Article
Biochemistry & Molecular Biology
Rongrong Tan, Jiayang Li, Lu Liu, Qian Wu, Lei Fan, Ningning Ma, Chuwei Yu, Henglei Lu, Xuemei Zhang, Jing Chen, Likun Gong, Jin Ren
Summary: This study discovered that cysteine sulfinic acid decarboxylase (CSAD) expression significantly decreased in non-alcoholic fatty liver disease (NAFLD) patients, which was confirmed in multiple NAFLD mouse models. The overexpression of CSAD in the liver of high-fat diet-fed mice alleviated NAFLD-associated pathologies and increased the expression of fatty acid beta-oxidation genes. CSAD was also found to improve mitochondrial injury. These findings suggest that CSAD has the potential to become a new therapeutic target for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Dennis Freuer, Christa Meisinger, Jakob Linseisen
Summary: Using a two-sample bidirectional Mendelian randomization approach in European populations, it was found that a low relative proportion of carbohydrates and a high proportion of fat in the diet are causally related to higher BMI and WC. Genetically predicted carbohydrate intake was negatively associated with BMI and WC, while fat intake was positively associated with both anthropometric measures.
CLINICAL NUTRITION
(2021)
Article
Food Science & Technology
Panying Xiang, Yushi Du, Guanyu Chen, Yihui Mao, Shuangshuang Li, Qing Li, Yuting Yang, Xueyu Li, Dongliang Wang
Summary: In this study, it is shown that a dietary achievable dose of PCA attenuates high-fat diet-induced adiposity by enhancing fatty acid oxidation without activating adipose thermogenesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jun Sugama, Yusuke Moritoh, Hiroaki Yashiro, Kazue Tsuchimori, Masanori Watanabe
Summary: SCO-792, an enteropeptidase inhibitor, shows therapeutic effects on obesity and diabetes in mice. This study demonstrates that the alteration of gut microbiota composition, modulation of bacterial metabolites, and regulation of IgA in the colon contribute to the therapeutic effects of SCO-792 in obesity.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
A. J. Crean, S. Afrin, H. Niranjan, T. J. Pulpitel, G. Ahmad, A. M. Senior, T. Freire, F. Mackay, M. A. Nobrega, R. Barres, S. J. Simpson, T. Pini
Summary: Dietary factors have an influence on male reproductive function, and the Nutritional Geometry framework was used to study the effects of macronutrient balance on reproductive traits in male mice. The study found that different dietary compositions have varying effects on morphological, testicular, and sperm traits. Interestingly, dietary fat was found to have a positive influence on sperm motility and antioxidant capacity. Body adiposity, on the other hand, was not significantly correlated with any of the reproductive traits measured.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Adam Lepczynski, Malgorzata Ozgo, Katarzyna Michalek, Alicja Dratwa-Chalupnik, Marta Grabowska, Agnieszka Herosimczyk, Kamila P. Liput, Ewa Polawska, Andrzej Kram, Mariusz Pierzchala
Summary: The study found that different high-fat diets had an impact on the structure and protein expression of the murine heart, with SFA-rich diets leading to severe cardiac hypertrophy and fibrosis, while diets rich in n-3 PUFA resulted in less pronounced changes.
Article
Biochemistry & Molecular Biology
Qiong Wang, Xingguo Wang
Summary: A low intake ratio of linoleic acid/a-linolenic acid (LA/ALA) reduces the risk of obesity and metabolic syndrome. In this study, a high-fat diet with a low LA/ALA ratio (HFD+H3L6) significantly decreased the liver index, as well as levels of triacylglycerols and LDL-C in obese mice. The diet also improved the antioxidant status and reduced inflammation in the liver. Moreover, it altered gene expression related to fatty acid synthesis and regulation, increasing the levels of omega-3 fatty acids. These findings highlight the importance of optimizing dietary fat intake for lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Laurence Daoust, Beatrice S-Y Choi, Anne-Laure Agrinier, Thibault V. Varin, Adia Ouellette, Patricia L. Mitchell, Nolwenn Samson, Genevieve Pilon, Emile Levy, Yves Desjardins, Mathieu Laplante, Fernando F. Anhe, Vanessa P. Houde, Andre Marette
Summary: This study investigates the impact of housing conditions on the metabolic outcomes of germ-free (GF) mice after receiving faecal microbiota transplantation (FMT). The results reveal that the housing environment strongly influences gut microbiota composition and function, leading to distinctive phenotypes in recipient mice.
Article
Nutrition & Dietetics
Malgorzata Mizgier, Grazyna Jarzabek-Bielecka, Natalia Wendland, Elzbieta Jodlowska-Siewert, Marcin Nowicki, Alicja Brozek, Witold Kedzia, Dorota Formanowicz, Justyna Opydo-Szymaczek
Summary: The study found associations between different nutrient intakes and inflammation and oxidative stress in PCOS females. Decreased plant protein intake and low carbohydrate intake may increase inflammation and oxidative stress, while cholesterol intake may increase inflammation levels.
