m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells

The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression

(2019) Mengru Zhuang et al.   NUCLEIC ACIDS RESEARCH

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

(2019) Huiwen Song et al.   Autophagy

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

SREBP Plays a Regulatory Role in LH/hCG Receptor mRNA Expression in Human Granulosa-Lutein cells

(2019) Yin-Xia Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

(2019) Xinyao Lin et al.   Nature Communications

Functional analysis of recombinant single-chain Japanese eel Fsh and Lh produced in FreeStyle 293-F cell lines: Binding specificities to their receptors and differential efficacy on testicular steroidogenesis

(2019) Hiroshi Suzuki et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels

(2018) Yabing Chen et al.   AQUATIC TOXICOLOGY

Defective autophagy degradation and abnormal tight junction-associated signaling drive epithelial dysfunction in cystinosis

(2018) Alessandro Luciani et al.   Autophagy

Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells

(2018) Fengyi Gao et al.   JOURNAL OF CELL BIOLOGY

Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins

(2018) Deepak P. Patil et al.   TRENDS IN CELL BIOLOGY

m6A RNA modification controls autophagy through upregulating ULK1 protein abundance

(2018) Shouheng Jin et al.   CELL RESEARCH

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells

(2018) Huifeng Pi et al.   Autophagy

Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

(2018) Yunshu Wu et al.   Nature Communications

Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis

(2017) Yabing Chen et al.   ENVIRONMENTAL POLLUTION

Circadian rhythm genes mediate fenvalerate-induced inhibition of testosterone synthesis in mouse Leydig cells

(2017) Yichen Guo et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Late-onset hypogonadism

(2017) Piotr Dudek et al.   Przeglad Menopauzalny

Identification of late-onset hypogonadism in middle-aged and elderly men from a community of China

(2016) Ying-Hao Sun et al.   ASIAN JOURNAL OF ANDROLOGY

Autophagy is required for ectoplasmic specialization assembly in sertoli cells

(2016) Chao Liu et al.   Autophagy

TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages

(2016) Nunzia Pastore et al.   Autophagy

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling

(2016) Hyowon Choi et al.   Autophagy

Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice

(2016) Wenqiang Ma et al.   CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

(2016) Irmgard U. Haussmann et al.   NATURE

m6A modulates neuronal functions and sex determination in Drosophila

(2016) Tina Lence et al.   NATURE

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N6-methyladenosine–encoded epitranscriptomics

(2016) Nian Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB

(2016) Xuesong Li et al.   Cell Death & Disease

N6-methyladenosine–encoded epitranscriptomics

(2016) Nian Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intracellular calcium signaling regulates autophagy via calcineurin-mediated TFEB dephosphorylation

(2015) Yanju Tong et al.   Autophagy

Lysosomal calcium regulates autophagy

(2015) Diego L Medina et al.   Autophagy

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming

(2015) Francesca Aguilo et al.   Cell Stem Cell

Testosterone in men with advanced liver disease: Abnormalities and implications

(2015) Marie Sinclair et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

AMPK: energy sensor and survival mechanism in the ischemic heart

(2015) Dake Qi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA

(2013) Ye Fu et al.   Nature Communications

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex

(2012) K. Padmanabhan et al.   SCIENCE

Autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells

(2011) Wei-Ren Li et al.   ASIAN JOURNAL OF ANDROLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Leydig cells: From stem cells to aging

(2009) Haolin Chen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Investigation, treatment and monitoring of late-onset hypogonadism in males

(2008) C Wang et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Leydig cell aging and the mechanisms of reduced testosterone synthesis

(2008) Andrew S. Midzak et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY