Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

(2022) Diego Angosto-Bazarra et al.   BMC BIOLOGY

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis

(2022) Wanyan Deng et al.   NATURE

Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes

(2022) Doris L. LaRock et al.   NATURE

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

(2022) Hongxu Xian et al.   IMMUNITY

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

(2021) Bowen Zhou et al.   Cell Reports

Chemical Modulation of Gasdermin-Mediated Pyroptosis and Therapeutic Potential

(2021) Christopher B. Ryder et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases

(2020) Danbin Wu et al.   Journal of Cell Communication and Signaling

Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage

(2020) Zhonghua Liu et al.   IMMUNITY

Bioactive Plasma Mitochondrial DNA is Associated with Disease Progression in Scleroderma Associated Interstitial Lung Disease

(2020) Changwan Ryu et al.   Arthritis & Rheumatology

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

Changes in macrophage transcriptome associate with systemic sclerosis and mediateGSDMAcontribution to disease risk

(2018) Aida Moreno-Moral et al.   ANNALS OF THE RHEUMATIC DISEASES

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Detection of anti-mitochondrial antibodies by immunoprecipitation in patients with systemic sclerosis

(2018) Angela Ceribelli et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

(2018) Hiroto Kambara et al.   Cell Reports

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Live-cell visualization of gasdermin D-driven pyroptotic cell death

(2017) Joseph K. Rathkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

(2017) Kinlin L. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Synthetic Biology Reveals the Uniqueness of the RIP Kinase Domain

(2016) Steven M. Chirieleison et al.   JOURNAL OF IMMUNOLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Loss of conservedGsdma3self-regulation causes autophagy and cell death

(2015) Peiliang Shi et al.   BIOCHEMICAL JOURNAL

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Cardiolipin and Its Different Properties in Mitophagy and Apoptosis

(2015) Xiao-Xiao Li et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

(2015) Kiyoshi Itagaki et al.   PLoS One

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Gsdma3I359N is a novel ENU-induced mutant mouse line for studying the function of Gasdermin A3 in the hair follicle and epidermis

(2012) Sudhir Kumar et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE