Psychological stress in early life as a predisposing factor for the development of chronic pain: Clinical and preclinical evidence and neurobiological mechanisms

Early maternal separation and responsiveness to thermal nociception in rodent offspring: A meta-analytic review

(2016) Liyun Chen et al.   BEHAVIOURAL BRAIN RESEARCH

Childhood Maltreatment and Headache Disorders

(2016) Gretchen E. Tietjen   Current Pain and Headache Reports

The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling

(2016) Maria Maiarù et al.   Science Translational Medicine

Epigenetic programming of the HPA axis: Early life decides

(2016) Chris Murgatroyd et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Long-Term Consequences of Neonatal Injury

(2015) Simon Beggs   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

Maternal separation and early stress cause long-lasting effects on dopaminergic and endocannabinergic systems and alters dendritic morphology in the nucleus accumbens and frontal cortex in rats

(2015) Antonio Romano-López et al.   Developmental Neurobiology

Childhood adversities and adult-onset chronic pain: Results from the World Mental Health Survey, Japan

(2015) A. Stickley et al.   EUROPEAN JOURNAL OF PAIN

Medical Marijuana for Treatment of Chronic Pain and Other Medical and Psychiatric Problems

(2015) Kevin P. Hill   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity

(2015) Aiqin Chen et al.   JOURNAL OF NEUROPHYSIOLOGY

Enhancement of nerve-injury-induced thermal and mechanical hypersensitivity in adult male and female mice following early life stress

(2015) Takashi Nishinaka et al.   LIFE SCIENCES

Early-life stress-induced visceral hypersensitivity and anxiety behavior is reversed by histone deacetylase inhibition

(2015) R. D. Moloney et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Neonatal stress from limited bedding elicits visceral hyperalgesia in adult rats

(2015) Yumei Guo et al.   NEUROREPORT

The maternal deprivation animal model revisited

(2015) Eva M. Marco et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cortisol levels in former preterm children at school age are predicted by neonatal procedural pain-related stress

(2015) Susanne Brummelte et al.   PSYCHONEUROENDOCRINOLOGY

The consequences of pain in early life: injury-induced plasticity in developing pain pathways

(2014) Fred Schwaller et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Consequences of Early-Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations

(2014) S. Maccari et al.   JOURNAL OF NEUROENDOCRINOLOGY

Gender specific effects of neonatal limited nesting on viscerosomatic sensitivity and anxiety-like behavior in adult rats

(2014) D. K. Prusator et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Vaginal hypersensitivity and hypothalamic–pituitary–adrenal axis dysfunction as a result of neonatal maternal separation in female mice

(2014) A.N. Pierce et al.   NEUROSCIENCE

Early maternal separation: a rodent model of depression and a prevailing human condition

(2014) Jerzy Vetulani   Pharmacological Reports

Stress-induced hyperalgesia

(2014) Elaine M. Jennings et al.   PROGRESS IN NEUROBIOLOGY

Early Adverse Life Events and Resting State Neural Networks in Patients With Chronic Abdominal Pain

(2014) Arpana Gupta et al.   PSYCHOSOMATIC MEDICINE

Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age

(2014) Cecil M. Y. Chau et al.   Frontiers in Behavioral Neuroscience

Early-Life Stress, HPA Axis Adaptation, and Mechanisms Contributing to Later Health Outcomes

(2014) Jayanthi Maniam et al.   Frontiers in Endocrinology

Childhood maltreatment and inflammatory markers: a systematic review

(2013) R. Coelho et al.   ACTA PSYCHIATRICA SCANDINAVICA

Stress in the Adult Rat Exacerbates Muscle Pain Induced by Early-Life Stress

(2013) Pedro Alvarez et al.   BIOLOGICAL PSYCHIATRY

The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans

(2013) Etienne Vachon-Presseau et al.   BRAIN

Neonatal stress modulates sickness behavior: Role for proinflammatory cytokines

(2013) Ronit Avitsur et al.   JOURNAL OF NEUROIMMUNOLOGY

Personalized Medicine and Opioid Analgesic Prescribing for Chronic Pain: Opportunities and Challenges

(2013) Stephen Bruehl et al.   JOURNAL OF PAIN

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

(2013) Nikita N. Burke et al.   JOURNAL OF PAIN

Susceptibility to stress-induced visceral sensitivity: a bad legacy for next generations

(2013) V. Théodorou   NEUROGASTROENTEROLOGY AND MOTILITY

Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli

(2013) Kieran Rea et al.   PAIN

Neonatal Pain-Related Stress and NFKBIA Genotype Are Associated with Altered Cortisol Levels in Preterm Boys at School Age

(2013) Ruth E. Grunau et al.   PLoS One

Psychological Trauma and Functional Somatic Syndromes

(2013) Niloofar Afari et al.   PSYCHOSOMATIC MEDICINE

C-reactive protein, early life stress, and wellbeing in healthy adults

(2012) L. L. Carpenter et al.   ACTA PSYCHIATRICA SCANDINAVICA

Procedural pain and brain development in premature newborns

(2012) Susanne Brummelte et al.   ANNALS OF NEUROLOGY

Imipramine reverses alterations in cytokines and BDNF levels induced by maternal deprivation in adult rats

(2012) Gislaine Z. Rus et al.   BEHAVIOURAL BRAIN RESEARCH

Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex

(2012) Leonora E Long et al.   BMC NEUROSCIENCE

Early maternal separation leads to down-regulation of cytokine gene expression

(2012) J. J. Dimatelis et al.   METABOLIC BRAIN DISEASE

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression

(2012) Guillaume Hache et al.   NEUROREPORT

Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stress

(2011) Brent Myers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Association of Childhood Adversities and Early-Onset Mental Disorders With Adult-Onset Chronic Physical Conditions

(2011) Kate M. Scott   ARCHIVES OF GENERAL PSYCHIATRY

Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation

(2011) Lisa C. Loram et al.   BRAIN BEHAVIOR AND IMMUNITY

Nerve growth factor-mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation-induced visceral hypersensitivity in rats

(2011) S.W. Tsang et al.   EUROPEAN JOURNAL OF PAIN

Childhood Abuse and Migraine: Epidemiology, Sex Differences, and Potential Mechanisms

(2011) Gretchen E. Tietjen et al.   HEADACHE

Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats

(2011) Y.-W. Tjong et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat

(2011) Paul G. Green et al.   PAIN

Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism

(2010) Dervla O'Malley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Neonatal Maternal Separation Alters Immune, Endocrine, and Behavioral Responses to Acute Theiler’s Virus Infection in Adult Mice

(2010) M. W. Meagher et al.   BEHAVIOR GENETICS

Maternal separation stress leads to enhanced emotional responses to noxious stimuli in adult rats

(2010) Megan L. Uhelski et al.   BEHAVIOURAL BRAIN RESEARCH

Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus

(2010) Juan Suárez et al.   BRAIN RESEARCH

Long-term impact of neonatal injury in male and female rats: Sex differences, mechanisms and clinical implications

(2010) Jamie L. LaPrairie et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Riluzole Normalizes Early-Life Stress-Induced Visceral Hypersensitivity in Rats: Role of Spinal Glutamate Reuptake Mechanisms

(2010) Romain–Daniel Gosselin et al.   GASTROENTEROLOGY

Sex-dependent maternal deprivation effects on brain monoamine content in adolescent rats

(2010) Ricardo Llorente et al.   NEUROSCIENCE LETTERS

Long-term consequences of early maternal deprivation in serotonergic activity and HPA function in adult rat

(2010) Georgia Rentesi et al.   NEUROSCIENCE LETTERS

Critical Age Windows for Neurodevelopmental Psychiatric Disorders: Evidence from Animal Models

(2010) Eva M. Marco et al.   NEUROTOXICITY RESEARCH

Early life stress paradigms in rodents: potential animal models of depression?

(2010) Mathias V. Schmidt et al.   PSYCHOPHARMACOLOGY

Maternal separation as a model of brain–gut axis dysfunction

(2010) Siobhain M. O’Mahony et al.   PSYCHOPHARMACOLOGY

Interleukin-1 receptor antagonist ameliorates neonatal lipopolysaccharide-induced long-lasting hyperalgesia in the adult rats

(2010) Kuo-Ching Wang et al.   TOXICOLOGY

Divergent effects of amygdala glucocorticoid and mineralocorticoid receptors in the regulation of visceral and somatic pain

(2009) Brent Myers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Early Maternal Deprivation in Rats

(2009) M. De la Fuente et al.   Annals of the New York Academy of Sciences

Neonatal stress modulates sickness behavior

(2009) Ronit Avitsur et al.   BRAIN BEHAVIOR AND IMMUNITY

Neonatal separation stress reduces glial fibrillary acidic protein- and S100β-immunoreactive astrocytes in the rat medial precentral cortex

(2009) Kristina Musholt et al.   Developmental Neurobiology

Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB1and CB2cannabinoid receptors of neonatal rats

(2009) Juan Suárez et al.   HIPPOCAMPUS

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Epigenetic Modulation of mGlu2 Receptors by Histone Deacetylase Inhibitors in the Treatment of Inflammatory Pain

(2009) S. Chiechio et al.   MOLECULAR PHARMACOLOGY

Childhood psychosocial stressors and adult onset arthritis: Broad spectrum risk factors and allostatic load

(2009) Michael Von Korff et al.   PAIN

Adverse events in childhood and chronic widespread pain in adult life: Results from the 1958 British Birth Cohort Study

(2009) Gareth T. Jones et al.   PAIN

Stress-induced analgesia

(2009) Ryan K. Butler et al.   PROGRESS IN NEUROBIOLOGY

Sex-dependent alterations in response to maternal deprivation in rats

(2009) M.P. Viveros et al.   PSYCHONEUROENDOCRINOLOGY

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

(2008) Siobhain M. O'Mahony et al.   BIOLOGICAL PSYCHIATRY

Early Life Stress Enhances the Vulnerability to Chronic Psychosocial Stress and Experimental Colitis in Adult Mice

(2008) Alexa H. Veenema et al.   ENDOCRINOLOGY

Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model

(2008) s. o'mahony et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Dysfunctional nurturing behavior in rat dams with limited access to nesting material: A clinically relevant model for early-life stress

(2008) A.S. Ivy et al.   NEUROSCIENCE

Early life stress as a risk factor for mental health: Role of neurotrophins from rodents to non-human primates

(2008) Francesca Cirulli et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Naturally occurring variations in maternal care modulate the effects of repeated neonatal pain on behavioral sensitivity to thermal pain in the adult offspring

(2008) Claire-Dominique Walker et al.   PAIN

The link between childhood trauma and depression: Insights from HPA axis studies in humans

(2008) Christine Heim et al.   PSYCHONEUROENDOCRINOLOGY

Neonatal tactile stimulation reverses the effect of neonatal isolation on open-field and anxiety-like behavior, and pain sensitivity in male and female adult Sprague–Dawley rats

(2007) A. Imanaka et al.   BEHAVIOURAL BRAIN RESEARCH

Altered Regulation of Gene and Protein Expression of Hypothalamic-Pituitary-Adrenal Axis Components in an Immature Rat Model of Chronic Stress

(2003) S. Avishai-Eliner et al.   JOURNAL OF NEUROENDOCRINOLOGY