Cytoplasmic Expression of TP53INP2 Modulated by Demethylase FTO and Mutant NPM1 Promotes Autophagy in Leukemia Cells

Insights into N6-methyladenosine and programmed cell death in cancer

(2022) Li Liu et al.   Molecular Cancer

Mutant NPM1-Regulated FTO-Mediated m6A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling Axis

(2022) Qiaoling Xiao et al.   Frontiers in Oncology

The dual role of autophagy in acute myeloid leukemia

(2022) Wonhyoung Seo et al.   Journal of Hematology & Oncology

L3MBTL2-mediated CGA transcriptional suppression promotes pancreatic cancer progression through modulating autophagy

(2022) Hua Huang et al.   iScience

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

(2021) Ying Qing et al.   MOLECULAR CELL

Oxidative stress induces downregulation of TP53INP2 and suppresses osteogenic differentiation of BMSCs during osteoporosis through the autophagy degradation pathway

(2021) Yuehua Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells

(2021) Xun Lai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG

(2021) Liu-shan Chen et al.   ACTA PHARMACOLOGICA SINICA

NOVEL NPM1 EXON 5 MUTATIONS AND GENE FUSIONS LEADING TO ABERRANT CYTOPLASMIC NUCLEOPHOSMIN IN AML

(2021) Maria Paola Martelli et al.   BLOOD

miR-142-3p Regulates Tumor Cell Autophagy and Promotes Colon Cancer Progression by Targeting TP53INP2

(2021) Jiujian Zheng et al.   CHEMOTHERAPY

The bifunctional role of TP53INP2 in transcription and autophagy

(2020) Yinfeng Xu et al.   Autophagy

Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells

(2020) Reza Ghasemi et al.   LEUKEMIA

The potential role of RNA N6-methyladenosine in Cancer progression

(2020) Tianyi Wang et al.   Molecular Cancer

NPM1-mutated acute myeloid leukemia: from bench to bedside

(2020) Brunangelo Falini et al.   BLOOD

TP53INP2 Modulates Epithelial-to-Mesenchymal Transition via the GSK-3β/β-Catenin/Snail1 Pathway in Bladder Cancer Cells

(2020) Zhengtao Zhou et al.   OncoTargets and Therapy

TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction

(2019) Zhiyuan You et al.   Autophagy

Regulation of death receptor signaling by the autophagy protein TP53INP2

(2019) Saška Ivanova et al.   EMBO JOURNAL

TP 53 INP 2 mediates autophagic degradation of ubiquitinated proteins through its ubiquitin‐interacting motif

(2019) Yinfeng Xu et al.   FEBS LETTERS

PU.1 subcellular localization in acute myeloid leukaemia with mutated NPM1

(2019) Giulia Pianigiani et al.   BRITISH JOURNAL OF HAEMATOLOGY

Functions of N6-methyladenosine and its role in cancer

(2019) Liuer He et al.   Molecular Cancer

Mutant NPM1 Maintains the Leukemic State through HOX Expression

(2018) Lorenzo Brunetti et al.   CANCER CELL

Biological and clinical consequences of NPM1 mutations in AML

(2017) E M Heath et al.   LEUKEMIA

NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells

(2017) Qin Zou et al.   Theranostics

Targeting autophagy to overcome chemoresistance in acute myleogenous leukemia

(2016) Sujan Piya et al.   Autophagy

Autophagy, a key mechanism of oncogenesis and resistance in leukemia

(2016) Patrick Auberger et al.   BLOOD

Acute myeloid leukaemia

(2016) Asim Khwaja et al.   Nature Reviews Disease Primers

TP53INP2/DOR protein chaperones deacetylated nuclear LC3 to the cytoplasm to promote macroautophagy

(2015) Xu Liu et al.   Autophagy

Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes

(2014) David Sala et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model

(2013) P. Sportoletti et al.   BLOOD

Correction: DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription

(2012) Ana Sancho et al.   PLoS One

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TP53INP2 is the new guest at the table of self-eating

(2009) Jonathan Nowak et al.   Autophagy

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

(2009) K. Cheng et al.   BLOOD

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells

(2009) Caroline Mauvezin et al.   EMBO REPORTS

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications

(2009) B Falini et al.   LEUKEMIA

Tumor Protein 53-Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

(2008) C. E. Cano et al.   CANCER RESEARCH

Nucleophosmin Interacts with HEXIM1 and Regulates RNA Polymerase II Transcription

(2008) Meera Gurumurthy et al.   JOURNAL OF MOLECULAR BIOLOGY