Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

Sex Differences at the Time of Myectomy in Hypertrophic Cardiomyopathy

(2018) Louise L.A.M. Nijenkamp et al.   Circulation-Heart Failure

Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis

(2018) Emily J. Mercer et al.   DEVELOPMENTAL BIOLOGY

Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca2+sensitivity and calpain-induced proteolysis

(2018) Abel Martin-Garrido et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes

(2018) Judith Krysiak et al.   Nature Communications

Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms

(2018) Bogdan Iorga et al.   Frontiers in Physiology

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy

(2018) Judith Montag et al.   Frontiers in Physiology

Microtubules provide a viscoelastic resistance to myocyte motion.

(2018) Matthew Alexander Caporizzo et al.   BIOPHYSICAL JOURNAL

Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy

(2018) R.Y. Parbhudayal et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Untying the knot: protein quality control in inherited cardiomyopathies

(2018) Larissa M. Dorsch et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy

(2018) Carolyn Y. Ho et al.   CIRCULATION

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

(2018) Nicoletta Piroddi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cardiac Disorders and Pathophysiology of Sarcomeric Proteins

(2018) Jolanda van der Velden et al.   PHYSIOLOGICAL REVIEWS

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy

(2017) Judith Montag et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Proteostasis in cardiac health and disease

(2017) Robert H. Henning et al.   Nature Reviews Cardiology

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

(2017) Zhenjie Xu et al.   SCIENCE

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

(2017) James W. McNamara et al.   PLoS One

Value of Genetic Testing for the Prediction of Long-Term Outcome in Patients With Hypertrophic Cardiomyopathy

(2016) Hannah G. van Velzen et al.   AMERICAN JOURNAL OF CARDIOLOGY

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca2+-sensitivity and suppress the modulation of Ca2+-sensitivity by troponin I phosphorylation

(2016) Andrew E. Messer et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy

(2016) Zhan-Peng Huang et al.   CARDIOVASCULAR RESEARCH

Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth

(2016) Zhiqiang Lin et al.   DEVELOPMENTAL CELL

HSP70: therapeutic potential in acute and chronic cardiac disease settings

(2016) Bianca C Bernardo et al.   Future Medicinal Chemistry

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

(2016) P. Robison et al.   SCIENCE

Life-long tailoring of management for patients with hypertrophic cardiomyopathy

(2016) M. Michels et al.   Netherlands Heart Journal

Long-Term Benefit of Myectomy and Anterior Mitral Leaflet Extension in Obstructive Hypertrophic Cardiomyopathy

(2015) Pieter A. Vriesendorp et al.   AMERICAN JOURNAL OF CARDIOLOGY

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Tubulin acetylation: responsible enzymes, biological functions and human diseases

(2015) Lin Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

(2015) Paul J.M. Wijnker et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C

(2015) Ranganath Mamidi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

New Perspectives on the Prevalence of Hypertrophic Cardiomyopathy

(2015) Christopher Semsarian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease

(2015) Vasco Sequeira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window

(2015) Brian D. Polizzotti et al.   Science Translational Medicine

Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice

(2014) Li-qing Weng et al.   ACTA PHARMACOLOGICA SINICA

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations

(2014) E. Rosalie Witjas-Paalberends et al.   CARDIOVASCULAR RESEARCH

Sorting out the trash: the spatial nature of eukaryotic protein quality control

(2014) Emily M Sontag et al.   CURRENT OPINION IN CELL BIOLOGY

Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress

(2014) Rafah Mackeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403QMYH7mutation

(2014) E. Rosalie Witjas-Paalberends et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy

(2014) Patrick M. McLendon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin proteasome system in human cardiomyopathies and heart failure

(2013) Sharlene M. Day   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiovascular autophagy

(2013) Sergio Lavandero et al.   Autophagy

Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts

(2013) Sebastian Kötter et al.   CARDIOVASCULAR RESEARCH

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

(2013) E. Rosalie Witjas-Paalberends et al.   CARDIOVASCULAR RESEARCH

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

(2013) Vasco Sequeira et al.   CIRCULATION RESEARCH

MicroRNA transcriptome profiling in cardiac tissue of hypertrophic cardiomyopathy patients with MYBPC3 mutations

(2013) Diederik W.D. Kuster et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?

(2013) Monte S. Willis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations

(2013) Sabine J. van Dijk et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

PKCα-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis

(2013) Viola Kooij et al.   PLoS One

Cardiomyocyte proliferation contributes to heart growth in young humans

(2013) Mariya Mollova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Myofibrillar Ca2+ sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T

(2012) Christopher R. Bayliss et al.   CARDIOVASCULAR RESEARCH

Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart

(2012) Pingbo Zhang et al.   CIRCULATION

Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension

(2012) Jose Gomez-Arroyo et al.   Circulation-Heart Failure

Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy With Normal Systolic Function

(2011) Sabine J. van Dijk et al.   Circulation-Heart Failure

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

(2011) Eric Villard et al.   EUROPEAN HEART JOURNAL

A 2-D gel reference map of the basic human heart proteome

(2011) Julie Polden et al.   PROTEOMICS

Oxidative Stress Regulates Left Ventricular PDE5 Expression in the Failing Heart

(2010) Zhongbing Lu et al.   CIRCULATION

Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes

(2010) Sek Won Kong et al.   Circulation-Cardiovascular Genetics

HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones

(2010) Michel J. Vos et al.   HUMAN MOLECULAR GENETICS

Involvement of Reductive Stress in the Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Heat Shock Protein 27

(2010) Xia Zhang et al.   HYPERTENSION

Opposing Actions of Extracellular Signal-regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy

(2010) Dominic C. H. Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

(2010) Camille Geeraert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effect of phosphorylated Hsp27 in coronary arteries through actin stabilization

(2010) Aisling A. Robinson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

(2010) Anita C. Hoskins et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy

(2009) Sabine J. van Dijk et al.   CIRCULATION

Evidence From Human Myectomy Samples That MYBPC3 Mutations Cause Hypertrophic Cardiomyopathy Through Haploinsufficiency

(2009) Steven Marston et al.   CIRCULATION RESEARCH

Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy

(2009) Kazumasa Unno et al.   EUROPEAN HEART JOURNAL

The use of phosphate-affinity SDS-PAGE to measure the cardiac troponin I phosphorylation site distribution in human heart muscle

(2009) Andrew E. Messer et al.   Proteomics Clinical Applications

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

Intracellular Protein Aggregation Is a Proximal Trigger of Cardiomyocyte Autophagy

(2008) Paul Tannous et al.   CIRCULATION

Activation of Histone Deacetylase 2 by Inducible Heat Shock Protein 70 in Cardiac Hypertrophy

(2008) Hae Jin Kee et al.   CIRCULATION RESEARCH

αB-Crystallin Suppresses Pressure Overload Cardiac Hypertrophy

(2008) Asangi R.K. Kumarapeli et al.   CIRCULATION RESEARCH

Protein Kinase G Modulates Human Myocardial Passive Stiffness by Phosphorylation of the Titin Springs

(2008) Martina Krüger et al.   CIRCULATION RESEARCH

Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure

(2008) David R. Fermin et al.   Circulation-Cardiovascular Genetics

Protein quality control and degradation in cardiomyocytes

(2008) Xuejun Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY