Renal Inflammation and Fibrosis: A Double-edged Sword

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

Inflammation and renal fibrosis: Recent developments on key signaling molecules as potential therapeutic targets

(2018) Wenshan Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis

(2018) Anja Thorenz et al.   KIDNEY INTERNATIONAL

Assessment of tumor necrosis factor alpha polymorphism TNF-α−238 (rs 361525) as a risk factor for development of acute kidney injury in critically ill patients

(2018) Sameer H. Fatani et al.   MOLECULAR BIOLOGY REPORTS

Increased transforming growth factor beta (TGF-β) and pSMAD3 signaling in a Murine Model for Contrast Induced Kidney Injury

(2018) Sreenivasulu Kilari et al.   Scientific Reports

Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications

(2018) Sujuan Yang et al.   Frontiers in Immunology

Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney

(2018) Amrutesh S. Puranik et al.   Scientific Reports

Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis

(2018) Atsuko Y. Higashi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review

(2018) Suhana Ahmad et al.   Frontiers in Immunology

Interleukin-33 signaling contributes to renal fibrosis following ischemia reperfusion

(2017) Hua Liang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis

(2017) Jessica M. Overstreet et al.   FASEB JOURNAL

Blocking TGF-βandβ-Catenin Epithelial Crosstalk Exacerbates CKD

(2017) Stellor Nlandu-Khodo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A new CTGF target in renal fibrosis

(2017) John R. Montford et al.   KIDNEY INTERNATIONAL

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

(2017) Liyu He et al.   KIDNEY INTERNATIONAL

Parabiosis reveals leukocyte dynamics in the kidney

(2017) Jeremie M Lever et al.   LABORATORY INVESTIGATION

Protection of tubular epithelial cells during renal injury via post-transcriptional control of BMP7

(2017) Jiping Sun et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

T cells and autoimmune kidney disease

(2017) Abel Suárez-Fueyo et al.   Nature Reviews Nephrology

Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys

(2017) Abbas Dehnadi et al.   Nature Communications

Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice

(2017) Elodie Mintet et al.   Scientific Reports

Crucial Role of Mesangial Cell-derived Connective Tissue Growth Factor in a Mouse Model of Anti-Glomerular Basement Membrane Glomerulonephritis

(2017) Naohiro Toda et al.   Scientific Reports

Upregulation of Interleukin-33 in obstructive renal injury

(2016) Wei-Yu Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages

(2016) Efstathios G. Stamatiades et al.   CELL

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

(2016) Yu Bo Yang Sun et al.   DIFFERENTIATION

Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury

(2016) Irina A. Leaf et al.   JOURNAL OF CLINICAL INVESTIGATION

Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery

(2016) D. E. Leaf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI

(2016) J. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1βand IL-18 and Arrests CKD

(2016) Hazel H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endothelial Sphingosine 1-Phosphate Receptor-1 Mediates Protection and Recovery from Acute Kidney Injury

(2016) H. M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of PDGF-D in healthy and fibrotic kidneys

(2016) Eva M. Buhl et al.   KIDNEY INTERNATIONAL

Recognition and management of acute kidney injury in the International Society of Nephrology 0by25 Global Snapshot: a multinational cross-sectional study

(2016) Ravindra L Mehta et al.   LANCET

Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors

(2016) Michael M. Kaminski et al.   NATURE CELL BIOLOGY

Expression and Function of the Epidermal Growth Factor Receptor in Physiology and Disease

(2016) Jianchun Chen et al.   PHYSIOLOGICAL REVIEWS

Epithelial Plasticity versus EMT in Kidney Fibrosis

(2016) Shizheng Huang et al.   TRENDS IN MOLECULAR MEDICINE

The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases

(2016) Qingjie Chen et al.   Acta Pharmaceutica Sinica B

Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

(2016) Sonsoles Piera-Velazquez et al.   Journal of Clinical Medicine

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

(2015) Robert B. Good et al.   AMERICAN JOURNAL OF PATHOLOGY

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis

(2015) Rafael Kramann et al.   JOURNAL OF CLINICAL INVESTIGATION

Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury

(2015) A. Bajwa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Heme Oxygenase-1 Regulates Myeloid Cell Trafficking in AKI

(2015) T. D. Hull et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps

(2015) H. Rabb et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage and epithelial cell H-ferritin expression regulates renal inflammation

(2015) Subhashini Bolisetty et al.   KIDNEY INTERNATIONAL

Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury

(2015) Yinqiu Wang et al.   KIDNEY INTERNATIONAL

TGF-β/Smad3 signalling regulates the transition of bone marrowderived macrophages into myofibroblasts during tissue fibrosis

(2015) Shuang Wang et al.   Oncotarget

Functional significance of mononuclear phagocyte populations generated through adult hematopoiesis

(2014) Michael F. Gutknecht et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-22 Ameliorates Renal Ischemia-Reperfusion Injury by Targeting Proximal Tubule Epithelium

(2014) M.-J. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-Like Receptor 4-Induced IL-22 Accelerates Kidney Regeneration

(2014) O. P. Kulkarni et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Novel targets of antifibrotic and anti-inflammatory treatment in CKD

(2014) Anne-Emilie Declèves et al.   Nature Reviews Nephrology

Omeprazole-induced acute interstitial nephritis: A possible Th1-Th17-mediated injury?

(2014) Linda Berney-Meyer et al.   NEPHROLOGY

Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury

(2014) G. Canaud et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

(2014) Lakhmir S. Chawla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Homeostasis in the mononuclear phagocyte system

(2014) Stephen J. Jenkins et al.   TRENDS IN IMMUNOLOGY

EGFR signaling in renal fibrosis

(2014) Shougang Zhuang et al.   Kidney International Supplements

Platelet-derived growth factors (PDGFs) in glomerular and tubulointerstitial fibrosis

(2014) Tammo Ostendorf et al.   Kidney International Supplements

Heme oxygenase-1 and acute kidney injury

(2013) Karl A. Nath   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury

(2013) Abolfazl Zarjou et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis

(2013) Benjamin D. Humphreys et al.   JOURNAL OF CLINICAL INVESTIGATION

Resident Renal Mononuclear Phagocytes Comprise Five Discrete Populations with Distinct Phenotypes and Functions

(2013) T. Kawakami et al.   JOURNAL OF IMMUNOLOGY

Renal Ischemia-Reperfusion Injury Amplifies the Humoral Immune Response

(2013) R. Fuquay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage Phenotype Controls Long-Term AKI Outcomes--Kidney Regeneration versus Atrophy

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Messengers without Borders: Mediators of Systemic Inflammatory Response in AKI

(2013) B. B. Ratliff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NADPH Oxidases, Reactive Oxygen Species, and the Kidney: Friend and Foe

(2013) M. Sedeek et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model

(2013) Barbara Reich et al.   KIDNEY INTERNATIONAL

Role of epidermal growth factor receptor in acute and chronic kidney injury

(2013) Jinhua Tang et al.   KIDNEY INTERNATIONAL

Interleukin-10 deficiency aggravates kidney inflammation and fibrosis in the unilateral ureteral obstruction mouse model

(2013) Yuanmeng Jin et al.   LABORATORY INVESTIGATION

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Differentiated kidney epithelial cells repair injured proximal tubule

(2013) T. Kusaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 levels in patients with acute kidney injury: a cross sectional study

(2013) Oskar Zakiyanov et al.   BMC Nephrology

Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis

(2013) Keizo Kanasaki et al.   Frontiers in Endocrinology

Cytokine mediated tissue fibrosis

(2012) Lee A. Borthwick et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CSF-1 signaling mediates recovery from acute kidney injury

(2012) Ming-Zhi Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution

(2012) Eric S White et al.   JOURNAL OF PATHOLOGY

Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration

(2012) Bart Smeets et al.   JOURNAL OF PATHOLOGY

Deleting the TGF-  Receptor Attenuates Acute Proximal Tubule Injury

(2012) L. Gewin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury

(2012) Jianchun Chen et al.   KIDNEY INTERNATIONAL

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

How Does TGF-β Mediate Tubulointerstitial Fibrosis?

(2012) Leslie Gewin et al.   SEMINARS IN NEPHROLOGY

Targeting Pericyte Differentiation as a Strategy to Modulate Kidney Fibrosis in Diabetic Nephropathy

(2012) Benjamin D. Humphreys   SEMINARS IN NEPHROLOGY

Characterization of Renal Progenitors Committed Toward Tubular Lineage and Their Regenerative Potential in Renal Tubular Injury

(2012) Maria Lucia Angelotti et al.   STEM CELLS

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

(2011) Sonsoles Piera-Velazquez et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β/TGF-β receptor system and its role in physiological and pathological conditions

(2011) Juan F. Santibañez et al.   CLINICAL SCIENCE

Fibroblasts and myofibroblasts in renal fibrosis

(2011) Soma Meran et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

EGFR Signaling Promotes TGF -Dependent Renal Fibrosis

(2011) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury

(2011) Lihua Bao et al.   KIDNEY INTERNATIONAL

Tubular Overexpression of Transforming Growth Factor-β1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells

(2010) Robert Koesters et al.   AMERICAN JOURNAL OF PATHOLOGY

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis

(2010) Sonali Sonnylal et al.   ARTHRITIS AND RHEUMATISM

B Cell Subsets Contribute to Renal Injury and Renal Protection after Ischemia/Reperfusion

(2010) B. Renner et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells contribute to the protective effect of ischemic preconditioning in the kidney

(2010) Gilbert R. Kinsey et al.   KIDNEY INTERNATIONAL

Acute interstitial nephritis

(2010) Manuel Praga et al.   KIDNEY INTERNATIONAL

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Renal fibrosis: novel insights into mechanisms and therapeutic targets

(2010) Peter Boor et al.   Nature Reviews Nephrology

Urinary excretion of soluble tumour necrosis factor receptor 1 as a marker of increased risk of progressive kidney function deterioration in patients with primary chronic glomerulonephritis

(2010) I. Idasiak-Piechocka et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Macrophage Wnt7b is critical for kidney repair and regeneration

(2010) S.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice

(2009) Julia Menke et al.   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

The renin–angiotensin system contributes to renal fibrosis through regulation of fibrocytes

(2009) Norihiko Sakai et al.   JOURNAL OF HYPERTENSION

CTGF Promotes Inflammatory Cell Infiltration of the Renal Interstitium by Activating NF- B

(2009) E. Sanchez-Lopez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ferritin Prevents Calcification and Osteoblastic Differentiation of Vascular Smooth Muscle Cells

(2009) A. Zarjou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulatory T Cells Suppress Innate Immunity in Kidney Ischemia-Reperfusion Injury

(2009) G. R. Kinsey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury

(2009) Maria Teresa Gandolfo et al.   KIDNEY INTERNATIONAL

Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury

(2009) Alaa S. Awad et al.   KIDNEY INTERNATIONAL

Role of CX3C-chemokine CX3C-L/fractalkine expression in a model of slowly progressive renal failure

(2009) M. J. Koziolek et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

(2009) Jaklien C. Leemans et al.   PLoS One

Identification of Markers that Distinguish Monocyte-Derived Fibrocytes from Monocytes, Macrophages, and Fibroblasts

(2009) Darrell Pilling et al.   PLoS One

Regulatory effects of ferritin on angiogenesis

(2009) L. G. Coffman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

The innate immune response in ischemic acute kidney injury

(2008) Hye Ryoun Jang et al.   CLINICAL IMMUNOLOGY

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL

The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease

(2008) Kevin S. Eardley et al.   KIDNEY INTERNATIONAL

The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia–reperfusion injury

(2008) Li Li et al.   KIDNEY INTERNATIONAL

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY