Ligand-triggered allosteric ADP release primes a plant NLR complex

Reconstitution and structure of a plant NLR resistosome conferring immunity

(2019) Jizong Wang et al.   SCIENCE

Defended to the Nines: 25 Years of Resistance Gene Cloning Identifies Nine Mechanisms for R Protein Function

(2018) Jiorgos Kourelis et al.   PLANT CELL

Using forward genetics in Nicotiana benthamiana to uncover the immune signaling pathway mediating recognition of the Xanthomonas perforans effector XopJ4

(2018) Alex Schultink et al.   NEW PHYTOLOGIST

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Receptor Kinases in Plant-Pathogen Interactions: More Than Pattern Recognition

(2017) Dingzhong Tang et al.   PLANT CELL

Analysis of the ZAR1 Immune Complex Reveals Determinants for Immunity and Molecular Interactions

(2017) Maël Baudin et al.   PLANT PHYSIOLOGY

Signaling from the plasma-membrane localized plant immune receptor RPM1 requires self-association of the full-length protein

(2017) Farid El Kasmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion

(2017) Jeannette L. Tenthorey et al.   SCIENCE

Near-Atomic Resolution Structure Determination in Over-Focus with Volta Phase Plate by Cs-Corrected Cryo-EM

(2017) Xiao Fan et al.   STRUCTURE

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model

(2016) Maud Bernoux et al.   PLANT CELL

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

(2016) Lachlan W. Casey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

Crystal structure of NOD2 and its implications in human disease

(2016) Sakiko Maekawa et al.   Nature Communications

Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death

(2016) Karl J. Schreiber et al.   PLoS Pathogens

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

The Decoy Substrate of a Pathogen Effector and a Pseudokinase Specify Pathogen-Induced Modified-Self Recognition and Immunity in Plants

(2015) Guoxun Wang et al.   Cell Host & Microbe

Atomic structure of the apoptosome: mechanism of cytochromec- and dATP-mediated activation of Apaf-1

(2015) Mengying Zhou et al.   GENES & DEVELOPMENT

Structure of the apoptosome: mechanistic insights into activation of an initiator caspase fromDrosophila

(2015) Yuxuan Pang et al.   GENES & DEVELOPMENT

Semi-automated selection of cryo-EM particles in RELION-1.3

(2015) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Structural Basis for the Interaction between the Potato Virus X Resistance Protein (Rx) and Its Cofactor Ran GTPase-activating Protein 2 (RanGAP2)

(2013) Wei Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

(2013) A. Marijke Keestra et al.   NATURE

The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a

(2013) J. D. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivoting the Plant Immune System from Dissection to Deployment

(2013) J. L. Dangl et al.   SCIENCE

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Receptor Kinase Signaling Pathways in Plant-Microbe Interactions

(2012) Meritxell Antolín-Llovera et al.   Annual Review of Phytopathology

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

A Xanthomonas uridine 5′-monophosphate transferase inhibits plant immune kinases

(2012) Feng Feng et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

An Autoactive Mutant of the M Flax Rust Resistance Protein Has a Preference for Binding ATP, Whereas Wild-Type M Protein Binds ADP

(2011) Simon J. Williams et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

NLR functions in plant and animal immune systems: so far and yet so close

(2011) Takaki Maekawa et al.   NATURE IMMUNOLOGY

Tracing the origin and evolutionary history of plant nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes

(2011) Jia-Xing Yue et al.   NEW PHYTOLOGIST

Crystal Structure of Full-Length Apaf-1: How the Death Signal Is Relayed in the Mitochondrial Pathway of Apoptosis

(2011) Thomas Frank Reubold et al.   STRUCTURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal Structure of the Caenorhabditis elegans Apoptosome Reveals an Octameric Assembly of CED-4

(2010) Shiqian Qi et al.   CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Coiled-Coil and Nucleotide Binding Domains of the Potato Rx Disease Resistance Protein Function in Pathogen Recognition and Signaling

(2008) G. J. Rairdan et al.   PLANT CELL