Myelin Basic Protein Citrullination in Multiple Sclerosis: A Potential Therapeutic Target for the Pathology

Citrullination and autoimmunity

(2015) Guido Valesini et al.   AUTOIMMUNITY REVIEWS

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

(2015) Jorge Ivan Alvarez et al.   NEUROBIOLOGY OF DISEASE

Environmental factors in multiple sclerosis

(2015) Vasiliki Pantazou et al.   PRESSE MEDICALE

Homo-β-amino acid containing MBP(85–99) analogs alleviate experimental autoimmune encephalomyelitis

(2015) Ravi Kant et al.   Scientific Reports

Anti-CCP Antibody Levels Are Not Associated with MS: Results from a Case-Control Study

(2015) Mahmut Alpayci et al.   Biomed Research International

Macrophage subsets and microglia in multiple sclerosis

(2014) Jeroen F. J. Bogie et al.   ACTA NEUROPATHOLOGICA

Immunology of Relapse and Remission in Multiple Sclerosis

(2014) Lawrence Steinman   Annual Review of Immunology

Autophagy and ethanol neurotoxicity

(2014) Jia Luo   Autophagy

Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase–AIF pathway

(2014) Kin Pong U et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Microbial view of central nervous system autoimmunity

(2014) Kerstin Berer et al.   FEBS LETTERS

Structural Insight into the Function of Myelin Basic Protein as a Ligand for Integrin  M 2

(2014) R. Stapulionis et al.   JOURNAL OF IMMUNOLOGY

Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

(2014) Claire M. Bradford et al.   JOURNAL OF NEUROIMMUNOLOGY

Uptake and Presentation of Myelin Basic Protein by Normal Human B Cells

(2014) Marie Klinge Brimnes et al.   PLoS One

Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons

(2013) Shailender Singh et al.   ACTA NEUROPATHOLOGICA

Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis

(2013) Shu Wang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Early axonal damage and progressive myelin pathology define the kinetics of CNS histopathology in a mouse model of multiple sclerosis

(2013) Mascha S. Recks et al.   CLINICAL IMMUNOLOGY

Negative regulation of the peptidylarginine deiminase type IV promoter by NF-κB in human myeloid cells

(2013) Ali K. Abbas et al.   GENE

Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression

(2013) Jason R. Plemel et al.   GLIA

Novel Inhibitors of Protein Arginine Deiminase with Potential Activity in Multiple Sclerosis Animal Model

(2013) Lianhu Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional Roles of the Non-Catalytic Calcium-Binding Sites in the N-Terminal Domain of Human Peptidylarginine Deiminase 4

(2013) Yi-Liang Liu et al.   PLoS One

Peptidylarginine deiminase and protein citrullination in prion diseases

(2013) Byungki Jang et al.   Prion

Peptidylarginine deiminase expression and activity in PAD2 knock-out and PAD4-low mice

(2012) Joyce J.B.C. van Beers et al.   BIOCHIMIE

High dose antigen treatment with a peptide epitope of myelin basic protein modulates T cells in multiple sclerosis patients

(2012) Eric W. Loo et al.   CELLULAR IMMUNOLOGY

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

(2012) M. A. Moscarello et al.   Disease Models & Mechanisms

Neuronal PAD4 expression and protein citrullination: Possible role in production of autoantibodies associated with neurodegenerative disease

(2012) Nimish K. Acharya et al.   JOURNAL OF AUTOIMMUNITY

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

(2012) Jack van Horssen et al.   Journal of Neuroinflammation

Immunodominant fragments of myelin basic protein initiate T cell-dependent pain

(2012) Huaqing Liu et al.   Journal of Neuroinflammation

Myelin Basic Protein Undergoes a Broader Range of Modifications in Mammals than in Lower Vertebrates

(2012) Chunchao Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Environmental factors and their regulation of immunity in multiple sclerosis

(2012) Marcus W. Koch et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Association between pathological and MRI findings in multiple sclerosis

(2012) Massimo Filippi et al.   LANCET NEUROLOGY

Will the real multiple sclerosis please stand up?

