Using multimodal chromatography for post-conjugation antibody-drug conjugate purification: A methodology from high throughput screening to in-silico process development

Modeling of hydrophobic interaction chromatography for the separation of antibody-drug conjugates and its application towards quality by design

(2020) Sebastian Andris et al.   JOURNAL OF BIOTECHNOLOGY

Antibody–Drug Conjugates: Future Directions in Clinical and Translational Strategies to Improve the Therapeutic Index

(2019) Steven Coats et al.   CLINICAL CANCER RESEARCH

Mechanistic modeling based process development for monoclonal antibody monomer-aggregate separations in multimodal cation exchange chromatography

(2019) Ling Zhang et al.   JOURNAL OF CHROMATOGRAPHY A

Antibody–drug conjugates for cancer

(2019) Cindy H Chau et al.   LANCET

Antibody-Drug Conjugates: A Comprehensive Review

(2019) Puregmaa Khongorzul et al.   MOLECULAR CANCER RESEARCH

Kinetic reaction modeling for antibody-drug conjugate process development

(2019) Sebastian Andris et al.   JOURNAL OF BIOTECHNOLOGY

Multi-step high-throughput conjugation platform for the development of antibody-drug conjugates

(2018) Sebastian Andris et al.   JOURNAL OF BIOTECHNOLOGY

Bioprocess development of antibody-drug conjugate production for cancer treatment

(2018) Jianfa Ou et al.   PLoS One

Understanding operational system differences for transfer of miniaturized chromatography column data using simulations

(2017) William R. Keller et al.   JOURNAL OF CHROMATOGRAPHY A

Monoclonal antibody fragment removal mediated by mixed mode resins

(2017) Ellen O’Connor et al.   JOURNAL OF CHROMATOGRAPHY A

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Development of Commercial-Ready Processes for Antibody Drug Conjugates

(2017) Xi Hu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

(2017) Ricarda M. Hoffmann et al.   OncoImmunology

New developments for antibody-drug conjugate-based therapeutic approaches

(2016) Bart ECG de Goeij et al.   CURRENT OPINION IN IMMUNOLOGY

Antibody–drug conjugates for cancer therapy

(2016) Anish Thomas et al.   LANCET ONCOLOGY

Processes for Constructing Homogeneous Antibody Drug Conjugates

(2016) David Y. Jackson   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

(2016) Kyoji Tsuchikama et al.   Protein & Cell

Investigation of protein selectivity in multimodal chromatography usingin silicodesigned Fab fragment variants

(2015) Hanne Sophie Karkov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Use of MiniColumns for linear isotherm parameter estimation and prediction of benchtop column performance

(2015) William R. Keller et al.   JOURNAL OF CHROMATOGRAPHY A

The effect of geometrical presentation of multimodal cation-exchange ligands on selective recognition of hydrophobic regions on protein surfaces

(2015) James Woo et al.   JOURNAL OF CHROMATOGRAPHY A

Evaluation of selectivity in homologous multimodal chromatographic systems using in silico designed antibody fragment libraries

(2015) Hanne Sophie Karkov et al.   JOURNAL OF CHROMATOGRAPHY A

Defining the property space for chromatographic ligands from a homologous series of mixed-mode ligands

(2015) James A. Woo et al.   JOURNAL OF CHROMATOGRAPHY A

Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides

(2015) R. James Christie et al.   JOURNAL OF CONTROLLED RELEASE

Interactions of Multimodal Ligands with Proteins: Insights into Selectivity Using Molecular Dynamics Simulations

(2015) Siddharth Parimal et al.   LANGMUIR

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Long-Term Stabilization of Maleimide–Thiol Conjugates

(2014) Shaun D. Fontaine et al.   BIOCONJUGATE CHEMISTRY

Model-based process development for the purification of a modified human growth hormone using multimodal chromatography

(2014) Lars Sejergaard et al.   BIOTECHNOLOGY PROGRESS

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

(2014) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Methods development in multimodal chromatography with mobile phase modifiers using the steric mass action model

(2013) Hanne Sophie Karkov et al.   JOURNAL OF CHROMATOGRAPHY A

Determination of parameters for the steric mass action model—A comparison between two approaches

(2012) A. Osberghaus et al.   JOURNAL OF CHROMATOGRAPHY A

Effects of Urea on Selectivity and Protein–Ligand Interactions in Multimodal Cation Exchange Chromatography

(2012) Melissa A. Holstein et al.   LANGMUIR

Mobile phase modifier effects in multimodal cation exchange chromatography

(2011) Melissa A. Holstein et al.   BIOTECHNOLOGY AND BIOENGINEERING

Model-based rational strategy for chromatographic resin selection

(2011) Beckley K. Nfor et al.   BIOTECHNOLOGY PROGRESS

High-throughput isotherm determination and thermodynamic modeling of protein adsorption on mixed mode adsorbents

(2010) Beckley K. Nfor et al.   JOURNAL OF CHROMATOGRAPHY A

High-throughput screening of chromatographic separations: IV. Ion-exchange

(2008) Brian D. Kelley et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-throughput screening of chromatographic separations: III. Monoclonal antibodies on ceramic hydroxyapatite

(2008) David L. Wensel et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-throughput screening of chromatographic separations: I. Method development and column modeling

(2008) Jonathan L. Coffman et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-Throughput Process Development: Determination of Dynamic Binding Capacity Using Microtiter Filter Plates Filled with Chromatography Resin

(2008) T. Bergander et al.   BIOTECHNOLOGY PROGRESS

High Throughput Screening for the Design and Optimization of Chromatographic Processes: Assessment of Model Parameter Determination from High Throughput Compatible Data

(2008) A. Susanto et al.   CHEMICAL ENGINEERING & TECHNOLOGY

High Throughput Screening for the Design and Optimization of Chromatographic Processes: Automated Optimization of Chromatographic Phase Systems

(2008) A. Susanto et al.   CHEMICAL ENGINEERING & TECHNOLOGY