6-Shogaol Overcomes Gefitinib Resistance via ER Stress in Ovarian Cancer Cells

6‐ shogaol suppresses AOM/DSS‐mediated colorectal adenoma through its antioxidant and anti‐inflammatory effects in mice

(2022) Olufunke Florence Ajeigbe et al.   JOURNAL OF FOOD BIOCHEMISTRY

Effect of Ginger on Inflammatory Diseases

(2022) Pura Ballester et al.   MOLECULES

Endoplasmic Reticulum Stress Contributes to Gefitinib-Induced Apoptosis in Glioma

(2021) Cheng-Yi Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells

(2021) Nipin Sp et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanism of hepatotoxicity of first-line tyrosine kinase inhibitors: Gefitinib and afatinib

(2021) Yao Zhang et al.   TOXICOLOGY LETTERS

Phenethyl isothiocyanate synergistically induces apoptosis with Gefitinib in non–small cell lung cancer cells via endoplasmic reticulum stress‐mediated degradation of Mcl‐1

(2020) Qicheng Zhang et al.   MOLECULAR CARCINOGENESIS

Omega-3 Fatty Acid-Enriched Fish Oil and Selenium Combination Modulates Endoplasmic Reticulum Stress Response Elements and Reverses Acquired Gefitinib Resistance in HCC827 Lung Adenocarcinoma Cells

(2020) Chien-Huang Liao et al.   Marine Drugs

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

(2019) Hai Hu et al.   Frontiers in Immunology

Role of Endoplasmic Reticulum Stress in the Anticancer Activity of Natural Compounds

(2019) Patrizia Limonta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overcoming acquired resistance of gefitinib in lung cancer cells without T790M by AZD9291 or Twist1 knockdown in vitro and in vivo

(2019) Zhongwei Liu et al.   ARCHIVES OF TOXICOLOGY

The third-generation EGFR inhibitor AZD9291 overcomes primary resistance by continuously blocking ERK signaling in glioblastoma

(2019) Xuejiao Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells

(2019) Donghwa Kim et al.   Cell Death & Disease

Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)

(2019) Qian-Qian Mao et al.   Foods

Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response

(2019) Yuning Lin et al.   BIOMEDICINE & PHARMACOTHERAPY

Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET

(2019) Ha-Na Oh et al.   PHYTOMEDICINE

Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review

(2018) Changmin Kim et al.   Nutrients

Flavonoids in Cancer and Apoptosis

(2018) Mariam Abotaleb et al.   Cancers

MiR-106b inhibitors sensitize TRAIL-induced apoptosis in hepatocellular carcinoma through increase of death receptor 4

(2017) Changlong Xu et al.   Oncotarget

Radiation Treatment in Women with Ovarian Cancer: Past, Present, and Future

(2017) Emma C. Fields et al.   Frontiers in Oncology

Chemoprevention in gastrointestinal physiology and disease. Targeting the progression of cancer with natural products: a focus on gastrointestinal cancer

(2016) Roxane Khoogar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Anticancer Potential of Ginger: Mechanistic and Pharmaceutical Aspects

(2016) Indu Pal Kaur et al.   CURRENT PHARMACEUTICAL DESIGN

Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress

(2016) ZHONGLIANG WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Antitumor effects of herbal mixture extract in the pancreatic adenocarcinoma cell line PANC1

(2016) Pyo June Pak et al.   ONCOLOGY REPORTS

Dietary Natural Products for Prevention and Treatment of Liver Cancer

(2016) Yue Zhou et al.   Nutrients

Overcome Cancer Cell Drug Resistance Using Natural Products

(2015) Pu Wang et al.   Evidence-based Complementary and Alternative Medicine

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

(2015) SHUNTARO MUKAI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A reactive oxygen species activation mechanism contributes to JS-K-induced apoptosis in human bladder cancer cells

(2015) Mingning Qiu et al.   Scientific Reports

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting antioxidants for cancer therapy

(2014) Andrea Glasauer et al.   BIOCHEMICAL PHARMACOLOGY

Roles of Epithelial-Mesenchymal Transition in Cancer Drug Resistance

(2014) Yulong Shang et al.   CURRENT CANCER DRUG TARGETS

Antitumor activity of combination treatment with gefitinib and docetaxel in EGFR-TKI-sensitive, primary resistant and acquired resistant human non-small cell lung cancer cells

(2014) MIN WU et al.   Molecular Medicine Reports

Combination of Gefitinib and DNA Methylation Inhibitor Decitabine Exerts Synergistic Anti-Cancer Activity in Colon Cancer Cells

(2014) Yun-feng Lou et al.   PLoS One

Ginger: Is it Ready for Prime Time?

(2013) G. D. Stoner   Cancer Prevention Research

Acquired Resistance to EGFR Inhibitors Is Associated with a Manifestation of Stem Cell-like Properties in Cancer Cells

(2013) K. Shien et al.   CANCER RESEARCH

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy

(2012) Shengpeng Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

(2012) Zhenfeng Zhang et al.   NATURE GENETICS

Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: Involvement of ROS-dependent ER-stress

(2011) Dong-Oh Moon et al.   BIOCHEMICAL PHARMACOLOGY

Activation of ER stress and inhibition of EGFR N-glycosylation by tunicamycin enhances susceptibility of human non-small cell lung cancer cells to erlotinib

(2009) Yi-He Ling et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells

(2009) Jen-Yu Hung et al.   LUNG CANCER

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Endoplasmic Reticulum Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to Epidermal Growth Factor Receptor Inhibitors

(2008) Y.-C. Wang et al.   CANCER RESEARCH

Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways

(2008) Fung-Ming Siu et al.   PROTEOMICS

Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research

(2007) Badreldin H. Ali et al.   FOOD AND CHEMICAL TOXICOLOGY