Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain

A causal role for hyperinsulinemia in obesity

(2017) Nicole M Templeman et al.   JOURNAL OF ENDOCRINOLOGY

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

(2017) Nicole M. Templeman et al.   Cell Reports

Current Perspectives on Long-term Obesity Pharmacotherapy

(2016) Sean Wharton   Canadian Journal of Diabetes

Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation

(2016) Marta Szabat et al.   Cell Metabolism

Lipodystrophy Due to Adipose Tissue–Specific Insulin Receptor Knockout Results in Progressive NAFLD

(2016) Samir Softic et al.   DIABETES

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function

(2016) Jeremie Boucher et al.   DIABETES

The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity

(2016) Laurène Vetterli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan in adipose tissue: Beyond dermal filler and therapeutic carrier

(2016) Yi Zhu et al.   Science Translational Medicine

Preventing High Fat Diet-induced Obesity and Improving Insulin Sensitivity through Neuregulin 4 Gene Transfer

(2016) Yongjie Ma et al.   Scientific Reports

Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells

(2016) Tobias Boothe et al.   Molecular Metabolism

Personalized Nutrition by Prediction of Glycemic Responses

(2015) David Zeevi et al.   CELL

Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes

(2015) Christopher J. Nolan et al.   DIABETES

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity

(2015) Nicole M. Templeman et al.   DIABETOLOGIA

Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells

(2015) Paymon M. Azizi et al.   MOLECULAR BIOLOGY OF THE CELL

Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome

(2015) Robert H. Lustig et al.   Obesity

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

(2014) Meritxell Rosell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Caveolin-1 Expression and Cavin Stability Regulate Caveolae Dynamics in Adipocyte Lipid Store Fluctuation

(2014) N. Briand et al.   DIABETES

Chronic Reduction of GIP Secretion Alleviates Obesity and Insulin Resistance Under High-Fat Diet Conditions

(2014) D. Nasteska et al.   DIABETES

Neural innervation of white adipose tissue and the control of lipolysis

(2014) Timothy J. Bartness et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Transcriptional fingerprinting of “browning” white fat identifies NRG4 as a novel adipokine

(2014) Mark Christian   Adipocyte

Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance

(2013) L. Kang et al.   DIABETES

Insulin signalling mechanisms for triacylglycerol storage

(2013) M. P. Czech et al.   DIABETOLOGIA

Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

(2012) Arya E. Mehran et al.   Cell Metabolism

Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling

(2012) Jeremie Boucher et al.   Nature Communications

The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model

(2011) Heather A. Lawson et al.   MAMMALIAN GENOME

Adipose Tissue Deficiency and Chronic Inflammation in Diabetic Goto-Kakizaki Rats

(2011) Bai Xue et al.   PLoS One

Reciprocal modulation of adult beta cell maturity by activin A and follistatin

(2010) M. Szabat et al.   DIABETOLOGIA

Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling

(2010) Sarah L. Gray et al.   ENDOCRINOLOGY

The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women

(2010) M N Harvie et al.   INTERNATIONAL JOURNAL OF OBESITY

Diet-Dependent Genetic and Genomic Imprinting Effects on Obesity in Mice

(2010) James M. Cheverud et al.   Obesity

Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy

(2009) Yukiko K. Hayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

(2008) Michelle M. Hill et al.   CELL

Deletion of Cavin/PTRF Causes Global Loss of Caveolae, Dyslipidemia, and Glucose Intolerance

(2008) Libin Liu et al.   Cell Metabolism

Diazoxide enhances basal metabolic rate and fat oxidation in obese Zucker rats

(2008) Ramin Alemzadeh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL