Neuroprotective effects of melatonin‐mediated mitophagy through nucleotide‐binding oligomerization domain and leucine‐rich repeat‐containing protein X1 in neonatal hypoxic–ischemic brain damage

Melatonin Attenuates Ropivacaine-Induced Apoptosis by Inhibiting Excessive Mitophagy Through the Parkin/PINK1 Pathway in PC12 and HT22 Cells

(2022) Lian Zeng et al.   INFLAMMATION

Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1

(2022) Samuel A. Killackey et al.   MOLECULAR CELL

NLRX1/FUNDC1/NIPSNAP1‐2 axis regulates mitophagy and alleviates intestinal ischaemia/reperfusion injury

(2021) Shaoqin Li et al.   CELL PROLIFERATION

Melatonin for neuroprotection in neonatal encephalopathy: A systematic review & meta-analysis of clinical trials

(2021) Javed Ahmed et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Melatonin prevents diabetes‐associated cognitive dysfunction from microglia‐mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway

(2021) Yixin Cui et al.   FASEB JOURNAL

Targeting autophagy to modulate hepatic ischemia/reperfusion injury: A comparative study between octreotide and melatonin as autophagy modulators through AMPK/PI3K/AKT/mTOR/ULK1 and Keap1/Nrf2 signaling pathways in rats

(2021) Dina Zakaria Mohamed et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process

(2021) Yi-Zhou Tan et al.   Stem Cell Research & Therapy

Melatonin attenuates vascular calcification by activating autophagy via an AMPK/mTOR/ULK1 signaling pathway

(2020) Wei Ren Chen et al.   EXPERIMENTAL CELL RESEARCH

Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis

(2020) Jiapeng Bao et al.   Aging-US

Melatonin Plays a Critical Protective Role in Nicotine-Related Abdominal Aortic Aneurysm

(2020) Liren Duan et al.   Frontiers in Physiology

Mitophagy, Mitochondrial Homeostasis, and Cell Fate

(2020) Kaili Ma et al.   Frontiers in Cell and Developmental Biology

NLR in eXile: Emerging roles of NLRX1 in immunity and human disease

(2020) Robert J. Pickering et al.   IMMUNOLOGY

Melatonin and regulation of autophagy: Mechanisms and therapeutic implications

(2020) Jinjing Wu et al.   PHARMACOLOGICAL RESEARCH

Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K/AKT/mTOR axis

(2020) Guimin Zheng et al.   TISSUE & CELL

Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies

(2019) Justyna Paprocka et al.   International Journal of Endocrinology

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

(2019) Yifan Zhang et al.   NATURE IMMUNOLOGY

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

(2019) Mingming Tong et al.   CIRCULATION RESEARCH

Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care

(2019) Anna Tarocco et al.   Cell Death & Disease

NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-κB signaling

(2019) Ding Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1

(2018) Samuel A. Killackey et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells

(2018) Chih-Chao Chang et al.   Oxidative Medicine and Cellular Longevity

Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage

(2018) Bin Sun et al.   MEDICAL SCIENCE MONITOR

Mitochondrial Metabolism in Major Neurological Diseases

(2018) Zhengqiu Zhou et al.   Cells

Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

(2017) Claire Thornton et al.   FEBS LETTERS

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

(2017) Geurt Stokman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury

(2017) Michelle H. Theus et al.   JOURNAL OF IMMUNOLOGY

Rapid modulation of the silent information regulator 1 by melatonin after hypoxia-ischemia in the neonatal rat brain

(2017) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

(2017) Shenglong Cao et al.   Scientific Reports

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

(2016) Dun-Xian Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis

(2016) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy

(2016) Chao Lin et al.   JOURNAL OF PINEAL RESEARCH

NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation

(2016) Hongyan Li et al.   MOLECULAR IMMUNOLOGY

The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis

(2014) Fraser Soares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria: hub of injury responses in the developing brain

(2014) Henrik Hagberg et al.   LANCET NEUROLOGY

Nlrx1 regulates neuronal cell death

(2014) Emilie Imbeault et al.   Molecular Brain

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

(2013) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

(2012) Yu Lei et al.   IMMUNITY

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

(2009) D. Arnoult et al.   JOURNAL OF CELL SCIENCE

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE