Hepatocyte PPARγ contributes to the progression of non-alcoholic steatohepatitis in male and female obese mice

Hepatocyte-specific loss of PPARγ protects mice from NASH, and increases the therapeutic effects of rosiglitazone in the liver.

(2021) Samuel M. Lee et al.   Cellular and Molecular Gastroenterology and Hepatology

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Rosiglitazone Requires Hepatocyte PPARγ Expression to Promote Steatosis in Male Mice With Diet-Induced Obesity

(2021) Samuel M Lee et al.   ENDOCRINOLOGY

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

(2021) Zhiqiang Pang et al.   NUCLEIC ACIDS RESEARCH

Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice

(2021) Christos Kiourtis et al.   Biology Open

Considerations When Choosing High-Fat, High-Fructose, and High-Cholesterol Diets to Induce Experimental Nonalcoholic Fatty Liver Disease in Laboratory Animal Models

(2021) Sridhar Radhakrishnan et al.   Current Developments in Nutrition

Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high‐fat diet in the genetically diverse Collaborative Cross mouse model

(2020) Aline Conti et al.   FASEB JOURNAL

Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet

(2020) Jose Cordoba-Chacon   PPAR Research

The ALIOS diet in male and female rodents recapitulates the clinical and transcriptomic features of NAFLD and NASH

(2020) Shelley E Harris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

(2020) Henrik H. Hansen et al.   BMC GASTROENTEROLOGY

A comparative analysis of hepatic pathological phenotypes in C57BL/6J and C57BL/6N mouse strains in non-alcoholic steatohepatitis models

(2019) Eri Kawashita et al.   Scientific Reports

Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Non‐alcoholic Fatty Liver Disease in Murine Fast‐food Diet Model

(2019) Bharat Bhushan et al.   HEPATOLOGY

GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network

(2019) Bahram Namjou et al.   BMC Medicine

Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source

(2019) Michelle L Boland et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH)

(2019) Hannah K. Drescher et al.   Frontiers in Physiology

Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Non-alcoholic Fatty Liver Disease

(2019) Xi Jia et al.   Frontiers in Endocrinology

Economic and Clinical Burden of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes in the United States

(2019) Zobair M. Younossi et al.   DIABETES CARE

One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics

(2019) Anna Radziejewska et al.   Lifestyle Genomics

Racial and Ethnic Disparities in Nonalcoholic Fatty Liver Disease Prevalence, Severity, and Outcomes in the United States: A Systematic Review and Meta-analysis

(2018) Nicole E. Rich et al.   Clinical Gastroenterology and Hepatology

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Inflammation is independent of steatosis in a murine model of steatohepatitis

(2017) Wei Wang et al.   HEPATOLOGY

Distinct but complementary contributions of PPAR isotypes to energy homeostasis

(2017) Vanessa Dubois et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Dual Outcomes of Rosiglitazone Treatment on Fatty Liver

(2016) Mingming Gao et al.   AAPS Journal

Hepatic PPARγ Is Not Essential for the Rapid Development of Steatosis After Loss of Hepatic GH Signaling, in Adult Male Mice

(2016) Rhonda D. Kineman et al.   ENDOCRINOLOGY

Association of homocysteine level with biopsy-proven non-alcoholic fatty liver disease: a meta-analysis

(2016) Yining Dai et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice

(2016) Abigail Wolf Greenstein et al.   JOURNAL OF ENDOCRINOLOGY

Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study

(2016) Haijiang Dai et al.   Nutrition Journal

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

(2015) Tommy Pacana et al.   PLoS One

Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice

(2014) Jose Cordoba-Chacon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

(2013) Jason R. Clapper et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells

(2013) Eva Morán-Salvador et al.   JOURNAL OF HEPATOLOGY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients

(2012) Pierre Bedossa et al.   HEPATOLOGY

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

(2012) Yuan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Nuclear receptor PPAR -regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis

(2012) Y. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Up-Regulation of PPAR-γ mRNA Expression in the Liver of Obese Patients: an Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction

(2011) Paulina Pettinelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice

(2010) José Córdoba-Chacón et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C

(2010) Elena Lima-Cabello et al.   CLINICAL SCIENCE

Regulation of homocysteine metabolism and methylation in human and mouse tissues

(2010) Natalie C. Chen et al.   FASEB JOURNAL

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial

(2009) Vlad Ratziu et al.   HEPATOLOGY

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry