Emerging principles in the design of bioengineered made-to-order plant immune receptors

Decoy engineering of the receptor‐like cytoplasmic kinase StPBS1 to defend against virus infection in potato

(2022) Runyao Bai et al.   MOLECULAR PLANT PATHOLOGY

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

New recognition specificity in a plant immune receptor by molecular engineering of its integrated domain

(2022) Stella Cesari et al.   Nature Communications

Prokaryotic innate immunity through pattern recognition of conserved viral proteins

(2022) Linyi Alex Gao et al.   SCIENCE

A wheat resistosome defines common principles of immune receptor channels

(2022) Alexander Förderer et al.   NATURE

A five-transgene cassette confers broad-spectrum resistance to a fungal rust pathogen in wheat

(2021) Ming Luo et al.   NATURE BIOTECHNOLOGY

The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling

(2021) Guozhi Bi et al.   CELL

Parasitic modulation of host development by ubiquitin-independent protein degradation

(2021) Weijie Huang et al.   CELL

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Stepwise artificial evolution of an Sw‐5b immune receptor extends its resistance spectrum against resistance‐breaking isolates of Tomato spotted wilt virus

(2021) Haining Huang et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant “helper” immune receptors are Ca2+-permeable nonselective cation channels

(2021) Pierre Jacob et al.   SCIENCE

RefPlantNLR is a comprehensive collection of experimentally validated plant disease resistance proteins from the NLR family

(2021) Jiorgos Kourelis et al.   PLOS BIOLOGY

Optimizing the PBS1 Decoy System to Confer Resistance to Potyvirus Infection in Arabidopsis and Soybean

(2020) Sarah E. Pottinger et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Ligand-recognizing motifs in plant LysM receptors are major determinants of specificity

(2020) Zoltan Bozsoki et al.   SCIENCE

Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme

(2020) Shoucai Ma et al.   SCIENCE

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

(2020) Raoul Martin et al.   SCIENCE

Engineering a Decoy Substrate in Soybean to Enable Recognition of the Soybean Mosaic Virus NIa Protease

(2019) Matthew Helm et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

An EFR‐Cf‐9 chimera confers enhanced resistance to bacterial pathogens by SOBIR1‐ and BAK1‐dependent recognition of elf18

(2019) Jinbin Wu et al.   MOLECULAR PLANT PATHOLOGY

Reconstitution and structure of a plant NLR resistosome conferring immunity

(2019) Jizong Wang et al.   SCIENCE

Ligand-triggered allosteric ADP release primes a plant NLR complex

(2019) Jizong Wang et al.   SCIENCE

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

Protein engineering expands the effector recognition profile of a rice NLR immune receptor

(2019) Juan Carlos De la Concepcion et al.   eLife

Defended to the Nines: 25 Years of Resistance Gene Cloning Identifies Nine Mechanisms for R Protein Function

(2018) Jiorgos Kourelis et al.   PLANT CELL

Convergent evolution of effector protease recognition by Arabidopsis and barley

(2018) Morgan E Carter et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Stacking three late blight resistance genes from wild species directly into African highland potato varieties confers complete field resistance to local blight races

(2018) Marc Ghislain et al.   PLANT BIOTECHNOLOGY JOURNAL

Specific recognition of two MAX effectors by integrated HMA domains in plant immune receptors involves distinct binding surfaces

(2018) Liwei Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of the Magnaporthe oryzae Effector AVR-Pia by the Decoy Domain of the Rice NLR Immune Receptor RGA5

(2017) Diana Ortiz et al.   PLANT CELL

The Intracellular Immune Receptor Sw-5b Confers Broad-Spectrum Resistance to Tospoviruses through Recognition of a Conserved 21-Amino Acid Viral Effector Epitope

(2017) Min Zhu et al.   PLANT CELL

Variation in theAvrSr35gene determinesSr35resistance against wheat stem rust race Ug99

(2017) Andres Salcedo et al.   SCIENCE

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens

(2016) Panagiotis F. Sarris et al.   BMC BIOLOGY

Integration of decoy domains derived from protein targets of pathogen effectors into plant immune receptors is widespread

(2016) Thomas Kroj et al.   NEW PHYTOLOGIST

Using decoys to expand the recognition specificity of a plant disease resistance protein

(2016) S. H. Kim et al.   SCIENCE

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

Tomato I2 Immune Receptor Can Be Engineered to Confer Partial Resistance to the OomycetePhytophthora infestansin Addition to the FungusFusarium oxysporum

(2015) Artemis Giannakopoulou et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor

(2015) A Maqbool et al.   eLife

Single Amino Acid Mutations in the Potato Immune Receptor R3a Expand Response to Phytophthora Effectors

(2014) María Eugenia Segretin et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

A novel conserved mechanism for plant NLR protein pairs: the “integrated decoy” hypothesis

(2014) Stella Cesari et al.   Frontiers in Plant Science

The Receptor-Like Protein ReMAX of Arabidopsis Detects the Microbe-Associated Molecular Pattern eMax from Xanthomonas

(2013) A. K. Jehle et al.   PLANT CELL

The Rice Resistance Protein Pair RGA4/RGA5 Recognizes the Magnaporthe oryzae Effectors AVR-Pia and AVR1-CO39 by Direct Binding

(2013) S. Cesari et al.   PLANT CELL

Stepwise artificial evolution of a plant disease resistance gene

(2013) C. J. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivoting the Plant Immune System from Dissection to Deployment

(2013) J. L. Dangl et al.   SCIENCE

Identification of Wheat Gene Sr35 That Confers Resistance to Ug99 Stem Rust Race Group

(2013) C. Saintenac et al.   SCIENCE

Activation of a plant nucleotide binding-leucine rich repeat disease resistance protein by a modified self protein

(2012) Brody J. DeYoung et al.   CELLULAR MICROBIOLOGY

A multifaceted genomics approach allows the isolation of the rice Pia-blast resistance gene consisting of two adjacent NBS-LRR protein genes

(2011) Yudai Okuyama et al.   PLANT JOURNAL

Functional stacking of three resistance genes against Phytophthora infestans in potato

(2011) Suxian Zhu et al.   TRANSGENIC RESEARCH

Arabidopsis thalianaPattern Recognition Receptors for Bacterial Elongation Factor Tu and Flagellin Can Be Combined to Form Functional Chimeric Receptors

(2010) Markus Albert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perception of the chitin oligosaccharides contributes to disease resistance to blast fungus Magnaporthe oryzae in rice

(2010) Kyutaro Kishimoto et al.   PLANT JOURNAL

A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides

(2010) A. Brutus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Major Specificity-Determining Amino Acids of the Tomato Cf-9 Disease Resistance Protein Are at Hypervariable Solvent-Exposed Positions in the Central Leucine-Rich Repeats

(2009) Brande B. H. Wulff et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Association Genetics Reveals Three Novel Avirulence Genes from the Rice Blast Fungal Pathogen Magnaporthe oryzae

(2009) K. Yoshida et al.   PLANT CELL

The effector protein Avr2 of the xylem-colonizing fungusFusarium oxysporumactivates the tomato resistance protein I-2 intracellularly

(2009) Petra M. Houterman et al.   PLANT JOURNAL

A single plant resistance gene promoter engineered to recognize multiple TAL effectors from disparate pathogens

(2009) P. Romer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

To Nibble at Plant Resistance Proteins

(2009) F. L. W. Takken et al.   SCIENCE

From Guard to Decoy: A New Model for Perception of Plant Pathogen Effectors

(2008) R. A.L. van der Hoorn et al.   PLANT CELL