The roles of PAD2 ‐ and PAD4 ‐mediated protein citrullination catalysis in cancers

Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines

(2020) Pinar Uysal-Onganer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases

(2020) Marie-Claire Méchin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes

(2020) Taybor W. Parker et al.   Scientific Reports

GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential

(2019) Lois M. Mulligan   Frontiers in Physiology

Peptidylarginine deiminase 4 overexpression resensitizes MCF-7/ADR breast cancer cells to adriamycin via GSK3β/p53 activation

(2019) Qianqian Zhou et al.   Cancer Management and Research

Citrullination in Cancer

(2019) Arseniy E. Yuzhalin   CANCER RESEARCH

Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination

(2019) Santanu Mondal et al.   ACCOUNTS OF CHEMICAL RESEARCH

Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2

(2019) Li Zheng et al.   BIOCHEMISTRY

Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells

(2019) Fujun Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Mining the Human Tissue Proteome for Protein Citrullination

(2018) Chien-Yun Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Peptidylarginine Deiminases Post-Translationally Deiminate Prohibitin and Modulate Extracellular Vesicle Release and MicroRNAs in Glioblastoma Multiforme

(2018) Uchini Kosgodage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription

(2018) Priyanka Sharma et al.   MOLECULAR CELL

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

(2018) A. E. Yuzhalin et al.   Nature Communications

Development of a Selective Inhibitor of Protein Arginine Deiminase 2

(2017) Aaron Muth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

(2017) Yi Qu et al.   Nature Chemical Biology

Investigating the expression, effect and tumorigenic pathway of PADI2 in tumors

(2017) Wei Guo et al.   OncoTargets and Therapy

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling

(2016) Huifeng Wang et al.   Cancer Cell International

Repertaxin, an inhibitor of the chemokine receptors CXCR1 and CXCR2, inhibits malignant behavior of human gastric cancer MKN45 cells in vitro and in vivo and enhances efficacy of 5-fluorouracil

(2016) JUNPU WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Downregulation of the Deiminase PADI2 Is an Early Event in Colorectal Carcinogenesis and Indicates Poor Prognosis

(2016) N. Cantarino et al.   MOLECULAR CANCER RESEARCH

Role of peptidylarginine deiminase type 4 in gastric cancer

(2016) Jiang Xin et al.   Experimental and Therapeutic Medicine

PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-α expression levels

(2016) Yabing Zheng et al.   Oncotarget

Estrogen Metabolism and Risk of Postmenopausal Endometrial and Ovarian Cancer: the B∼FIT Cohort

(2016) Cher M. Dallal et al.   Hormones & Cancer

Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation

(2015) Erin Witalison et al.   CURRENT DRUG TARGETS

Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of Cl-Amidine as Protein Arginine Deiminase Inhibitors

(2015) Venkataraman Subramanian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

The role of peptidylarginine deiminase 4 in ovarian cancer cell tumorigenesis and invasion

(2015) Ying-ying Cui et al.   TUMOR BIOLOGY

Biological relevance of citrullinations: diagnostic, prognostic and therapeutic options

(2014) Natasja S. Gudmann et al.   AUTOIMMUNITY

A novel role for protein arginine deiminase 4 in pluripotency: The emerging role of citrullinated histone H1 in cellular programming

(2014) Daniel J. Slade et al.   BIOESSAYS

PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia

(2014) J. L. McElwee et al.   CANCER RESEARCH

Peptidylarginine deiminase IV promotes the development of chemoresistance through inducing autophagy in hepatocellular carcinoma

(2014) Tingting Fan et al.   Cell and Bioscience

Targeted H3R26 Deimination Specifically Facilitates Estrogen Receptor Binding by Modifying Nucleosome Structure

(2014) Michael J. Guertin et al.   PLoS Genetics

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Identification of PADI2 as a potential breast cancer biomarker and therapeutic target

(2012) John L McElwee et al.   BMC CANCER

Decreased PADI4 mRNA Association with Global Hypomethylation in Hepatocellular Carcinoma During HBV Exposure

(2012) Changsong Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

(2012) M. A. Moscarello et al.   Disease Models & Mechanisms

Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors

(2012) Lin Wang et al.   International Journal of Biological Sciences

Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity

(2012) Yuji Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for Peptidylarginine Deiminase Enzymes in Disease and Female Reproduction

(2012) Sachi HORIBATA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Potential Role for PAD2 in Gene Regulation in Breast Cancer Cells

(2012) Brian D. Cherrington et al.   PLoS One

Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor   target gene activation

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

d-Amino Acid-Based Protein Arginine Deiminase Inhibitors: Synthesis, Pharmacokinetics, and in Cellulo Efficacy

(2012) Kevin L. Bicker et al.   ACS Medicinal Chemistry Letters

Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors

(2011) Justin E. Jones et al.   ACS Chemical Biology

Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression

(2010) P Li et al.   ONCOGENE

Increased PADI4 expression in blood and tissues of patients with malignant tumors

(2009) Xiaotian Chang et al.   BMC CANCER

Functional Connection between Deimination and Deacetylation of Histones

(2009) H. Denis et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes

(2008) Shibo Ying et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Differential estradiol and selective estrogen receptor modulator (SERM) regulation of Keratin 13 gene expression and its underlying mechanism in breast cancer cells

(2008) Shubin Sheng et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY