Article
Nutrition & Dietetics
Qianqian Xu, Jiangcheng Ye, Mingxiu Gong, Yifan Zhang, Yiwei Yuan, Jin Zhao
Summary: This study aimed to investigate the effects of theabrownin from Wuniuzao dark tea on hepatic lipid metabolism and gut microbiota in mice fed a high-fat diet. The results showed that theabrownin reduced body weight and epididymis fat weight in obese mice and decreased serum triglycerides, cholesterol, and liver enzyme activities. In addition, theabrownin downregulated gene expression related to fatty acid synthesis and lipid production and improved gut microbiota composition.
Article
Agriculture, Multidisciplinary
Xinbo Zhou, Junjie Zhang, Yutong Sun, Jian Shen, Bo Sun, Qingquan Ma
Summary: This study found that glutamine (Gln) has a positive effect on liver steatosis and promotes hepatic homeostasis by improving glucose metabolism and regulating signaling pathways. Obese mice fed with Gln had higher levels of colonic short-chain fatty acids (SCFAs) and lower levels of inflammation factor proteins, and a decrease in the abundance of Firmicutes bacteria was observed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xiaoxian Xie, Mengya Zhang, Lei Sun, Ting Wang, Zhengyan Zhu, Ruonan Shu, Fengchun Wu, Zezhi Li
Summary: This study demonstrates that crocin-I may inhibit obesity by reducing body weight, improving glucose resistance, and alleviating intestinal microbial disorders in HFD-induced obese mice. Crocin-I also helps in restoring SCFAs levels and repairing altered intestinal barrier functioning and inflammation in HFD-induced obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Mengyu Wang, Hui Han, Fan Wan, Ruqing Zhong, Yoon Jung Do, Sang-Ik Oh, Xuemeng Lu, Lei Liu, Bao Yi, Hongfu Zhang
Summary: This study found that DHQ improved lipid dysmetabolism in the body, especially in the liver, and was associated with altered gut flora.
Article
Pharmacology & Pharmacy
Shiyue Luo, Lixiao Zhou, Xuejun Jiang, Yinyin Xia, Lishuang Huang, Run Ling, Shixin Tang, Zhen Zou, Chengzhi Chen, Jingfu Qiu
Summary: Asparagus cochinchinensis, a traditional Chinese medicine, has shown anti-inflammatory properties and the ability to regulate gut microbiota. In a study on obese mice, it was found that the aqueous extract from Asparagus cochinchinensis root (ACE) reduced weight gain and relieved dyslipidemia induced by a high-fat diet. ACE treatment also improved glucose tolerance and insulin resistance, reduced inflammation and lipogenesis in the liver and adipose tissues, and reshaped the gut microbiota of obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Chongyan Zhao, Qingsong Qu, Fang Yang, Zhixun Li, Pengshuo Yang, Lu Han, Xinyuan Shi
Summary: The study found that fermented Panax ginseng by Monascus ruber could alleviate obesity features in rats, decrease serum total cholesterol, LDL cholesterol and IgA levels, increase bile acid excretion in feces, regulate lipid accumulation in hepatocytes, and enhance gut microbiota diversity and abundance.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Yongshou Yang, Rikako Fukui, Huijuan Jia, Hisanori Kato
Summary: The study revealed that dietary supplementation with amaranth significantly reduced triglycerides, total cholesterol, and phospholipids levels in the liver, as well as downregulated the expression of lipogenesis-related genes. Amaranth supplementation also reversed the reduction in gut microbiota diversity and richness induced by a high-fat diet.
Article
Biochemistry & Molecular Biology
Hui Han, Mengyu Wang, Ruqing Zhong, Bao Yi, Martine Schroyen, Hongfu Zhang
Summary: This study investigates the mechanism through which the gut microbiota influences hepatic lipid metabolism in high-fat diet-fed mice. Gut microbiota depletion was found to reduce body weight, fat deposition, glucose levels, cholesterol levels, insulin levels, and leptin levels in these mice. Additionally, it inhibited excessive hepatic lipid accumulation and changed the expression of genes involved in cholesterol and fatty acid metabolism. The abundance of bacteria associated with abnormal metabolism and inflammation was also reduced. There was a strong correlation between the altered gut microbiota abundance and the serum cholesterol level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Guo, Suqin Zhu, Shiyang Li, Yinong Feng, Haohao Wu, Mingyong Zeng
Summary: This study evaluated the anti-obesity effects of two microalgae polysaccharides in obese mice induced by a high-fat diet. The polysaccharides were found to effectively improve obesity-related issues by modulating gut microbiome-mediated host lipid metabolism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Ang Li, Jin Wang, Yuanyifei Wang, Bowei Zhang, Zhenjia Chen, Junling Zhu, Xiaowen Wang, Shuo Wang
Summary: Jinqiao II tartary buckwheat has the potential to alleviate lipid metabolism disorders by reducing hyperlipidemia, fat accumulation, and liver damage, as well as modulating gut microbiota diversity and structure.
Article
Food Science & Technology
Yu Xiong, Feng-Li Zhang, Jing-Ru Li, Pei-Zhi Peng, Bin Liu, Li-Na Zhao
Summary: The study evaluates the effects of Ganoderma lucidum protease hydrolysate (GLPH) on lipid metabolism and intestinal flora in rats fed a high-fat diet. The results show that GLPH reduces triglycerides, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, and aspartate aminotransferase levels, while increasing high-density lipoprotein cholesterol. GLPH also alters the composition of intestinal flora and reduces the abundance of potentially harmful bacteria.
