcription and cognition remain unknown. Here, we establish Drosophila as a model to understand this connection by generating a fly strain harboring an allele analogous to a disease-causing missense mutation in human KDM5C (kdm5(A512P)). Transcriptome analysis of kdm5(A512P) flies revealed a striking downregulation of genes required for ribosomal assembly and function and a concomitant reduction in translation. kdm5(A512P) flies also showed impaired learning and/or memory. Significantly, the behavioral and transcriptional changes in kdm5(A512P) flies were similar to those specifically lacking demethylase activity. These data suggest that the primary defect of the KDM5(A512P) mutation is a loss of histone demethylase activity and reveal an unexpected role for this enzymatic function in gene activation. Because translation is critical for neuronal function, we propose that this defect contributes to the cognitive defects of kdm5(A512P) flies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available