(2012) Peter K. Stys et al.   NATURE REVIEWS NEUROSCIENCE

Adhesive Properties and Inflammatory Potential of Citrullinated Myelin Basic Protein Peptide 45–89

(2012) Lali V. Shanshiashvili et al.   NEUROCHEMICAL RESEARCH

Antibodies to MOG in NMO: A seasoned veteran finds a new role

(2012) H. J. Willison et al.   NEUROLOGY

Multiple sclerosis and glutamate excitotoxicity

(2012) Milos Kostic et al.   REVIEWS IN THE NEUROSCIENCES

Preactive Multiple Sclerosis Lesions Offer Novel Clues for Neuroprotective Therapeutic Strategies

(2011) Johannes M. van Noort et al.   CNS & Neurological Disorders-Drug Targets

Multiple sclerosis as a neurodegenerative disease: pathology, mechanisms and therapeutic implications

(2011) Christine Stadelmann   CURRENT OPINION IN NEUROLOGY

Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter

(2011) A. Petzold et al.   EXPERIMENTAL NEUROLOGY

Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms

(2011) Graham S.T. Smith et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood

(2011) Roberta Calabrese et al.   Multiple Sclerosis Journal

The HLA-DP2 protein binds the immunodominant epitope from myelin basic protein, MBP85-99, with high affinity

(2011) B. E. Hansen et al.   TISSUE ANTIGENS

HLA-DR1001 presents “altered-self” peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets

(2010) Eddie A. James et al.   ARTHRITIS AND RHEUMATISM

Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis

(2010) Natalia Wegner et al.   ARTHRITIS AND RHEUMATISM

Myelin basic protein binds microtubules to a membrane surface and to actin filaments in vitro: Effect of phosphorylation and deimination

(2010) Joan M. Boggs et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Solid-State NMR Spectroscopy of Membrane-Associated Myelin Basic Protein—Conformation and Dynamics of an Immunodominant Epitope

(2010) Mumdooh A.M. Ahmed et al.   BIOPHYSICAL JOURNAL

Demyelination versus remyelination in progressive multiple sclerosis

(2010) Stephan Bramow et al.   BRAIN

Importance of research on peptidylarginine deiminase and citrullinated proteins in age-related disease

(2010) Akihito Ishigami et al.   Geriatrics & Gerontology International

Contribution of Myelin Autoantigen Citrullination to T Cell Autoaggression in the Central Nervous System

(2010) A. Carrillo-Vico et al.   JOURNAL OF IMMUNOLOGY

Involvement of peptidylarginine deiminase-mediated post-translational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease

(2009) Byungki Jang et al.   ACTA NEUROPATHOLOGICA

Assessment of Citrullinated Myelin by1H-MR Spectroscopy in Early-Onset Multiple Sclerosis

(2009) K.K. Oguz et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

NMR structural elucidation of myelin basic protein epitope 83–99 implicated in multiple sclerosis

(2009) Zinovia Spyranti et al.   AMINO ACIDS

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

(2009) Jin Young Kim et al.   NATURE NEUROSCIENCE

Multiple sclerosis therapeutics: Unexpected outcomes clouding undisputed successes

(2009) H. Wiendl et al.   NEUROLOGY

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system

(2008) A. A. Musse et al.   Disease Models & Mechanisms

Citrullination of Linear and Cyclic Altered Peptide Ligands from Myelin Basic Protein (MBP87−99) Epitope Elicits a Th1 Polarized Response by T Cells Isolated from Multiple Sclerosis Patients: Implications in Triggering Disease

(2008) George Deraos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities

(2008) Dorothy D Wood et al.   LABORATORY INVESTIGATION

Pathogenesis of Autoimmune Diseases: Antibodies Against Transglutaminase, Peptidylarginine Deiminase and Protein-bound Citrulline in Primary Sjögren’s Syndrome, Multiple Sclerosis and Alzheimer’s Disease

(2008) E. Bodil Roth et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination

(2008) Brian A Kidd et al.   ARTHRITIS RESEARCH & THERAPY