Article
Microbiology
Mei Yang, Yexin Yin, Fang Wang, Haihan Zhang, Xiaokang Ma, Yulong Yin, Bie Tan, Jiashun Chen
Summary: The study demonstrated that Lycium barbarum polysaccharides (LBPs) could alleviate dyslipidemia in obese mice by modulating gut microbiota, reducing adipocyte size and number, and downregulating adipogenesis-related genes. LBPs also increased bacterial diversity, reduced the Firmicutes/Bacteroidetes ratio, and promoted the growth of short-chain fatty acid-producing bacteria, ultimately improving lipid metabolism and gut dysbiosis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Guangying Weng, Jian Huang, Xianyong Ma, Min Song, Yulong Yin, Dun Deng, Jinping Deng
Summary: This study found that B. laterosporus BL1 may be a promising probiotic for preventing obesity by regulating gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Xufei Zhang, Philippe Gerard
Summary: Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality worldwide. The gut microbiota plays a vital role in CVD development and can be influenced by dietary nutrients. The crosstalk between diet and microbiota regulates CVD progression through various mechanisms, including endotoxemia, inflammation, gut barrier dysfunction, and lipid metabolism dysfunction. Microbial metabolites such as trimethylamine-N-oxide (TMAO), secondary bile acids (BAs), short chain fatty acids (SCFAs), and aromatic amino acids (AAAs) contribute to CVD pathogenesis. Dietary interventions targeting the gut microbiota may serve as novel strategies for CVD management.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Food Science & Technology
Yunlong Dong, Hongjie Song, Andrew J. Holmes, Jiabao Yan, Cuiru Ren, Ying Zhang, Wei Zhao, Jianhui Yuan, Yuyang Cheng, David Raubenheimer, Zhenwei Cui
Summary: Growing evidence suggests that ketogenic diets are effective for weight loss, but their unbalanced nutrient composition poses potential health risks. This study aimed to compare the effectiveness of a balanced diet and a ketogenic diet in reversing metabolic syndrome in a mouse model. The results showed that the balanced diet intervention was safer and more effective in ameliorating obesity compared to the ketogenic diet.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Haruna Ishikawa, Xiaoxu Guo, Saeko Sugawara, Yui Iwagaki, Kazushi Yamamoto, Tsuyoshi Tsuduki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2018)
Article
Nutrition & Dietetics
Haruna Ishikawa, Xiaoxu Guo, Saeko Sugawara, Yui Iwagaki, Kazushi Yamamoto, Ai Konno, Mika Nishiuchi, Tsuyoshi Tsuduki
Article
Geriatrics & Gerontology
Qiming Wu, E. Shuang, Kazushi Yamamoto, Tsuyoshi Tsuduki
Article
Biochemistry & Molecular Biology
Miki Igarashi, Kazuhide Watanabe, Tsuyoshi Tsuduki, Ikuo Kimura, Naoto Kubota
Article
Biochemistry & Molecular Biology
Nami Tomonaga, Tsuyoshi Tsuduki, Yuki Manabe, Tatsuya Sugawara
JOURNAL OF LIPID RESEARCH
(2019)
Article
Nutrition & Dietetics
Ran Okouchi, E. Shuang, Kazushi Yamamoto, Toshikuni Ota, Kentarou Seki, Mayumi Imai, Ryuki Ota, Yuta Asayama, Ayaka Nakashima, Kengo Suzuki, Tsuyoshi Tsuduki
Article
Nutrition & Dietetics
Yuto Sakanoi, E. Shuang, Kazushi Yamamoto, Toshikuni Ota, Kentarou Seki, Mayumi Imai, Ryuki Ota, Yuta Asayama, Ayaka Nakashima, Kengo Suzuki, Tsuyoshi Tsuduki
Article
Nutrition & Dietetics
Saho Abe, Shu Zhang, Yasutake Tomata, Tsuyoshi Tsuduki, Yumi Sugawara, Ichiro Tsuji
CLINICAL NUTRITION
(2020)
Article
Biochemistry & Molecular Biology
Mamoru Kushida, Saeko Sugawara, Masaki Asano, Kazushi Yamamoto, Shinji Fukuda, Tsuyoshi Tsuduki
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Nutrition & Dietetics
Ran Okouchi, Yuto Sakanoi, Tsuyoshi Tsuduki
Article
Multidisciplinary Sciences
Naoki Saji, Shumpei Niida, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Kenji Toba, Takashi Sakurai
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Masaki Asano, Mamoru Kushida, Kazushi Yamamoto, Yasutake Tomata, Ichiro Tsuji, Tsuyoshi Tsuduki
Article
Neurosciences
Naoki Saji, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Shumpei Niida, Kenji Toba, Takashi Sakurai
Summary: Recent studies have shown an association between the gut microbiome and cerebral small vessel disease (SVD). Higher total SVD scores were associated with cognitive decline and behavioral and psychological symptoms. Specific enterotypes and faecal metabolites were also found to be related to cognitive decline and brain SVD.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Hao Zheng, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, Shinya Toyokuni
Summary: The study demonstrates the use of HNEJ-1 antibody to detect ferroptosis in various tissues and developmental stages, showing age-dependent increase and iron accumulation in ferroptosis. Additionally, ferroptosis was found to impact aging mice and embryonic erythropoiesis.
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.