Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Narirutin via Block of Nav1.7 Voltage-Gated Sodium Channel

Calcitonin Gene-Related Peptide (CGRP)-Targeted Monoclonal Antibodies and Antagonists in Migraine: Current Evidence and Rationale

(2022) Fred Cohen et al.   BIODRUGS

Prospective multifunctional roles and pharmacological potential of dietary flavonoid narirutin

(2022) Saikat Mitra et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

(2022) Fahadul Islam et al.   Evidence-based Complementary and Alternative Medicine

Nerve growth factor-mediated Na+ channel plasticity of bladder afferent neurons in mice with spinal cord injury

(2022) Jianshu Ni et al.   LIFE SCIENCES

Targeted muscle reinnervation prevents and reverses rat pain behaviors following nerve transection

(2022) Elizabeth Roth et al.   PAIN

Profile of dorsal root ganglion neurons: study of oxytocin expression

(2022) Taisei Noguri et al.   Molecular Brain

The emerging role of quercetin in the treatment of chronic pain

(2022) Cheng Liu et al.   Current Neuropharmacology

Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8

(2022) Xiaoshuang Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analgesic Action of Catechin on Chronic Constriction Injury–Induced Neuropathic Pain in Sprague–Dawley Rats

(2022) Ahmed I. Foudah et al.   Frontiers in Pharmacology

IL-10 alleviates radicular pain by inhibiting TNF-α/p65 dependent Nav1.7 up-regulation in DRG neurons of rats

(2022) Yangliang Huang et al.   BRAIN RESEARCH

Pharmacological features, health benefits and clinical implications of honokiol

(2022) Fatima Khatoon et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Efficacy of 2-Hydroxyflavanone in Rodent Models of Pain and Inflammation: Involvement of Opioidergic and GABAergic Anti-Nociceptive Mechanisms

(2022) Faiz Ali Khan et al.   MOLECULES

Study of the dermal anti-inflammatory, antioxidant, and analgesic activity of pinostrobin

(2022) Alejandro Serna González et al.   Heliyon

Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7

(2021) Elizabeth J Akin et al.   BRAIN

Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKCε in rat dorsal root ganglion neurons

(2021) Jing Xu et al.   Journal of Neuroinflammation

Conventional Dorsal Root Ganglion Stimulation in an Experimental Model of Painful Diabetic Peripheral Neuropathy: A Quantitative Immunocytochemical Analysis of Intracellular γ‐Aminobutyric Acid in Dorsal Root Ganglion Neurons

(2021) Glenn Franken et al.   NEUROMODULATION

Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase‐1 Inhibitors by Automated De Novo Design

(2021) Lukas Friedrich et al.   Advanced Science

Pain sensing neurons promote tissue regeneration in adult mice

(2021) Lise Rabiller et al.   npj Regenerative Medicine

An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery

(2020) Zainab A. Mohammed et al.   PAIN

Lidocaine Binding Enhances Inhibition of Nav1.7 Channels by the Sulfonamide PF-05089771

(2020) Sooyeon Jo et al.   MOLECULAR PHARMACOLOGY

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

(2019) Hui Xu et al.   CELL

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

Voltage-gated sodium channels: structures, functions, and molecular modeling

(2019) Lei Xu et al.   DRUG DISCOVERY TODAY

The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels

(2019) Yuan Zhou et al.   ACS Chemical Neuroscience

Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain

(2018) Erin E. Krebs et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Yield of peripheral sodium channels gene screening in pure small fibre neuropathy

(2018) Ivo Eijkenboom et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain

(2017) Yan Li et al.   JOURNAL OF NEUROSCIENCE

Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay

(2017) Antoine Fouillet et al.   Molecular Pain

Loperamide inhibits sodium channels to alleviate inflammatory hyperalgesia

(2017) Ying Wu et al.   NEUROPHARMACOLOGY

Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons

(2017) Zainab A. Mohammed et al.   Scientific Reports

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function

(2016) Erik T. Dustrude et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy

(2014) Simon Haroutounian et al.   PAIN

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

(2013) Cédric J. Laedermann et al.   JOURNAL OF CLINICAL INVESTIGATION

Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation

(2012) Sang Keun Ha et al.   FOOD AND CHEMICAL TOXICOLOGY

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN