Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia

A short-term treatment with resveratrol improves the inflammatory conditions of Middle-aged mice skeletal muscles

(2022) Giuseppe Sirago et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Self‐transducible LRS‐UNE‐L peptide enhances muscle regeneration

(2022) Mi‐Ock Baek et al.   Journal of Cachexia Sarcopenia and Muscle

SnapShot: Skeletal muscle atrophy

(2022) Leslie M. Baehr et al.   CELL

Fish Protein Promotes Skeletal Muscle Hypertrophy via the Akt/mTOR Signaling Pathways

(2022) Mizuki MORISASA et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

A Collagen Hydrolysate Containing Tripeptides Ameliorates Sarcopenia in Middle-Aged Mice

(2022) Ji-Eun Kim et al.   MOLECULES

Di-(2-ethyl hexyl) phthalate induced oxidative stress promotes microplastics mediated apoptosis and necroptosis in mice skeletal muscle by inhibiting PI3K/AKT/mTOR pathway

(2022) Xiaojing Liu et al.   TOXICOLOGY

Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project)

(2022) Roberto Bernabei et al.   BMJ-British Medical Journal

Lactococcus cremoris subsp. cremoris FC-fermented milk activates protein synthesis and increases skeletal muscle mass in middle-aged mice

(2022) Wataru Aoi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR

(2022) Paula Ketilly Nascimento Alves et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Maca on Muscle Hypertrophy in C2C12 Skeletal Muscle Cells

(2022) Dong Yi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.

(2022) Zanlin Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated mir-145-5p is associated with skeletal muscle dysfunction and triggers apoptotic cell death in C2C12 myotubes

(2022) Jing Jin et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

(2022) Xin Gu et al.   NATURE

The Contribution of Genetics to Muscle Disuse, Retraining, and Aging

(2022) Giuseppe Sirago et al.   Genes

Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

(2021) Roberta Sartori et al.   Nature Communications

The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver

(2021) Guglielmina Chimienti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-Coding RNAs in the Transcriptional Network That Differentiates Skeletal Muscles of Sedentary from Long-Term Endurance- and Resistance-Trained Elderly

(2021) Paola De Sanctis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance

(2021) Yuantong Liu et al.   BONE

Molecular routes to sarcopenia and biomarker development: per aspera ad astra

(2021) Anna Picca et al.   CURRENT OPINION IN PHARMACOLOGY

Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains

(2021) Hirofumi Nagao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC2 is an important target for simvastatin-associated toxicity in C2C12 cells and mouse skeletal muscle – Roles of Rap1 geranylgeranylation and mitochondrial dysfunction

(2021) Gerda M. Sanvee et al.   BIOCHEMICAL PHARMACOLOGY

Raptor is critical for increasing the mitochondrial proteome and skeletal muscle force during hypertrophy

(2021) Martina Baraldo et al.   FASEB JOURNAL

Inhibitory Effects of Chrysanthemum (Chrysanthemum morifolium Ramat.) Extract and Its Active Compound Isochlorogenic Acid A on Sarcopenia

(2021) Dowan Kwon et al.   Preventive Nutrition and Food Science

Alterations in Autophagy and Mammalian Target of Rapamycin (mTOR) Pathways Mediate Sarcopenia in Patients with Cirrhosis

(2021) Abhinav Anand et al.   Journal of Clinical and Experimental Hepatology

The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

(2020) Allison Ho Kowalsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

(2020) Jessica Segalés et al.   Nature Communications

Association between sarcopenia and levels of growth hormone and insulin-like growth factor-1 in the elderly

(2020) Ailin Bian et al.   BMC MUSCULOSKELETAL DISORDERS

Long-term resveratrol treatment improves the capillarization in the skeletal muscles of ageing C57BL/6J mice

(2020) Luana Toniolo et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Comparative Analyses of mTOR/Akt and Muscle Atrophy-Related Signaling in Aged Respiratory and Gastrocnemius Muscles

(2020) Kun Woo Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Signaling Pathways That Control Muscle Mass

(2020) Anna Vainshtein et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute rimonabant treatment promotes protein synthesis in C2C12 myotubes through a CB1‐independent mechanism

(2020) Olivier Le Bacquer et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

(2020) Daniel J. Ham et al.   Nature Communications

4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia

(2019) Olivier Le Bacquer et al.   Journal of Cachexia Sarcopenia and Muscle

Evidence for a Role for Sestrin1 in Mediating Leucine-Induced Activation of mTORC1 in Skeletal Muscle

