Citrullination: A modification important in the pathogenesis of autoimmune diseases

Follicular helper T cells: potential therapeutic targets in rheumatoid arthritis

(2021) Jian Lu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peptidylarginine Deiminase and Alzheimer’s Disease

(2021) Lai Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Characterizing hand and wrist ultrasound pattern in primary Sjögren’s syndrome: a case-control study

(2020) L. K. N. Guedes et al.   CLINICAL RHEUMATOLOGY

The etiology of rheumatoid arthritis

(2020) Hans Ulrich Scherer et al.   JOURNAL OF AUTOIMMUNITY

The Role of Citrullination in Inflammatory Bowel Disease: A Neglected Player in Triggering Inflammation and Fibrosis?

(2020) Gabriele Dragoni et al.   INFLAMMATORY BOWEL DISEASES

PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets

(2020) Ashley M. Curran et al.   Nature Reviews Rheumatology

Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus

(2020) R. Lande et al.   Scientific Reports

Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4

(2020) Theodora-Dorita Tsourouktsoglou et al.   Cell Reports

Neutrophil Extracellular Trap Induced Dendritic Cell Activation Leads to Th1 Polarization in Type 1 Diabetes

(2020) Zuzana Parackova et al.   Frontiers in Immunology

Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses

(2020) Esther Fousert et al.   Cells

Extraintestinal Manifestations in Patients with Inflammatory Bowel Disease: Study Based on the ENEIDA Registry

(2020) Alicia Algaba et al.   DIGESTIVE DISEASES AND SCIENCES

The roles of PAD2 ‐ and PAD4 ‐mediated protein citrullination catalysis in cancers

(2020) Yanbin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis: Biological Effects and Mechanisms of Immunopathogenesis

(2020) Chao-Yi Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)

(2020) Mirre De Bondt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Expression of P2X7 Receptor on Th1, Th17, and Regulatory T Cells in Patients with Systemic Lupus Erythematosus or Rheumatoid Arthritis and Its Correlations with Active Disease

(2020) Mingxuan Li et al.   JOURNAL OF IMMUNOLOGY

Peptidyl arginine deiminase 4 and its potential role in Alzheimer's disease

(2020) Li-ling Wang et al.   MEDICAL HYPOTHESES

Peptidyl arginine deiminases: detection and functional analysis of protein citrullination

(2019) Ronak Tilvawala et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Citrullination in Cancer

(2019) Arseniy E. Yuzhalin   CANCER RESEARCH

Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus

(2019) Saifur Rahman et al.   ANNALS OF THE RHEUMATIC DISEASES

PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination

(2019) Ana Mendanha Falcão et al.   Cell Reports

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis

(2019) Wolfgang Faigle et al.   Frontiers in Immunology

Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages

(2019) Zhujun An et al.   CELL CYCLE

Post-Translational Modifications in NETosis and NETs-Mediated Diseases

(2019) Hamam et al.   Biomolecules

An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders

(2019) Mohammed Alghamdi et al.   Journal of Immunology Research

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

(2018) Hannah M. Knochelmann et al.   Cellular & Molecular Immunology

Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis

(2018) Keiji Hirota et al.   IMMUNITY

Implications of macrophage polarization in autoimmunity

(2018) Samanta C. Funes et al.   IMMUNOLOGY

Primary Sjögren’s Syndrome

(2018) Xavier Mariette et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil extracellular traps in pediatric inflammatory bowel disease

(2018) Yehonatan Gottlieb et al.   PATHOLOGY INTERNATIONAL

Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3

(2018) Dres Damgaard et al.   PLoS One

REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)

(2018) Eleni Frangou et al.   ANNALS OF THE RHEUMATIC DISEASES

The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update

(2018) Marian Rewers et al.   Current Diabetes Reports

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

(2018) Mijke Buitinga et al.   DIABETES

Retraction: Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2018) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoantibodies against citrullinated histone H3 in rheumatoid arthritis and periodontitis patients

(2017) Koen M. J. Janssen et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

(2017) Birgitte Romme Nielsen et al.   JOURNAL OF NEUROIMMUNOLOGY

High-Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4

(2017) Nathalie E. Blachère et al.   Arthritis & Rheumatology

NETosis in Alzheimer’s Disease

(2017) Enrica Caterina Pietronigro et al.   Frontiers in Immunology

Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells

(2016) Hirofumi Masutomi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

(2016) Ursula Fearon et al.   Nature Reviews Rheumatology

Myeloperoxidase anti-neutrophil cytoplasmic antibody affinity is associated with the formation of neutrophil extracellular traps in the kidney and vasculitis activity in myeloperoxidase anti-neutrophil cytoplasmic antibody-associated microscopic polyangii

(2016) Masaharu Yoshida et al.   NEPHROLOGY

Myelin Basic Protein Citrullination in Multiple Sclerosis: A Potential Therapeutic Target for the Pathology

(2016) Lei Yang et al.   NEUROCHEMICAL RESEARCH

Estrogen Metabolism and Risk of Postmenopausal Endometrial and Ovarian Cancer: the B∼FIT Cohort

(2016) Cher M. Dallal et al.   Hormones & Cancer

Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis

(2016) Christina Gerstner et al.   Frontiers in Immunology

NETosis as Source of Autoantigens in Rheumatoid Arthritis

(2016) Elisa Corsiero et al.   Frontiers in Immunology

Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

(2015) Elisa Corsiero et al.   ANNALS OF THE RHEUMATIC DISEASES

Citrullination and autoimmunity

(2015) Guido Valesini et al.   AUTOIMMUNITY REVIEWS

T Cell Epitopes and Post-Translationally Modified Epitopes in Type 1 Diabetes

(2015) John W. McGinty et al.   Current Diabetes Reports

Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation

(2015) Erin Witalison et al.   CURRENT DRUG TARGETS

The role of BAFF in the progression of rheumatoid arthritis

(2015) Fang Wei et al.   CYTOKINE

IgM and IgA Rheumatoid Factors Purified from Rheumatoid Arthritis Sera Boost the Fc Receptor– and Complement-Dependent Effector Functions of the Disease-Specific Anti–Citrullinated Protein Autoantibodies

