Molecular and spatial signatures of mouse brain aging at single-cell resolution

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

(2022) Anthony Fernández-Castañeda et al.   CELL

Cytokine Regulation and Function in T Cells

(2021) Chen Dong   Annual Review of Immunology

Tissue Homeostasis and Inflammation

(2021) Matthew L. Meizlish et al.   Annual Review of Immunology

White matter aging drives microglial diversity

(2021) Shima Safaiyan et al.   NEURON

Immune cell compartmentalization for brain surveillance and protection

(2021) Tommaso Croese et al.   NATURE IMMUNOLOGY

Spatially resolved cell atlas of the mouse primary motor cortex by MERFISH

(2021) Meng Zhang et al.   NATURE

DNA methylation atlas of the mouse brain at single-cell resolution

(2021) Hanqing Liu et al.   NATURE

Decoding molecular and cellular heterogeneity of mouse nucleus accumbens

(2021) Renchao Chen et al.   NATURE NEUROSCIENCE

Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

(2020) John V. Pluvinage et al.   NATURE REVIEWS NEUROSCIENCE

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

(2020) Kalil Alves de Lima et al.   Annual Review of Immunology

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

(2020) Michelle B. Chen et al.   Cell Reports

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

(2020) Wei-Ting Chen et al.   CELL

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Ageing hallmarks exhibit organ-specific temporal signatures

(2020) Nicholas Schaum et al.   NATURE

Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

(2020) Shun-Fat Lau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Cellpose: a generalist algorithm for cellular segmentation

(2020) Carsen Stringer et al.   NATURE METHODS

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

(2019) Bérénice A. Benayoun et al.   GENOME RESEARCH

Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration

(2019) Carla Ribeiro Alvares Batista et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

Single-cell analysis reveals T cell infiltration in old neurogenic niches

(2019) Ben W. Dulken et al.   NATURE

Microglia in Brain Development, Homeostasis, and Neurodegeneration

(2019) Christopher J. Bohlen et al.   Annual Review of Genetics

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression

(2019) Chenglong Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge

(2019) Valentina Murtaj et al.   Frontiers in Aging Neuroscience

Innate Immunity and Neurodegeneration

(2018) Larisa I. Labzin et al.   Annual Review of Medicine

Myelin Plasticity and Nervous System Function

(2018) Michelle Monje   Annual Review of Neuroscience

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

(2018) Ilia D. Vainchtein et al.   SCIENCE

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Microglia and the Brain: Complementary Partners in Development and Disease

(2018) Timothy R. Hammond et al.   Annual Review of Cell and Developmental Biology

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Shared and distinct transcriptomic cell types across neocortical areas

(2018) Bosiljka Tasic et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Massively parallel single-nucleus RNA-seq with DroNc-seq

(2017) Naomi Habib et al.   NATURE METHODS

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing

(2016) Jeffrey R. Moffitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization

(2016) Jeffrey R. Moffitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Neuronal and Vascular Interactions

(2015) Benjamin J. Andreone et al.   Annual Review of Neuroscience

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

Spatially resolved, highly multiplexed RNA profiling in single cells

(2015) K. H. Chen et al.   SCIENCE

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease

(2015) Siddhita D. Mhatre et al.   TRENDS IN NEUROSCIENCES

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Human cognitive aging: Corriger la fortune?

(2014) U. Lindenberger   SCIENCE

Beyond and below the cortex: the contribution of striatal dysfunction to cognition and behaviour in neurodegeneration

(2013) C. O'Callaghan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences

(2011) Adam D. Hart et al.   BRAIN BEHAVIOR AND IMMUNITY

Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review

(2010) H. Seelaar et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

The Aging Brain

(2008) Bruce A. Yankner et al.   Annual Review of Pathology-Mechanisms of Disease

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Aging of cerebral white matter: a review of MRI findings

(2008) Faith M. Gunning-Dixon et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY