Body Fat Distribution, Fasting Insulin Levels, and Insulin Secretion: A Bidirectional Mendelian Randomization Study

The energy balance model of obesity: beyond calories in, calories out

(2022) Kevin D Hall et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots

(2022) Saaket Agrawal et al.   Nature Communications

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

(2021) Vasiliki Lagou et al.   Nature Communications

Are Mendelian randomization investigations immune from bias due to reverse causation?

(2021) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

The genetics of obesity: from discovery to biology

(2021) Ruth J. F. Loos et al.   NATURE REVIEWS GENETICS

Pleiotropy robust methods for multivariable Mendelian randomization

(2021) Andrew J. Grant et al.   STATISTICS IN MEDICINE

Taking a closer look at metabolically healthy obesity

(2021) Jean-Pierre Després   Nature Reviews Endocrinology

Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity

(2020) Robert Ross et al.   Nature Reviews Endocrinology

A comparison of robust Mendelian randomization methods using summary data

(2020) Eric A. W. Slob et al.   GENETIC EPIDEMIOLOGY

Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study

(2020) Tengfei Man et al.   JOURNAL OF HYPERTENSION

Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses

(2020) Chris Wallace   PLoS Genetics

MR-Clust: Clustering of genetic variants in Mendelian randomization with similar causal estimates

(2020) Christopher N Foley et al.   BIOINFORMATICS

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

(2020) Ana Viñuela et al.   Nature Communications

Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement

(2019) Ian J Neeland et al.   Lancet Diabetes & Endocrinology

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity

(2018) Christina M. Astley et al.   CLINICAL CHEMISTRY

Insulin therapy, weight gain and prognosis

(2018) Israel Hodish   DIABETES OBESITY & METABOLISM

Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain

(2018) Melissa M. Page et al.   FASEB JOURNAL

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Mild Suppression of Hyperinsulinemia to Treat Obesity and Insulin Resistance

(2018) Melissa M. Page et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry

(2018) Sara L Pulit et al.   HUMAN MOLECULAR GENETICS

An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings

(2018) Eleanor Sanderson et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

(2017) Gijs H. Goossens   Obesity Facts

Evaluation of waist-to-height ratio as a predictor of insulin resistance in non-diabetic obese individuals. A cross-sectional study

(2017) Giovana Jamar et al.   Sao Paulo Medical Journal

A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization

(2017) Jack Bowden et al.   STATISTICS IN MEDICINE

Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy

(2017) Jessica M. B. Rees et al.   STATISTICS IN MEDICINE

Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men

(2016) Kevin D Hall et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Mendelian Randomization and Type 2 Diabetes

(2016) Daniel I. Swerdlow   CARDIOVASCULAR DRUGS AND THERAPY

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents

(2016) Jerri Chiu Yun Ling et al.   Scientific Reports

C‐Reactive Protein Identifies Low‐Risk Metabolically Healthy Obese Persons: The European Prospective Investigation of Cancer–Norfolk Prospective Population Study

(2016) Diederik F. van Wijk et al.   Journal of the American Heart Association

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

(2015) S. Burgess et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity

(2015) Kevin D. Hall et al.   Cell Metabolism

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity

(2015) Nicole M. Templeman et al.   DIABETOLOGIA

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

(2014) D. J. Hodson et al.   DIABETES

Factors Associated With Weight Gain in People With Type 2 Diabetes Starting on Insulin

(2014) Beverley Balkau et al.   DIABETES CARE

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

A Central Role for GRB10 in Regulation of Islet Function in Man

(2014) Inga Prokopenko et al.   PLoS Genetics

Insulin signalling mechanisms for triacylglycerol storage

(2013) M. P. Czech et al.   DIABETOLOGIA

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Effect of antidiabetic agents added to metformin on glycaemic control, hypoglycaemia and weight change in patients with type 2 diabetes: a network meta-analysis

(2012) S.-C. Liu et al.   DIABETES OBESITY & METABOLISM

Avoiding bias from weak instruments in Mendelian randomization studies

(2011) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

(2010) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES