The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG

Juvenile-onset multifocal osteonecrosis in systemic lupus erythematosus

(2021) Wenyuan Jin et al.   MEDICINE

METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export

(2020) Di Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA m 6 A methylation regulates sorafenib resistance in liver cancer through FOXO 3‐mediated autophagy

(2020) Ziyou Lin et al.   EMBO JOURNAL

Methyltransferase‐like 3‐mediated N6‐methyladenosine modification of miR‐7212‐5p drives osteoblast differentiation and fracture healing

(2020) Bobin Mi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA

(2020) Sara Zaccara et al.   CELL

The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor

(2020) Yiren Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Drug Therapy and Drug Discontinuations and Holidays for Osteoporosis Fracture Prevention

(2019) Howard A. Fink et al.   ANNALS OF INTERNAL MEDICINE

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

(2019) Yue Huang et al.   CANCER CELL

Down-regulation of exosomal microRNA-224-3p derived from bone marrow–derived mesenchymal stem cells potentiates angiogenesis in traumatic osteonecrosis of the femoral head

(2019) Hai-Jia Xu et al.   FASEB JOURNAL

The role of lncRNA RP11‐154D6 in steroid‐induced osteonecrosis of the femoral head through BMSC regulation

(2019) Shuai Xiang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

(2019) Seungwon Yang et al.   Nature Communications

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

(2019) Xinxia Wang et al.   Autophagy

BMSC-derived exosomes carrying microRNA-122-5p promote proliferation of osteoblasts in osteonecrosis of the femoral head

(2019) Wen Liao et al.   CLINICAL SCIENCE

LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c/SATB2 axis

(2019) Xucheng Yang et al.   Aging-US

Ostéonécroses aseptiques, une revue générale des ostéonécroses de la hanche, et au-delà

(2019) L. Pijnenburg et al.   REVUE DE MEDECINE INTERNE

Screening for Osteoporosis to Prevent Fractures

(2018) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

N 6 -methyladenosine modification: a novel pharmacological target for anti-cancer drug development

(2018) Yi Niu et al.   Acta Pharmaceutica Sinica B

The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis

(2018) Guang-Si Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

(2018) Yunshu Wu et al.   Nature Communications

Complex Relationship between Obesity and the Fat Mass and Obesity Locus

(2017) Qingyun Yang et al.   International Journal of Biological Sciences

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

(2016) Robert A Adler et al.   JOURNAL OF BONE AND MINERAL RESEARCH

m6A modulates neuronal functions and sex determination in Drosophila

(2016) Tina Lence et al.   NATURE

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

RNAN6-methyladenosine methylation in post-transcriptional gene expression regulation

(2015) Yanan Yue et al.   GENES & DEVELOPMENT

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO

(2015) Joel D. W. Toh et al.   Chemical Science

Pharmacological repression of PPARγ promotes osteogenesis

(2015) David P. Marciano et al.   Nature Communications

The bone–fat interface: basic and clinical implications of marrow adiposity

(2015) Maureen J Devlin et al.   Lancet Diabetes & Endocrinology

What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health

(2014) Erica L. Scheller et al.   Annals of the New York Academy of Sciences

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Osteonecrosis of the Femoral Head

(2014) Charalampos G. Zalavras et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

Osteoporosis-associated Fracture and Diabetes

(2013) Salila Kurra et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

The Transcriptional Profile of Mesenchymal Stem Cell Populations in Primary Osteoporosis Is Distinct and Shows Overexpression of Osteogenic Inhibitors

(2012) Peggy Benisch et al.   PLoS One

N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function

(2012) Yamei Niu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Atypical Fractures as a Potential Complication of Long-term Bisphosphonate Therapy

(2010) Deborah E. Sellmeyer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

The genetics of obesity: FTO leads the way

(2010) Katherine A. Fawcett et al.   TRENDS IN GENETICS

Fat targets for skeletal health

(2009) Masanobu Kawai et al.   Nature Reviews Rheumatology

Regenerative Effects of Transplanted Mesenchymal Stem Cells in Fracture Healing

(2009) Froilán Granero-Moltó et al.   STEM CELLS

Association of FTO With Obesity-Related Traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort

(2008) A. F. Marvelle et al.   DIABETES