(2019) Dandan Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism

(2019) Huibin Tang et al.   AGING CELL

Rapamycin protects aging muscle

(2019) Huibin Tang et al.   Aging-US

Serum Myostatin and IGF-1 as Gender-Specific Biomarkers of Frailty and Low Muscle Mass in Community-Dwelling Older Adults

(2019) Justin Chew et al.   Journal of Nutrition Health & Aging

Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men

(2019) Nima Gharahdaghi et al.   Journal of Cachexia Sarcopenia and Muscle

Phosphorylation of eukaryotic initiation factor 4E is dispensable for skeletal muscle hypertrophy

(2019) Vandre C. Figueiredo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Skeletal muscle mTORC1 regulates neuromuscular junction stability

(2019) Martina Baraldo et al.   Journal of Cachexia Sarcopenia and Muscle

Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles

(2019) Chiao-Nan Chen et al.   GeroScience

mTORC2 affects the maintenance of the muscle stem cell pool

(2019) Nathalie Rion et al.   Skeletal Muscle

Resveratrol treatment reduces the appearance of tubular aggregates and improves the resistance to fatigue in aging mice skeletal muscles

(2018) Luana Toniolo et al.   EXPERIMENTAL GERONTOLOGY

Prediction of sarcopenia using a combination of multiple serum biomarkers

(2018) Ju Yeon Kwak et al.   Scientific Reports

Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance

(2018) Alexis Ruiz et al.   Scientific Reports

The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy

(2018) Jae-Sung You et al.   FASEB JOURNAL

mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass

(2017) Mee-Sup Yoon   Frontiers in Physiology

High mTORC1 signaling is maintained, while protein degradation pathways are perturbed in old murine skeletal muscles in the fasted state

(2016) Zoe White et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

S6K1 Is Required for Increasing Skeletal Muscle Force during Hypertrophy

(2016) Manuela Marabita et al.   Cell Reports

Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women

(2015) Melissa M. Markofski et al.   EXPERIMENTAL GERONTOLOGY

The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2

(2015) Ekaterina I. Mokhonova et al.   HUMAN MOLECULAR GENETICS

Effect of aging on muscle mitochondrial substrate utilization in humans

(2015) Kitt Falk Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of human mTOR complex 1

(2015) C. H. S. Aylett et al.   SCIENCE

Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity

(2014) Debariya Dutta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice

(2014) Mitchell Barns et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

(2014) Jamie L. Barger et al.   PLoS One

Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius

(2013) Donna H. Korzick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

(2013) M. Sandri et al.   BIOGERONTOLOGY

A role for Raptor phosphorylation in the mechanical activation of mTOR signaling

(2013) John W. Frey et al.   CELLULAR SIGNALLING

Correction: Molecular Networks of Human Muscle Adaptation to Exercise and Age

(2013) Bethan E. Phillips et al.   PLoS Genetics

Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding

(2012) Anna Picca et al.   AGE

Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion

(2012) Michelle M. Farnfield et al.   Applied Physiology Nutrition and Metabolism

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

(2012) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

PKB signaling and atrogene expression in skeletal muscle of aged mice

(2011) Megan Gaugler et al.   JOURNAL OF APPLIED PHYSIOLOGY

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

(2011) Christopher S Fry et al.   Skeletal Muscle

Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1

(2010) Andrew Philp et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of aging and gender on muscle mass and regulation of Akt-mTOR-p70s6k related signaling in the F344BN rat model

(2010) Satyanarayana Paturi et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Lifelong Calorie Restriction Alleviates Age-Related Oxidative Damage in Peripheral Nerves

(2010) Katherine Opalach et al.   REJUVENATION RESEARCH

Gender influences neuromuscular adaptations to muscle unloading

(2009) Michael R. Deschenes et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

The mTORC2 Complex Regulates Terminal Differentiation of C2C12 Myoblasts

(2009) L. Shu et al.   MOLECULAR AND CELLULAR BIOLOGY

Raptor Swoops in on Metabolism

(2008) Reuben J. Shaw   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging

(2008) Micah J. Drummond et al.   JOURNAL OF APPLIED PHYSIOLOGY

Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis

(2008) Micah J. Drummond et al.   JOURNAL OF APPLIED PHYSIOLOGY

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE