Standardized method for mechanistic modeling of multimodal anion exchange chromatography in flow through operation

Using multimodal chromatography for post-conjugation antibody-drug conjugate purification: A methodology from high throughput screening to in-silico process development

(2021) William R. Keller et al.   JOURNAL OF CHROMATOGRAPHY A

Straightforward method for calibration of mechanistic cation exchange chromatography models for industrial applications

(2020) David Saleh et al.   BIOTECHNOLOGY PROGRESS

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

Modeling of hydrophobic interaction chromatography for the separation of antibody-drug conjugates and its application towards quality by design

(2020) Sebastian Andris et al.   JOURNAL OF BIOTECHNOLOGY

Effects of molecule size and resin structure on protein adsorption on multimodal anion exchange chromatography media

(2020) Joey A. Roberts et al.   JOURNAL OF CHROMATOGRAPHY A

Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. I. Experimental observations and phenomenological model

(2019) Lucas K. Kimerer et al.   JOURNAL OF CHROMATOGRAPHY A

Mechanistic modeling based process development for monoclonal antibody monomer-aggregate separations in multimodal cation exchange chromatography

(2019) Ling Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

Good modeling practice for industrial chromatography: Mechanistic modeling of ion exchange chromatography of a bispecific antibody

(2019) Federico Rischawy et al.   COMPUTERS & CHEMICAL ENGINEERING

Conformational changes of antibodies upon adsorption onto hydrophobic interaction chromatography surfaces

(2018) Beate Beyer et al.   JOURNAL OF CHROMATOGRAPHY A

Multimodal Chromatography for Purification of Biotherapeutics – A Review

(2018) Vivek Halan et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Prediction uncertainty assessment of chromatography models using Bayesian inference

(2018) Till Briskot et al.   JOURNAL OF CHROMATOGRAPHY A

A versatile noninvasive method for adsorber quantification in batch and column chromatography based on the ionic capacity

(2016) Thiemo C. Huuk et al.   BIOTECHNOLOGY PROGRESS

Thermodynamic modeling of protein retention in mixed-mode chromatography: An extended model for isocratic and dual gradient elution chromatography

(2016) Yi Feng Lee et al.   JOURNAL OF CHROMATOGRAPHY A

Protein adsorption equilibrium and kinetics in multimodal cation exchange resins

(2015) Mimi Zhu et al.   ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY

Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model

(2015) Arch Creasy et al.   Biotechnology Journal

UV absorption-based inverse modeling of protein chromatography

(2015) Tobias Hahn et al.   ENGINEERING IN LIFE SCIENCES

Simulating and Optimizing Preparative Protein Chromatography with ChromX

(2015) Tobias Hahn et al.   JOURNAL OF CHEMICAL EDUCATION

Adsorption equilibrium and kinetics of monomer–dimer monoclonal antibody mixtures on a cation exchange resin

(2015) Jason M. Reck et al.   JOURNAL OF CHROMATOGRAPHY A

Modeling of dual gradient elution in ion exchange and mixed-mode chromatography

(2015) Yi Feng Lee et al.   JOURNAL OF CHROMATOGRAPHY A

Combined Yamamoto approach for simultaneous estimation of adsorption isotherm and kinetic parameters in ion-exchange chromatography

(2015) Matthias Rüdt et al.   JOURNAL OF CHROMATOGRAPHY A

Linear isotherm determination from linear gradient elution experiments

(2015) David Pfister et al.   JOURNAL OF CHROMATOGRAPHY A

Solvent modulated linear pH gradient elution for the purification of conventional and bispecific antibodies: Modeling and application

(2015) Simon Kluters et al.   JOURNAL OF CHROMATOGRAPHY A

Alternative molecular formats and therapeutic applications for bispecific antibodies

(2015) Christoph Spiess et al.   MOLECULAR IMMUNOLOGY

Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model

(2015) Arch Creasy et al.   Biotechnology Journal

Model-based process development for the purification of a modified human growth hormone using multimodal chromatography

(2014) Lars Sejergaard et al.   BIOTECHNOLOGY PROGRESS

Adjoint-based estimation and optimization for column liquid chromatography models

(2014) Tobias Hahn et al.   COMPUTERS & CHEMICAL ENGINEERING

Multimodal chromatography: Characterization of protein binding and selectivity enhancement through mobile phase modulators

(2014) Leslie S. Wolfe et al.   JOURNAL OF CHROMATOGRAPHY A

Purifying biopharmaceuticals: knowledge-based chromatographic process development

(2014) Alexander T. Hanke et al.   TRENDS IN BIOTECHNOLOGY

Systematic generation of buffer systems for pH gradient ion exchange chromatography and their application

(2013) Frieder Kröner et al.   JOURNAL OF CHROMATOGRAPHY A

Methods development in multimodal chromatography with mobile phase modifiers using the steric mass action model

(2013) Hanne Sophie Karkov et al.   JOURNAL OF CHROMATOGRAPHY A

Evaluating antibody monomer separation from associated aggregates using mixed-mode chromatography

(2013) Dong Gao et al.   JOURNAL OF CHROMATOGRAPHY A

Multimodal chromatography: An efficient tool in downstream processing of proteins

(2012) Kristian Kallberg et al.   Biotechnology Journal

Determination of parameters for the steric mass action model—A comparison between two approaches

(2012) A. Osberghaus et al.   JOURNAL OF CHROMATOGRAPHY A

The need for innovation in biomanufacturing

(2012) Uwe Gottschalk et al.   NATURE BIOTECHNOLOGY

Antibody capture by mixed-mode chromatography: A comprehensive study from determination of optimal purification conditions to identification of contaminating host cell proteins

(2011) Jerome Pezzini et al.   JOURNAL OF CHROMATOGRAPHY A

Effective electrophoretic mobilities and charges of anti-VEGF proteins determined by capillary zone electrophoresis

(2011) S. Kevin Li et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Downstream bioprocessing: recent advances and future promise

(2011) Steven M Cramer et al.   Current Opinion in Chemical Engineering

Application of mixed mode resins for the purification of antibodies

(2010) Agnes Voitl et al.   JOURNAL OF CHROMATOGRAPHY A

High-throughput isotherm determination and thermodynamic modeling of protein adsorption on mixed mode adsorbents

(2010) Beckley K. Nfor et al.   JOURNAL OF CHROMATOGRAPHY A

Model-Based Experimental Analysis of a Fixed-Bed Reactor for Catalytic SO2Oxidation

(2009) J. C. Schöneberger et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Ligands for mixed-mode protein chromatography: Principles, characteristics and design

(2009) Guofeng Zhao et al.   JOURNAL OF BIOTECHNOLOGY

A new thermodynamic model describes the effects of ligand density and type, salt concentration and protein species in hydrophobic interaction chromatography

(2009) R.W. Deitcher et al.   JOURNAL OF CHROMATOGRAPHY A

The distinctive separation attributes of mixed-mode resins and their application in monoclonal antibody downstream purification process

(2009) Jie Chen et al.   JOURNAL OF CHROMATOGRAPHY A

A Review of the Thermodynamics of Protein Association to Ligands, Protein Adsorption, and Adsorption Isotherms

(2008) J. M. Mollerup   CHEMICAL ENGINEERING & TECHNOLOGY