Article
Endocrinology & Metabolism
Genki Kobayashi, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study investigated the association between LDL cholesterol, HDL cholesterol, and LDL/HDL ratio and the incidence of diabetes, and identified the cut-off values for incident diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Engineering, Chemical
Fangyuan Zhang, Brittany Macshane, Ryan Searcy, Zuyi Huang
Summary: Cholesterol is a vital component of eukaryotic cell membranes and serves as a precursor for other molecules in the body. Maintaining cholesterol homeostasis is crucial for human health, as high cholesterol increases the risk of heart disease. Mathematical models can be used to study the best approaches to reducing overall cholesterol levels, providing insights into suitable drug targeting reactions or processes.
Article
Oncology
Sven H. Loosen, Karel Kostev, Mark Luedde, Tom Luedde, Christoph Roderburg
Summary: Our study found that patients with elevated total cholesterol levels had a significantly lower probability of cancer, while patients with decreased HDL serum levels had a higher risk of cancer. There was no impact of LDL and triglycerides on cancer risk.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Changyu Lv, Wencui Zhang, Xia Tan, Xianping Shang, Mihnea-Alexandru Gaman, Hany Salem, Ahmed Abu-Zaid, Xiaohong Wang
Summary: Tibolone treatment decreases total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels, with a significant reduction in low-density lipoprotein cholesterol observed when administered for <= 26 weeks. The decrease in triglyceride and total cholesterol concentrations is more pronounced in patients with a BMI >= 25 kg/m(2).
PHARMACOLOGICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Vittoria Carmela Danese, Jessica Pepe, Federica Ferrone, Luciano Colangelo, Viviana De Martino, Luciano Nieddu, Giancarlo Ferrazza, Enrico Panzini, Roberto Pascone, Frank Blocki, Salvatore Minisola, Cristiana Cipriani
Summary: The study investigates the relationship between bone, glucose, and lipid metabolism. Hypovitaminosis D leads to worsening lipid profiles through PTH, while higher PTH levels are associated with elevated glucose and LDL-C levels.
Article
Cell Biology
Maks Mihalj, Paul Philipp Heinisch, Markus Huber, Joerg C. Schefold, Alexander Hartmann, Michael Walter, Elisabeth Steinhagen-Thiessen, Juerg Schmidli, Frank Stueber, Lorenz Raeber, Markus M. Luedi
Summary: Cardiac surgery causes a significant sudden drop in key plasma lipid levels, with LDL-C, TC, and HDL-C showing a protective effect against postoperative stroke. This effect is most pronounced during the operation and persists at 24 hours after surgery.
Review
Biochemistry & Molecular Biology
Amirhossein Sahebkar, Zahra Heidari, Zahra Kiani, Masoumeh Atefi, Azadeh Zareie, Mehrnaz Shojaei, Gholamreza Askari, Prashant Kesharwani, Mohammad Bagherniya
Summary: This meta-analysis evaluated the effects of the DASH diet on lipid profiles based on clinical controlled trials. The results showed that following the DASH diet significantly reduced serum triglycerides and low-density lipoprotein cholesterol levels, but had no significant effect on serum total cholesterol and high-density lipoprotein cholesterol levels. Therefore, the DASH diet can be considered as a strategy for the prevention and complementary management of dyslipidemia.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Giovanna Revilla, Lidia Cedo, Mireia Tondo, Antonio Moral, Jose Ignacio Perez, Rosa Corcoy, Enrique Lerma, Victoria Fuste, T. Srivinasa Reddy, Francisco Blanco-Vaca, Eugenia Mato, Joan Carles Escola
Summary: Cholesterol is crucial for various functions in endocrine-related cells, including hormone and steroid production. While LDL-cholesterol and HDL-cholesterol were not consistently associated with endocrine-related cancer risk, LDL receptor plays a critical role in endocrine-related tumor cells by enhancing circulating LDL-C uptake.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Environmental Sciences
Eleni Papadopoulou, Alina Nicolescu, Line S. Haug, Trine Hus, Calin Deleanu, Hubert Dirven, Birgitte Lindeman
Summary: This study explores the association between serum PFAS concentrations and lipoprotein subclasses. After adjusting for confounders, the adjusted models found positive associations between several PFASs and cholesterol concentrations in large to medium sized HDL and medium sized LDL particles. Significant associations were observed between certain PFASs and cholesterol in large to medium LDL particle sizes among women. The study also found that most PFASs tended to be associated with a reduction in VLDL particle number and VLDL triglyceride.
ENVIRONMENTAL POLLUTION
(2022)
Article
Clinical Neurology
Zhirong Yang, Duncan Edwards, Stephen Burgess, Carol Brayne, Jonathan Mant
Summary: This study investigated the potential associations between blood LDL-C, HDL-C, and triglycerides and post-stroke dementia. The results showed that higher LDL-C levels were associated with an increased risk of dementia, while lower triglyceride levels were associated with a decreased risk. There was no association between HDL-C levels and dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Ioannis Liampas, Konstantinos S. Mylonas, Alexandros Brotis, Panagiotis Dervenis, Vasileios Siokas, Alexios-Fotios A. Mentis, Metaxia Dastamani, Athina-Maria Aloizou, Zisis Tsouris, Paraskevi Aslanidou, Christos Bakoyiannis, Efthimios Dardiotis
Summary: The study aimed to determine the differences in serum lipid concentrations between migraine patients and healthy controls. Results showed higher levels of LDL-C, TC, and TG in migraine patients compared to healthy controls, but no significant difference in HDL-C. Adjusting for confounding factors may affect the measured values.
Article
Oncology
Jun Wang, Jinke Zhuge, Dongxu Feng, Bo Zhang, Jianying Xu, Dongkang Zhao, Zhewei Fei, Xia Huang, Wenjie Shi
Summary: This study investigated the causal link between circulating lipids and biliary tract cancer (BtC) using genetic information. The results suggested that LDL and TRG might play a role in the development of BtC. Replication studies with larger sample sizes are needed.
Review
Geriatrics & Gerontology
Sara Abdulrahman Alomar, Mihnea-Alexandru Gaman, Kousalya Prabahar, Omar Ahnaf Arafah, Ftoon Almarshood, Saeed Baradwan, Saud Abdullah Saud Aboudi, Mohammed Abuzaid, Abdullah A. M. A. Almubarki, Osama Alomar, Ismail A. Al-Badawi, Hany Salem, Ahmed Abu-Zaid
Summary: Tamoxifen can alter the lipid profile in females, particularly by decreasing total cholesterol, LDL-C, and HDL-C. Tamoxifen can further reduce total cholesterol and LDL-C if the dose of administration is greater than or equal to 20 mg/day, the treatment duration is less than or equal to 52 weeks, and if it is prescribed in subjects with dyslipidemia.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Genetics & Heredity
Ana Catarina Alves, Beatriz Miranda, Oana Moldovan, Raquel Espirito Santo, Raquel Gouveia Silva, Sandra Soares Cardoso, Luisa Diogo, Monica Seidi, Silvia Sequeira, Mafalda Bourbon
Summary: This study aimed to analyze the association between rare lipid disorders and low LDL or low HDL cholesterol in 7 cases. NGS analysis of genes associated with rare forms of low HDL-c or LDL-c identified genetic variants related to rare lipid disorders. NGS proved to be a fundamental key for genetic testing of rare lipid disorders, helping to find the genetic cause of disease in 6/7 patients with low HDL-c and LDL-c.
FRONTIERS IN GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Vignesh Chidambaram, Lucas Zhou, Jennie Ruelas Castillo, Amudha Kumar, Samuel K. Ayeh, Akshay Gupte, Jann-Yuan Wang, Petros C. Karakousis
Summary: This study found that higher baseline serum cholesterol levels in TB patients were associated with lower risks of all-cause and infection-related mortality, as well as lower levels of inflammatory markers. Body mass index did not modify or confound this association.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Haruna Ishikawa, Xiaoxu Guo, Saeko Sugawara, Yui Iwagaki, Kazushi Yamamoto, Tsuyoshi Tsuduki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Yui Iwagaki, Saeko Sugawara, Yasuhisa Huruya, Miki Sato, Qiming Wu, Shuang E, Kazushi Yamamoto, Tsuyoshi Tsuduki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2018)
Article
Nutrition & Dietetics
Masaki Asano, Yui Iwagaki, Saeko Sugawara, Mamoru Kushida, Ran Okouchi, Kazushi Yamamoto, Tsuyoshi Tsuduki
Article
Nutrition & Dietetics
Haruna Ishikawa, Xiaoxu Guo, Saeko Sugawara, Yui Iwagaki, Kazushi Yamamoto, Ai Konno, Mika Nishiuchi, Tsuyoshi Tsuduki
Article
Geriatrics & Gerontology
Qiming Wu, E. Shuang, Kazushi Yamamoto, Tsuyoshi Tsuduki
Article
Biochemistry & Molecular Biology
Miki Igarashi, Kazuhide Watanabe, Tsuyoshi Tsuduki, Ikuo Kimura, Naoto Kubota
Article
Biochemistry & Molecular Biology
Nami Tomonaga, Tsuyoshi Tsuduki, Yuki Manabe, Tatsuya Sugawara
JOURNAL OF LIPID RESEARCH
(2019)
Article
Nutrition & Dietetics
Ran Okouchi, E. Shuang, Kazushi Yamamoto, Toshikuni Ota, Kentarou Seki, Mayumi Imai, Ryuki Ota, Yuta Asayama, Ayaka Nakashima, Kengo Suzuki, Tsuyoshi Tsuduki
Article
Nutrition & Dietetics
Saho Abe, Shu Zhang, Yasutake Tomata, Tsuyoshi Tsuduki, Yumi Sugawara, Ichiro Tsuji
CLINICAL NUTRITION
(2020)
Article
Biochemistry & Molecular Biology
Mamoru Kushida, Saeko Sugawara, Masaki Asano, Kazushi Yamamoto, Shinji Fukuda, Tsuyoshi Tsuduki
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Nutrition & Dietetics
Ran Okouchi, Yuto Sakanoi, Tsuyoshi Tsuduki
Article
Multidisciplinary Sciences
Naoki Saji, Shumpei Niida, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Kenji Toba, Takashi Sakurai
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Masaki Asano, Mamoru Kushida, Kazushi Yamamoto, Yasutake Tomata, Ichiro Tsuji, Tsuyoshi Tsuduki
Article
Neurosciences
Naoki Saji, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Shumpei Niida, Kenji Toba, Takashi Sakurai
Summary: Recent studies have shown an association between the gut microbiome and cerebral small vessel disease (SVD). Higher total SVD scores were associated with cognitive decline and behavioral and psychological symptoms. Specific enterotypes and faecal metabolites were also found to be related to cognitive decline and brain SVD.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Hao Zheng, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, Shinya Toyokuni
Summary: The study demonstrates the use of HNEJ-1 antibody to detect ferroptosis in various tissues and developmental stages, showing age-dependent increase and iron accumulation in ferroptosis. Additionally, ferroptosis was found to impact aging mice and embryonic erythropoiesis.