NLRX1/FUNDC1/NIPSNAP1‐2 axis regulates mitophagy and alleviates intestinal ischaemia/reperfusion injury

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

(2020) Yingchuan Li et al.   CELL DEATH AND DIFFERENTIATION

Aggravated intestinal ischemia‑reperfusion injury is associated with activated mitochondrial autophagy in a mouse model of diabetes

(2020) Zi Zeng et al.   Molecular Medicine Reports

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

NIPSNAP1 and NIPSNAP2 Act as “Eat Me” Signals for Mitophagy

(2019) Yakubu Princely Abudu et al.   DEVELOPMENTAL CELL

NLRX1 Is a Multifaceted and Enigmatic Regulator of Immune System Function

(2019) Margaret A. Nagai-Singer et al.   Frontiers in Immunology

NLRX1 Regulation Following Acute Mitochondrial Injury

(2019) Xiaogang Chu et al.   Frontiers in Immunology

Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fission

(2019) Jin Wang et al.   Redox Biology

NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

(2018) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

Mst1 promotes cardiac ischemia–reperfusion injury by inhibiting the ERK-CREB pathway and repressing FUNDC1-mediated mitophagy

(2018) Wancheng Yu et al.   Journal of Physiological Sciences

Diazoxide reduces local and remote organ damage in a rat model of intestinal ischemia reperfusion

(2018) Saulo Fernandes de Mattos Dourado et al.   JOURNAL OF SURGICAL RESEARCH

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy

(2018) Joaquín G. Cordero et al.   Oxidative Medicine and Cellular Longevity

The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

(2018) Qiongyuan Hu et al.   Cell Death & Disease

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity

(2018) Tingting Fu et al.   Cell Reports

NLRX1 Modulates Immunometabolic Mechanisms Controlling the Host–Gut Microbiota Interactions during Inflammatory Bowel Disease

(2018) Andrew Leber et al.   Frontiers in Immunology

Yap promotes hepatocellular carcinoma metastasis and mobilization via governing cofilin/F-actin/lamellipodium axis by regulation of JNK/Bnip3/SERCA/CaMKII pathways

(2018) Chen Shi et al.   Redox Biology

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

(2017) Geurt Stokman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of melatonin on fatty liver disease: The role of NR4A1/DNA-PKcs/p53 pathway, mitochondrial fission, and mitophagy

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARγ/FUNDC1/mitophagy pathways

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption

(2017) Xiuwen Wu et al.   Scientific Reports

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

(2016) Yao Kuang et al.   Autophagy

Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy

(2016) Mengqi Lv et al.   Protein & Cell

Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research

(2015) Liara M. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

(2015) Brendan A.I. Payne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reperfusion injury and reactive oxygen species: The evolution of a concept

(2015) D. Neil Granger et al.   Redox Biology

Intraluminal Nonbacterial Intestinal Components Control Gut and Lung Injury After Trauma Hemorrhagic Shock

(2014) Jordan E. Fishman et al.   ANNALS OF SURGERY

Exendin-4 protects adipose-derived mesenchymal stem cells from apoptosis induced by hydrogen peroxide through the PI3K/Akt–Sfrp2 pathways

(2014) Hao Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gastro-Intestinal Vascular Emergencies

(2013) Olivier Corcos et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species

(2012) Jae-Sung Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Early Anastomotic Repair in the Rat Intestine is Affected by Transient Preoperative Mesenteric Ischemia

(2009) L. A. E. Posma et al.   JOURNAL OF GASTROINTESTINAL SURGERY

The cell cycle and acute kidney injury

(2009) Peter M. Price et al.   KIDNEY INTERNATIONAL