Imbalance of ER and Mitochondria Interactions: Prelude to Cardiac Ageing and Disease?

Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-AssociatedEndoplasmic Reticulum Membranes in vivo

(2019) Shengnan Wu et al.   CIRCULATION

Sulodexide attenuates endoplasmic reticulum stress induced by myocardial ischaemia/reperfusion by activating the PI3K/Akt pathway

(2019) Danping Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Unfolding the Roles of Mitochondria as Therapeutic Targets for Heart Disease

(2019) Christopher C. Glembotski et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Protein Quality Control in the Endoplasmic Reticulum

(2019) Benjamin M. Adams et al.   PROTEIN JOURNAL

Disturbed Fatty Acid Oxidation, Endoplasmic Reticulum Stress, and Apoptosis in Left Ventricle of Patients With Type 2 Diabetes

(2019) Marko Ljubkovic et al.   DIABETES

Metabolic implications of organelle–mitochondria communication

(2019) Isabel Gordaliza‐Alaguero et al.   EMBO REPORTS

Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation

(2019) Wiersma et al.   Cells

Cost-of-illness studies in heart failure: a systematic review 2004–2016

(2018) Wladimir Lesyuk et al.   BMC Cardiovascular Disorders

Diabetic Cardiomyopathy

(2018) Guanghong Jia et al.   CIRCULATION RESEARCH

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study

(2018) Laila Staerk et al.   BMJ-British Medical Journal

Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study

(2018) Laila Staerk et al.   BMJ-British Medical Journal

ER–Mitochondria Microdomains in Cardiac Ischemia–Reperfusion Injury: A Fresh Perspective

(2018) Hao Zhou et al.   Frontiers in Physiology

Mitochondrial dysfunction caused by m.2336T>C mutation with hypertrophic cardiomyopathy in cybrid cell lines

(2018) Dan Li et al.   MITOCHONDRION

Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence

(2018) Natalie A. Gude et al.   Nature Reviews Cardiology

Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases

(2018) Jin Li et al.   Cells

Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model

(2017) Yu-Juei Hsu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The mitochondrial unfolded protein response: Signaling from the powerhouse

(2017) Mohammed A. Qureshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired mitophagy facilitates mitochondrial damage in Danon disease

(2017) Sherin I. Hashem et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effects of intermittent ladder-climbing exercise training on mitochondrial biogenesis and endoplasmic reticulum stress of the cardiac muscle in obese middle-aged rats

(2017) Kijin Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Proteostasis in cardiac health and disease

(2017) Robert H. Henning et al.   Nature Reviews Cardiology

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metformin attenuates ER stress–induced mitochondrial dysfunction

(2017) Qun Chen et al.   Translational Research

Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation

(2017) Marit Wiersma et al.   Journal of the American Heart Association

High-intensity training reduces intermittent hypoxia-induced ER stress and myocardial infarct size

(2016) Guillaume Bourdier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endoplasmic reticulum (ER) stress triggers Hax1-dependent mitochondrial apoptotic events in cardiac cells

(2016) Eltyeb Abdelwahid et al.   APOPTOSIS

Derailed Proteostasis as a Determinant of Cardiac Aging

(2016) Marit Wiersma et al.   CANADIAN JOURNAL OF CARDIOLOGY

Mitochondrial Metabolism in Aging Heart

(2016) Edward J. Lesnefsky et al.   CIRCULATION RESEARCH

PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice

(2016) Wai San Cheang et al.   DIABETES

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

(2016) Paulus Kirchhof et al.   EUROPACE

2016 European Guidelines on cardiovascular disease prevention in clinical practice

(2016) Massimo F. Piepoli et al.   EUROPEAN HEART JOURNAL

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER–mitochondria Ca2+flux

(2016) Arun Raturi et al.   JOURNAL OF CELL BIOLOGY

Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy

(2016) Gun West et al.   JOURNAL OF CELL SCIENCE

Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats

(2016) Luiz H. M. Bozi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Emerging Network of Mitochondria-Organelle Contacts