Article
Multidisciplinary Sciences
Huda Al Hourani, Buthaina Alkhatib, Islam Al-Shami, Amin N. Olaimat, Murad Al-Holy, Narmeen Jamal Al-Awwad, Mahmoud Abughoush, Nada A. Saleh, Dima AlHalaika, Omar Alboqai, Ayoub Al-Jawaldeh
Summary: Jordan has not conducted a nutrition survey before to determine nutrient and energy intakes. A recent study aimed to investigate the energy and macronutrient consumption of the Jordanian population. Through a cross-sectional food consumption study, 2145 males and females aged 8 to 85 years old were assessed using two non-consecutive 24-hour dietary recalls. The study found that there is a need to take action in all age groups to rectify the deviation of energy and macronutrient intakes from the recommended dietary allowances.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Elena Makarova, Anastasia Dubinina, Elena Denisova, Antonina Kazantseva
Summary: Maternal diet and obesity (MO) can affect taste preferences and increase susceptibility to obesity in offspring. However, the impact of MO itself on these influences is not well understood. This study examined the influence of MO on food choice and obesity in offspring when mothers consumed a standard diet (SD). The findings suggest that when obese mothers consume a balanced diet, MO does not affect food choice and the development of diet-induced obesity in offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gaofeng Yuan, Meijuan Tan, Xiaoe Chen
Summary: This study found that supplementation with PUA can partially improve obesity and liver steatosis induced by HFD in mice by regulating gut microbiota composition.
Article
Cell Biology
Ariane Maria Zanesco, Natalia F. Mendes, Daiane F. Engel, Rodrigo S. Gaspar, Davi Sidarta-Oliveira, Jose Donato, Licio A. Velloso
Summary: This study provides the first evidence for the involvement of CREB in the abnormal regulation of the hypothalamic Pomc endopeptidase system in experimental obesity.
Article
Biochemistry & Molecular Biology
Xuelei Zhang, Zhenping Hou, Xu Tian, Duanqin Wu, Qiuzhong Dai
Summary: This study found that dietary supplementation of epsilon-polylysine improved the immunity of mice and had an impact on gut microbiota and host nutrient metabolism. Epsilon-polylysine reduced body weight and affected the presence of certain types of intestinal microorganisms, while also regulating the metabolism of energy, nitrogen, amino acids, lipids, carbohydrates, glycans, cofactors, and vitamins.
Article
Nutrition & Dietetics
Hye Rim Kim, Eunsol Seo, Seyeon Oh, MinYeong Seo, Kyunghee Byun, Byung-Yong Kim
Summary: This study demonstrates that multi-strain probiotic treatment can alleviate obesity induced by high-carbohydrate diet, modulating the expression of genes related to fat composition, fat metabolism, and thermogenesis. It also improves the levels of obesity-related hormones and reverses the Firmicutes/Bacteroidetes ratio in the gut microbiota.
Article
Biochemistry & Molecular Biology
Yui Iwagaki, Saeko Sugawara, Yasuhisa Huruya, Miki Sato, Qiming Wu, Shuang E, Kazushi Yamamoto, Tsuyoshi Tsuduki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2018)
Article
Chemistry, Applied
Saeko Sugawara, Mamoru Kushida, Yui Iwagaki, Masaki Asano, Kazushi Yamamoto, Yasutake Tomata, Ichiro Tsuji, Tsuyoshi Tsuduki
JOURNAL OF OLEO SCIENCE
(2018)
Article
Nutrition & Dietetics
Masaki Asano, Yui Iwagaki, Saeko Sugawara, Mamoru Kushida, Ran Okouchi, Kazushi Yamamoto, Tsuyoshi Tsuduki
Article
Nutrition & Dietetics
Haruna Ishikawa, Xiaoxu Guo, Saeko Sugawara, Yui Iwagaki, Kazushi Yamamoto, Ai Konno, Mika Nishiuchi, Tsuyoshi Tsuduki
Article
Geriatrics & Gerontology
Qiming Wu, E. Shuang, Kazushi Yamamoto, Tsuyoshi Tsuduki
Article
Biochemistry & Molecular Biology
Miki Igarashi, Kazuhide Watanabe, Tsuyoshi Tsuduki, Ikuo Kimura, Naoto Kubota
Article
Biochemistry & Molecular Biology
Nami Tomonaga, Tsuyoshi Tsuduki, Yuki Manabe, Tatsuya Sugawara
JOURNAL OF LIPID RESEARCH
(2019)
Article
Nutrition & Dietetics
Ran Okouchi, E. Shuang, Kazushi Yamamoto, Toshikuni Ota, Kentarou Seki, Mayumi Imai, Ryuki Ota, Yuta Asayama, Ayaka Nakashima, Kengo Suzuki, Tsuyoshi Tsuduki
Article
Nutrition & Dietetics
Saho Abe, Shu Zhang, Yasutake Tomata, Tsuyoshi Tsuduki, Yumi Sugawara, Ichiro Tsuji
CLINICAL NUTRITION
(2020)
Article
Biochemistry & Molecular Biology
Mamoru Kushida, Saeko Sugawara, Masaki Asano, Kazushi Yamamoto, Shinji Fukuda, Tsuyoshi Tsuduki
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Nutrition & Dietetics
Ran Okouchi, Yuto Sakanoi, Tsuyoshi Tsuduki
Article
Multidisciplinary Sciences
Naoki Saji, Shumpei Niida, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Kenji Toba, Takashi Sakurai
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Masaki Asano, Mamoru Kushida, Kazushi Yamamoto, Yasutake Tomata, Ichiro Tsuji, Tsuyoshi Tsuduki
Article
Neurosciences
Naoki Saji, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Shumpei Niida, Kenji Toba, Takashi Sakurai
Summary: Recent studies have shown an association between the gut microbiome and cerebral small vessel disease (SVD). Higher total SVD scores were associated with cognitive decline and behavioral and psychological symptoms. Specific enterotypes and faecal metabolites were also found to be related to cognitive decline and brain SVD.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Hao Zheng, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, Shinya Toyokuni
Summary: The study demonstrates the use of HNEJ-1 antibody to detect ferroptosis in various tissues and developmental stages, showing age-dependent increase and iron accumulation in ferroptosis. Additionally, ferroptosis was found to impact aging mice and embryonic erythropoiesis.