The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation

Novel Method for Quantifying AhR-Ligand Binding Affinities Using Microscale Thermophoresis

(2021) Anne Stinn et al.   Biosensors-Basel

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Catalytic Atroposelective C7 Functionalisation of Indolines and Indoles

(2021) Saad Shaaban et al.   CHEMISTRY-A EUROPEAN JOURNAL

Host monitoring of quorum sensing during Pseudomonas aeruginosa infection

(2020) Pedro Moura-Alves et al.   SCIENCE

Rh(III)‐catalyzed C‐H Activation of Aryl‐Hydroxamates for the Synthesis of Isoindolinones

(2020) Herbert Waldmann et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chiral cyclopentadienyl ligands: design, syntheses and applications in asymmetric catalysis

(2020) Nicolai Cramer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of Chiral Cyclopentadienyl (Cpx) Metal Complexes in Asymmetric Catalysis

(2020) Saad Shaaban et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Aryl Hydrocarbon Receptor in Mesenchymal Stromal Cells: New Frontiers in AhR Biology

(2020) Kristopher K. Abney et al.   FEBS Journal

VolcaNoseR is a web app for creating, exploring, labeling and sharing volcano plots

(2020) Joachim Goedhart et al.   Scientific Reports

Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells

(2019) Louis M. Luttrell et al.   PLoS One

Aldehyde Dehydrogenases: Not Just Markers, but Functional Regulators of Stem Cells

(2019) Giuseppe Vassalli   Stem Cells International

Chemical Genetics Reveals a Role of dCTP Pyrophosphatase 1 in Wnt Signaling

(2019) Alexandra Friese et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis

(2019) Laura Lozza et al.   Scientific Reports

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

(2019) Lea Kremer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

QMEANDisCo – Distance Constraints Applied on Model Quality Estimation

(2019) Gabriel Studer et al.   BIOINFORMATICS

A highlight on Sonic hedgehog pathway

(2018) Gabriela Basile Carballo et al.   Cell Communication and Signaling

Integrated Omics: Tools, Advances, and Future Approaches

(2018) Biswapriya B Misra et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Experimental evidence for an inhibitory role of AhR activation in human mesenchymal stem cell differentiation

(2018) AtLee T D Watson et al.   TOXICOLOGICAL SCIENCES

Comparative analysis of interactions between aryl hydrocarbon receptor ligand binding domain with its ligands: a computational study

(2018) Kumaraswamy Naidu Chitrala et al.   BMC STRUCTURAL BIOLOGY

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation

(2017) Kathrin Wiebke Schulte et al.   STRUCTURE

The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis

(2016) Takashi Izawa et al.   JOURNAL OF IMMUNOLOGY

Access Path to the Ligand Binding Pocket May Play a Role in Xenobiotics Selection by AhR

(2016) Dániel Szöllősi et al.   PLoS One

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Hide and seek: Identification and confirmation of small molecule protein targets

(2015) Andrei Ursu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

(2015) Jayme L. Dahlin et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Aggregation Advisor for Ligand Discovery

(2015) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Developing predictive assays: The phenotypic screening “rule of 3”

(2015) Fabien Vincent et al.   Science Translational Medicine

SHELXT– Integrated space-group and crystal-structure determination

(2015) George M. Sheldrick   Acta Crystallographica A-Foundation and Advances

Crystal structure refinement withSHELXL

(2015) George M. Sheldrick   Acta Crystallographica Section C-Structural Chemistry

Signaling pathways regulating the specification and differentiation of the osteoblast lineage

(2015) Hironori Hojo et al.   Regenerative Therapy

AhR sensing of bacterial pigments regulates antibacterial defence

(2014) Pedro Moura-Alves et al.   NATURE

A practical enantioselective total synthesis of (−)-(S)-stepholidine

(2014) Suo Gao et al.   TETRAHEDRON LETTERS

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear Receptors in Bone Physiology and Diseases

(2013) Yuuki Imai et al.   PHYSIOLOGICAL REVIEWS

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

(2012) Timothy V. Beischlag et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

(2012) Xiaojun Lian et al.   Nature Protocols

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

(2012) N. Huang et al.   SCIENCE

Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation

(2012) T. K. Hyster et al.   SCIENCE

Chiral Cyclopentadienyl Ligands as Stereocontrolling Element in Asymmetric C-H Functionalization

(2012) B. Ye et al.   SCIENCE

Identification of the Ah-Receptor Structural Determinants for Ligand Preferences

(2012) Yongna Xing et al.   TOXICOLOGICAL SCIENCES

New Aryl Hydrocarbon Receptor Homology Model Targeted To Improve Docking Reliability

(2011) Ilaria Motto et al.   Journal of Chemical Information and Modeling

KNIME Workflow to Assess PAINS Filters in SMARTS Format. Comparison of RDKit and Indigo Cheminformatics Libraries

(2011) Simon Saubern et al.   Molecular Informatics

The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling

(2011) Jianing Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

(2011) Michael S. Denison et al.   TOXICOLOGICAL SCIENCES

Methoxy- and acetoxy-8-oxoberbines - synthesis, antitumor activity, and interaction with DNA

(2010) Christian Weimar et al.   ARCHIV DER PHARMAZIE

Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution

(2010) Jeremy R. Greenwood et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

A decade of chemical biology

(2010) Mirella Bucci et al.   Nature Chemical Biology

The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells

(2010) Irene Ma et al.   Stem Cell Reviews and Reports

CH223191 Is a Ligand-Selective Antagonist of the Ah (Dioxin) Receptor

(2010) Bin Zhao et al.   TOXICOLOGICAL SCIENCES

Detection of the TCDD Binding-Fingerprint within the Ah Receptor Ligand Binding Domain by Structurally Driven Mutagenesis and Functional Analysis

(2009) Alessandro Pandini et al.   BIOCHEMISTRY

Dioxins interfere with differentiation of osteoblasts and osteoclasts

(2009) Merja Korkalainen et al.   BONE

OLEX2: a complete structure solution, refinement and analysis program

(2009) Oleg V. Dolomanov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY