Article
Medicine, Research & Experimental
Dailson Nogueira de Souza, Caio Jordao Teixeira, Vanessa Barbosa Veronesi, Gilson Masahiro Murata, Junia Carolina Santos-Silva, Fernanda Ballerini Hecht, Julia Modesto Vicente, Silvana Bordin, Gabriel Forato Anhe
Summary: The male offspring born and breastfed by mothers treated with dexamethasone during pregnancy displayed reduced adiposity, lower circulating triacylglycerol levels in the fed-state, and decreased expression of specific genes in the jejunum. These findings suggest that reduced fat absorption by the jejunum may contribute to the lower adiposity observed in the adult offspring.
Review
Nutrition & Dietetics
Kinga Gawlinska, Dawid Gawlinski, Malgorzata Filip, Edmund Przegalinski
Summary: A maternal high-fat diet during pregnancy and lactation can have irreversible effects on the health of offspring, leading to increased risk of depressive and aggressive behaviors, reduced cognitive development, and symptoms of metabolic syndrome. Epigenetic and molecular studies have shown that maternal nutrition during pregnancy and the suckling period can modify the development of neurotransmitter circuits and other factors important to central nervous system development.
Article
Physiology
Samantha C. Lean, Alejandro A. Candia, Edina Gulacsi, Giselle C. L. Lee, Amanda N. Sferruzzi-Perri
Summary: Diets containing high levels of fat and sugar can have negative effects on pregnancy and newborns, including changes in maternal metabolism, fetal hyperglycemia and hyperinsulinemia, and abnormal development of mammary glands and placenta. These findings highlight the importance of improving dietary habits.
Article
Environmental Sciences
Yongguo Dai, Qi Guo, Kequan Xu, Zheng Gong, Shuaikai Qiu, Xiaoxiang Sun, Jie Liu, Yuxi Wang, Zhixin Yang, Hui Wang, Yu Guo
Summary: This study aimed to investigate the impact of lactational exposure to lactational synthetic oxo determinant (RTS), a common toxic pyrrolizidine alkaloid, on breast milk components and glucose-lipid metabolism in offspring rats. The results revealed a significant reduction in lipids and lipid-like molecules, as well as an accumulation of RTS and its derivatives in breast milk following RTS exposure. Pups exposed to RTS exhibited liver injury, while transaminase leakage in their serum returned to normal levels in adulthood. Furthermore, RTS exposure led to lower serum glucose levels in pups and higher levels in adult male offspring. It also induced hypertriglyceridemia, hepatic steatosis, and decreased glycogen content in both pups and adult offspring. Importantly, the inhibition of the PPARa-FGF21 axis persisted in the offspring's liver after RTS exposure, which may contribute to the metabolic disorders observed in glucose and lipid metabolism in adult offspring.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nutrition & Dietetics
Jia Zheng, Ling Zhang, Ying Gao, Honghua Wu, Junqing Zhang
Summary: A maternal high-fat diet can lead to metabolic disorders and dysbiosis of gut microbiota in offspring after weaning. Although a normal diet after weaning can restore metabolic disorders, the composition of gut microbiota remains different, which may contribute to the susceptibility to obesity and diabetes in the offspring.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Haiyan Pang, Dandan Ling, Yi Cheng, Rubab Akbar, Luyang Jin, Jun Ren, Haiyan Wu, Bin Chen, Yin Zhou, Hong Zhu, Yuzhong Zhou, Hefeng Huang, Jianzhong Sheng
Summary: The study reveals that a high-fat diet during gestation has long-lasting effects on offspring health by leading to DNA demethylation of Ppar alpha, emphasizing the importance of the gestational period in regulating epigenetic mechanisms involved in metabolism.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Filip Jevtovic, Donghai Zheng, Joseph A. Houmard, Polina M. Krassovskaia, Christian A. Lopez, Breanna L. Wisseman, Dylan M. Steen, Nicholas T. Broskey, Christy Isler, Jim DeVente, Xiangming Fang, Linda E. May
Summary: Maternal exercise positively influences offspring MSC metabolism, with resistance exercise having the greatest effect on glucose metabolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Elisa Felix-Soriano, Kristin I. Stanford
Summary: Longer duration of breastfeeding in rodents leads to an adult phenotype that is resistant to diet-induced obesity and has increased brown adipose tissue activity, which is dependent on hypothalamic FGF21 signaling.