(2016) Andrew Murley et al.   MOLECULAR CELL

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease

(2016) I Celardo et al.   Cell Death & Disease

Role of microRNA-130a in myocardial hypoxia/reoxygenation injury

(2016) Hongyan Liu et al.   Experimental and Therapeutic Medicine

Impaired cardiac mitochondrial oxidative phosphorylation and enhanced mitochondrial oxidative stress in feline hypertrophic cardiomyopathy

(2015) Liselotte B. Christiansen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PLEKHM2mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction

(2015) Emad Muhammad et al.   HUMAN MOLECULAR GENETICS

Mitochondrial oxidative stress promotes atrial fibrillation

(2015) Wenjun Xie et al.   Scientific Reports

The ER Stress-Mediated Mitochondrial Apoptotic Pathway and MAPKs Modulate Tachypacing-Induced Apoptosis in HL-1 Atrial Myocytes

(2015) Jiaojiao Shi et al.   PLoS One

Mutations in GTPBP3 Cause a Mitochondrial Translation Defect Associated with Hypertrophic Cardiomyopathy, Lactic Acidosis, and Encephalopathy

(2014) Robert Kopajtich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function

(2014) Helen E. Collins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

(2014) Yongjie Wei et al.   Autophagy

Inherited Cardiomyopathies

(2014) Jeffrey A. Towbin   CIRCULATION JOURNAL

The mitochondrial unfolded protein response in mammalian physiology

(2014) Adrienne Mottis et al.   MAMMALIAN GENOME

Defective sarcoplasmic reticulum–mitochondria calcium exchange in aged mouse myocardium

(2014) C Fernandez-Sanz et al.   Cell Death & Disease

Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes

(2013) Y. Yang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Depressing Mitochondria-Reticulum Interactions Protects Cardiomyocytes From Lethal Hypoxia-Reoxygenation Injury

(2013) Melanie Paillard et al.   CIRCULATION

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

(2013) V. Jovaisaite et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca 2+ Crosstalk

(2012) Yun Chen et al.   CIRCULATION RESEARCH

2012 focused update of the ESC Guidelines for the management of atrial fibrillation

(2012) et al.   EUROPEAN HEART JOURNAL

Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy

(2012) Somasundaram Arumugam et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Loss of Proteostatic Control as a Substrate for Atrial Fibrillation: A Novel Target for Upstream Therapy by Heat Shock Proteins

(2012) Roelien A. M. Meijering et al.   Frontiers in Physiology

Apoptosis in Heart Failure

(2011) Takayuki Fujita et al.   CIRCULATION JOURNAL

Endoplasmic Reticulum Stress and Diabetic Cardiomyopathy

(2011) Jiancheng Xu et al.   Experimental Diabetes Research

Sarcoplasmic reticulum: Structural determinants and protein dynamics

(2011) Vincenzo Sorrentino   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

(2011) R. Bravo et al.   JOURNAL OF CELL SCIENCE

Age As a Risk Factor

(2011) Ravi Dhingra et al.   MEDICAL CLINICS OF NORTH AMERICA

Endoplasmic Reticulum Ca2+ Handling in Excitable Cells in Health and Disease

(2011) G. E. Stutzmann et al.   PHARMACOLOGICAL REVIEWS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and Death

(2011) J. D. Malhotra et al.   Cold Spring Harbor Perspectives in Biology

Oxidative protein folding in the endoplasmic reticulum: Tight links to the mitochondria-associated membrane (MAM)

(2010) Thomas Simmen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Biology of Endoplasmic Reticulum Stress in the Heart

(2010) Jody Groenendyk et al.   CIRCULATION RESEARCH

Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress

(2010) Yi-Bing Ouyang et al.   MITOCHONDRION

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

ER stress in cardiovascular disease

(2009) Tetsuo Minamino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Protein Quality Control by the Proteasome Involves Ubiquitination and the Protease Omi

(2008) Susanne Radke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein quality control and degradation in cardiomyocytes

(2008) Xuejun Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers

(2007) Jonathan E. Nuss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS