Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes

(2022) Bodour S. Rajab et al.   Scientific Reports

Mitochondria as Therapeutic Targets in Heart Failure

(2022) Julia Schwemmlein et al.   Current Heart Failure Reports

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

(2021) Maike Schuldt et al.   Circulation-Heart Failure

Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy

(2021) Daniela Ramaccini et al.   Frontiers in Cell and Developmental Biology

Reduced nicotinamide mononucleotide is a new and potent NAD+precursor in mammalian cells and mice

(2021) Rubén Zapata‐Pérez et al.   FASEB JOURNAL

Time to Think Differently About Sarcomere-Negative Hypertrophic Cardiomyopathy

(2021) Hugh Watkins   CIRCULATION

α-tubulin tail modifications regulate microtubule stability through selective effector recruitment, not changes in intrinsic polymer dynamics

(2021) Jiayi Chen et al.   DEVELOPMENTAL CELL

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy

(2021) Sara Ranjbarvaziri et al.   CIRCULATION

Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

(2020) Christopher N. Toepfer et al.   CIRCULATION

Increased Myocardial Oxygen Consumption Precedes Contractile Dysfunction in Hypertrophic Cardiomyopathy Caused by Pathogenic TNNT2 Gene Variants

(2020) Rahana Y. Parbhudayal et al.   Journal of the American Heart Association

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

(2020) Iacopo Olivotto et al.   LANCET

SLC25A51 is a mammalian mitochondrial NAD+ transporter

(2020) Timothy S. Luongo et al.   NATURE

2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy

(2020) Steve R. Ommen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Unraveling the Genotype‐Phenotype Relationship in Hypertrophic Cardiomyopathy: Obesity‐Related Cardiac Defects as a Major Disease Modifier

(2020) Edgar E. Nollet et al.   Journal of the American Heart Association

How cardiolipin modulates the dynamics of respiratory complex I

(2019) Alexander Jussupow et al.   Science Advances

Ultrastructural Changes of the Right Ventricular Myocytes in Pulmonary Arterial Hypertension

(2019) Nataliia V. Shults et al.   Journal of the American Heart Association

NAD+ metabolism as a target for metabolic health: have we found the silver bullet?

(2019) Niels J. Connell et al.   DIABETOLOGIA

Higher Body Mass Index in Adolescence Predicts Cardiomyopathy Risk in Midlife

(2019) Josefina Robertson et al.   CIRCULATION

Energetic drain driving hypertrophic cardiomyopathy

(2019) Vasco Sequeira et al.   FEBS LETTERS

Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

(2019) Dorsch et al.   Cells

Distinct Subgroups in Hypertrophic Cardiomyopathy in the NHLBI HCM Registry

(2019) Stefan Neubauer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association of Obesity With Adverse Long-term Outcomes in Hypertrophic Cardiomyopathy

(2019) Carlo Fumagalli et al.   JAMA Cardiology

Imbalance of ER and Mitochondria Interactions: Prelude to Cardiac Ageing and Disease?

(2019) Jin Li et al.   Cells

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits

(2018) Paul J.M. Wijnker et al.   ANTIOXIDANTS & REDOX SIGNALING

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy

(2018) Louise L.A.M. Nijenkamp et al.   Circulation-Heart Failure

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

(2018) Christina Yingxian Chen et al.   NATURE MEDICINE

Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis

(2018) Jing Shen et al.   Cell Death & Disease

Effect of Gender and Genetic Mutations on Outcomes in Patients with Hypertrophic Cardiomyopathy

(2018) Hannah G. van Velzen et al.   AMERICAN JOURNAL OF CARDIOLOGY

Clinical Course and Management of Hypertrophic Cardiomyopathy

(2018) Barry J. Maron   NEW ENGLAND JOURNAL OF MEDICINE

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy

(2018) Carolyn Y. Ho et al.   CIRCULATION

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

(2017) Kathleen A. Hershberger et al.   Nature Reviews Nephrology

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

(2017) Zhenjie Xu et al.   SCIENCE

Mitochondrial remodeling: Rearranging, recycling, and reprogramming

(2016) Roberta A. Gottlieb et al.   CELL CALCIUM

Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function

(2016) Mustafa I. Ahmed et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Life-long tailoring of management for patients with hypertrophic cardiomyopathy

(2016) M. Michels et al.   Netherlands Heart Journal

Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

(2016) Sherif F. Nagueh et al.   European Heart Journal-Cardiovascular Imaging

Impaired cardiac mitochondrial oxidative phosphorylation and enhanced mitochondrial oxidative stress in feline hypertrophic cardiomyopathy

(2015) Liselotte B. Christiansen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes

(2015) Kah Yong Goh et al.   CARDIOVASCULAR RESEARCH

Genetic advances in sarcomeric cardiomyopathies: state of the art

(2015) C. Y. Ho et al.   CARDIOVASCULAR RESEARCH

Orphaned mitochondria in heart failure

(2015) Christoph Maack   CARDIOVASCULAR RESEARCH

Rapid changes in NADH and flavin autofluorescence in rat cardiac trabeculae reveal large mitochondrial complex II reserve capacity

(2015) Rob C. I. Wüst et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synergistic role of ADP and Ca2+in diastolic myocardial stiffness

(2015) Vasco Sequeira et al.   JOURNAL OF PHYSIOLOGY-LONDON

New Perspectives on the Prevalence of Hypertrophic Cardiomyopathy

(2015) Christopher Semsarian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture

(2015) Jonathan R Friedman et al.   eLife

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations

(2014) E. Rosalie Witjas-Paalberends et al.   CARDIOVASCULAR RESEARCH

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403QMYH7mutation

(2014) E. Rosalie Witjas-Paalberends et al.   JOURNAL OF PHYSIOLOGY-LONDON

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Three-Dimensional Reconstruction of Cardiac Sarcoplasmic Reticulum Reveals a Continuous Network Linking Transverse-Tubules

(2013) Christian Pinali et al.   CIRCULATION RESEARCH

Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes

(2013) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

(2013) Vasco Sequeira et al.   CIRCULATION RESEARCH

Potential Role of BNIP3 in Cardiac Remodeling, Myocardial Stiffness, and Endoplasmic Reticulum

(2013) Antoine H. Chaanine et al.   Circulation-Heart Failure

Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides

(2013) Dao-Fu Dai et al.   Circulation-Heart Failure

Redox Signaling in Cardiac Physiology and Pathology

(2012) Joseph R. Burgoyne et al.   CIRCULATION RESEARCH

Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension

(2012) Jose Gomez-Arroyo et al.   Circulation-Heart Failure

Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy

(2009) Kazumasa Unno et al.   EUROPEAN HEART JOURNAL