Article
Nutrition & Dietetics
Zhaojun Chen, Yunxia Zhu, Ting Wu, Xia Qian, Ye Hu, Wensheng Hu
Summary: This study evaluated the effects of maternal vitamin D deficiency during pregnancy on glycolipid metabolism in offspring at different stages of life, and explored the effectiveness of different dosages of vitamin D supplementation.
FRONTIERS IN NUTRITION
(2023)
Article
Fisheries
Shiwei Xie, YingYing Lin, Tao Wu, Lixia Tian, Jianjun Liang, Beiping Tan
Summary: The study showed that high-fat diets negatively impacted the growth performance of Japanese seabass, leading to lipid accumulation, inflammation, and apoptosis. The suitable dietary lipid level for Japanese seabass should not exceed 129.1 g kg(-1).
AQUACULTURE NUTRITION
(2021)
Article
Nutrition & Dietetics
Xingyue Yang, Wenyan Sun, Qian Wu, Hongyan Lin, Zhixing Lu, Xin Shen, Yongqi Chen, Yan Zhou, Li Huang, Feng Wu, Fei Liu, Dandan Chu
Summary: The use of folic acid during early pregnancy can protect against birth defects, but excess folic acid has been shown to have gender-specific neurodevelopmental toxicity. This study found that female offspring exposed to excess folic acid exhibited increased anxiety, impaired exploratory behavior, motor coordination, and spatial memory. Gene expression analysis revealed specific changes in the brain transcriptome of the female offspring. Certain genes showed apparent gender specificity in response to excess folic acid.
Article
Biochemistry & Molecular Biology
S. V. V. S. Ravi Mangu, Kalpana Patel, Shinde Vijay Sukhdeo, M. R. Savitha, Kunal Sharan
Summary: Maternal high cholesterol levels have a detrimental effect on offspring skeletal development, resulting in low birth weight, smaller body length, delayed skeletal ossification, and low bone mass phenotype. This is attributed to reduced osteoblast activity and increased osteoclast population. Human studies also show a negative correlation between maternal cholesterol levels and cord blood bone formation markers.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Immunology
Caitlin Dreisbach, Hailey Morgan, Caroline Cochran, Adwoa Gyamfi, Wendy Ann Henderson, Stephanie Prescott
Summary: The intestinal microbiota changes during pregnancy and is influenced by maternal obesity. Probiotics and exercise have been found to modulate maternal weight gain and the microbiota. Supplementing Escherichia coli may worsen maternal obesity and contribute to metabolic dysregulation. Offspring exposed to a high fat and high sucrose diet during gestation may experience altered microbiota, metabolism, and behavior, leading to glucose and insulin imbalance, fatty liver, and neurobehavioral deficits. Improving the microbial environment can ameliorate these effects.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Juliana Woyames, Aline Fonseca Pereira Souza, Rosiane Aparecida Miranda, Lorraine Soares Oliveira, Bruna Caetano, Cherley Borba Vieira Andrade, Rodrigo Soares Fortunato, Georgia Correa Atella, Isis Hara Trevenzoli, Luana Lopes Souza, Carmen Cabanelas Pazos-Moura
Summary: Maternal high-fat diet and fructose induced alterations in lipid metabolism and mitochondrial function in skeletal muscle of adult offspring. These changes were modified by maternal diet and fiber type, and were associated with higher skeletal muscle fructose-induced mitochondria injury in adult offspring.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Oliver C. Watkins, Victoria K. B. Cracknell-Hazra, Reshma Appukuttan Pillai, Preben Selvam, Hannah E. J. Yong, Neha Sharma, Sathya Narayanan Patmanathan, Amaury Cazenave-Gassiot, Anne K. Bendt, Keith M. Godfrey, Rohan M. Lewis, Markus R. Wenk, Shiao-Yng Chan
Summary: Maternal hyperglycemia disrupts placental arachidonic acid metabolism, leading to adverse pregnancy outcomes. Myo-inositol shows potential in rectifying glucose-induced perturbations in placental AA metabolism. Further studies are needed to determine the effectiveness of maternal myo-inositol supplementation in reducing AA-associated pregnancy complications.
Article
Biochemistry & Molecular Biology
Haruna Ishikawa, Xiaoxu Guo, Saeko Sugawara, Yui Iwagaki, Kazushi Yamamoto, Tsuyoshi Tsuduki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Yui Iwagaki, Saeko Sugawara, Yasuhisa Huruya, Miki Sato, Qiming Wu, Shuang E, Kazushi Yamamoto, Tsuyoshi Tsuduki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2018)
Article
Nutrition & Dietetics
Masaki Asano, Yui Iwagaki, Saeko Sugawara, Mamoru Kushida, Ran Okouchi, Kazushi Yamamoto, Tsuyoshi Tsuduki
Article
Geriatrics & Gerontology
Qiming Wu, E. Shuang, Kazushi Yamamoto, Tsuyoshi Tsuduki
Article
Biochemistry & Molecular Biology
Miki Igarashi, Kazuhide Watanabe, Tsuyoshi Tsuduki, Ikuo Kimura, Naoto Kubota
Article
Biochemistry & Molecular Biology
Nami Tomonaga, Tsuyoshi Tsuduki, Yuki Manabe, Tatsuya Sugawara
JOURNAL OF LIPID RESEARCH
(2019)
Article
Nutrition & Dietetics
Ran Okouchi, E. Shuang, Kazushi Yamamoto, Toshikuni Ota, Kentarou Seki, Mayumi Imai, Ryuki Ota, Yuta Asayama, Ayaka Nakashima, Kengo Suzuki, Tsuyoshi Tsuduki
Article
Nutrition & Dietetics
Saho Abe, Shu Zhang, Yasutake Tomata, Tsuyoshi Tsuduki, Yumi Sugawara, Ichiro Tsuji
CLINICAL NUTRITION
(2020)
Article
Biochemistry & Molecular Biology
Mamoru Kushida, Saeko Sugawara, Masaki Asano, Kazushi Yamamoto, Shinji Fukuda, Tsuyoshi Tsuduki
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Nutrition & Dietetics
Ran Okouchi, Yuto Sakanoi, Tsuyoshi Tsuduki
Article
Multidisciplinary Sciences
Naoki Saji, Shumpei Niida, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Kenji Toba, Takashi Sakurai
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Masaki Asano, Mamoru Kushida, Kazushi Yamamoto, Yasutake Tomata, Ichiro Tsuji, Tsuyoshi Tsuduki
Article
Neurosciences
Naoki Saji, Kenta Murotani, Takayoshi Hisada, Tsuyoshi Tsuduki, Taiki Sugimoto, Ai Kimura, Shumpei Niida, Kenji Toba, Takashi Sakurai
Summary: Recent studies have shown an association between the gut microbiome and cerebral small vessel disease (SVD). Higher total SVD scores were associated with cognitive decline and behavioral and psychological symptoms. Specific enterotypes and faecal metabolites were also found to be related to cognitive decline and brain SVD.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Hao Zheng, Li Jiang, Tsuyoshi Tsuduki, Marcus Conrad, Shinya Toyokuni
Summary: The study demonstrates the use of HNEJ-1 antibody to detect ferroptosis in various tissues and developmental stages, showing age-dependent increase and iron accumulation in ferroptosis. Additionally, ferroptosis was found to impact aging mice and embryonic erythropoiesis.
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.