(2015) Florence Anquetil et al.   JOURNAL OF IMMUNOLOGY

Mass spectrometric identification of citrullination sites and immunohistochemical detection of citrullinated glial fibrillary acidic protein in Alzheimer's disease brains

(2015) Akihito Ishigami et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase–AIF pathway

(2014) Kin Pong U et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With  -Cell Autoimmunity in Patients With Type 1 Diabetes

(2014) Y. Wang et al.   DIABETES

Citrullinated Glucose-Regulated Protein 78 Is an Autoantigen in Type 1 Diabetes

(2014) Dieter Rondas et al.   DIABETES

Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

(2014) Claire M. Bradford et al.   JOURNAL OF NEUROIMMUNOLOGY

Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells

(2014) Pei-Chen Hsu et al.   MOLECULES AND CELLS

Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation

(2014) Rachel Deplus et al.   NUCLEIC ACIDS RESEARCH

Breaking Immunological Tolerance in Systemic Lupus Erythematosus

(2014) Elmar Pieterse et al.   Frontiers in Immunology

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

(2013) Lindsey E. Padgett et al.   Annals of the New York Academy of Sciences

Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps

(2013) Federico Pratesi et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis

(2013) Jing Shi et al.   ANNALS OF THE RHEUMATIC DISEASES

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

Cellular adaptive response of distal renal tubular cells to high-oxalate environment highlights surface alpha-enolase as the enhancer of calcium oxalate monohydrate crystal adhesion

(2013) Rattiyaporn Kanlaya et al.   Journal of Proteomics

Methods for the Detection of Peptidylarginine Deiminase (PAD) Activity and Protein Citrullination

(2013) Sanne M. M. Hensen et al.   MOLECULAR & CELLULAR PROTEOMICS

Serum Levels of Beta2-Microglobulin and Free Light Chains of Immunoglobulins Are Associated with Systemic Disease Activity in Primary Sjögren’s Syndrome. Data at Enrollment in the Prospective ASSESS Cohort

(2013) Jacques-Eric Gottenberg et al.   PLoS One

Immune-Mediated Pore-Forming Pathways Induce Cellular Hypercitrullination and Generate Citrullinated Autoantigens in Rheumatoid Arthritis

(2013) V. Romero et al.   Science Translational Medicine

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Potential role for PADI-mediated histone citrullination in preimplantation development

(2012) Rui Kan et al.   BMC DEVELOPMENTAL BIOLOGY

Citrulline: pharmacological perspectives and its role as an emerging biomarker in future

(2012) Shilpa N. Kaore et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Citrullination under physiological and pathological conditions

(2012) Zsuzsanna Baka et al.   JOINT BONE SPINE

Neuronal PAD4 expression and protein citrullination: Possible role in production of autoantibodies associated with neurodegenerative disease

(2012) Nimish K. Acharya et al.   JOURNAL OF AUTOIMMUNITY

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor   target gene activation

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated levels of fibrinogen-derived endogenous citrullinated peptides in synovial fluid of rheumatoid arthritis patients

(2012) Reinout Raijmakers et al.   ARTHRITIS RESEARCH & THERAPY

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

(2012) Soi Law et al.   ARTHRITIS RESEARCH & THERAPY

Regulation of histone modification and chromatin structure by the p53–PADI4 pathway

(2012) Chizu Tanikawa et al.   Nature Communications

Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis

(2012) Daigo Nakazawa et al.   Frontiers in Immunology

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

(2011) Alexander A. Chumanevich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

(2011) L. Yeo et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoclast activity modulates B-cell development in the bone marrow

(2011) Anna Mansour et al.   CELL RESEARCH

Citrullination of Inhibitor of Growth 4 (ING4) by Peptidylarginine Deminase 4 (PAD4) Disrupts the Interaction between ING4 and p53

(2011) Qin Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2

(2011) Qin Guo et al.   Molecular BioSystems

Anti-CCP antibodies: the past, the present and the future

(2011) Walther J. van Venrooij et al.   Nature Reviews Rheumatology

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Innate immunity and the pathogenesis of type 1 diabetes

(2010) Fabio Arturo Grieco et al.   Seminars in Immunopathology

Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

(2009) L. A. Trouw et al.   ARTHRITIS AND RHEUMATISM

Identification of citrullinated vimentin peptides as T cell epitopes in HLA–DR4–positive patients with rheumatoid arthritis

(2009) Anouk L. Feitsma et al.   ARTHRITIS AND RHEUMATISM

Structural Polymorphism and Multifunctionality of Myelin Basic Protein

(2009) George Harauz et al.   BIOCHEMISTRY

Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1

(2009) T. Orban et al.   DIABETES CARE

Effect of citrullination on the function and conformation of antithrombin

(2009) A. Ordóñez et al.   FEBS Journal

Citrullination of CXCL8 increases this chemokine's ability to mobilize neutrophils into the blood circulation

(2009) T. Loos et al.   HAEMATOLOGICA

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

Apoptosis in the pathogenesis of systemic lupus erythematosus

(2008) LE Munoz et al.   LUPUS

Regulation of p53 Target Gene Expression by Peptidylarginine Deiminase 4

(2008) P. Li et al.   MOLECULAR AND CELLULAR BIOLOGY