The Consequences of Early-Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations

Immune stress in late pregnant rats decreases length of gestation and fecundity, and alters later cognitive and affective behaviour of surviving pre-adolescent offspring

(2016) Jason J. Paris et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Sex differences in prenatally programmed anxiety behaviour in rats: Differential corticotropin-releasing hormone receptor mRNA expression in the amygdaloid complex

(2016) Paula J. Brunton et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Is Oxytocin a Maternal-Foetal Signalling Molecule at Birth? Implications for Development

(2014) W. M. Kenkel et al.   JOURNAL OF NEUROENDOCRINOLOGY

Effects of Adverse Early-Life Events on Aggression and Anti-Social Behaviours in Animals and Humans

(2014) J. Haller et al.   JOURNAL OF NEUROENDOCRINOLOGY

Paternal Influences on Offspring Development: Behavioural and Epigenetic Pathways

(2014) K. Braun et al.   JOURNAL OF NEUROENDOCRINOLOGY

The Effects of Antidepressant Treatment in Prenatally Stressed Rats Support the Glutamatergic Hypothesis of Stress-Related Disorders

(2014) J. Marrocco et al.   JOURNAL OF NEUROSCIENCE

Glucocorticoid Programming of the Fetal Male Hippocampal Epigenome

(2013) Ariann Crudo et al.   ENDOCRINOLOGY

Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities

(2013) Philippe A. Melas et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Sex-specific effects of prenatal stress on glucose homoeostasis and peripheral metabolism in rats

(2013) Paula J Brunton et al.   JOURNAL OF ENDOCRINOLOGY

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Dysfunctional Astrocytic and Synaptic Regulation of Hypothalamic Glutamatergic Transmission in a Mouse Model of Early-Life Adversity: Relevance to Neurosteroids and Programming of the Stress Response

(2013) B. G. Gunn et al.   JOURNAL OF NEUROSCIENCE

Gestational Hypoxia Induces Sex-Differential Methylation of Crhr1 Linked to Anxiety-like Behavior

(2013) Xi Wang et al.   MOLECULAR NEUROBIOLOGY

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development

(2013) C. L. Howerton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder

(2013) D. Mehta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring

(2013) Paula J Brunton   REPRODUCTION

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics

(2013) Paul J. Lucassen et al.   TRENDS IN NEUROSCIENCES

Maternal Care Influences Hippocampal N-Methyl-D-Aspartate Receptor Function and Dynamic Regulation by Corticosterone in Adulthood

(2012) Rosemary C. Bagot et al.   BIOLOGICAL PSYCHIATRY

The early-life social environment and DNA methylation

(2012) M Szyf   CLINICAL GENETICS

Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing

(2012) F. Mohammad et al.   DEVELOPMENT

Prenatal Synthetic Glucocorticoid Treatment Changes DNA Methylation States in Male Organ Systems: Multigenerational Effects

(2012) Ariann Crudo et al.   ENDOCRINOLOGY

Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1

(2012) Xiao-Dong Wang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats

(2012) Jerome Mairesse et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

O-GlcNAc Transferase Is Involved in Glucocorticoid Receptor-mediated Transrepression

(2012) Min-Dian Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Signature of Maternal Rearing in the Methylome in Rhesus Macaque Prefrontal Cortex and T Cells

(2012) N. Provencal et al.   JOURNAL OF NEUROSCIENCE

Anxiety-Like Behavior of Prenatally Stressed Rats Is Associated with a Selective Reduction of Glutamate Release in the Ventral Hippocampus

(2012) J. Marrocco et al.   JOURNAL OF NEUROSCIENCE

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

(2012) Alma Rodenas-Ruano et al.   NATURE NEUROSCIENCE

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

How do environments talk to genes?

(2012) Moshe Szyf   NATURE NEUROSCIENCE

Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults

(2012) Audrey R. Tyrka et al.   PLoS One

Individual Variations in Maternal Care Early in Life Correlate with Later Life Decision-Making and c-Fos Expression in Prefrontal Subregions of Rats

(2012) Felisa N. van Hasselt et al.   PLoS One

Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus

(2012) M. Suderman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress

(2012) Charlotte Laloux et al.   PSYCHONEUROENDOCRINOLOGY

Impact of early life stress on alcohol consumption and on the short- and long-term responses to alcohol in adolescent female rats

(2011) V. Van Waes et al.   BEHAVIOURAL BRAIN RESEARCH

Paternal Transmission of Stress-Induced Pathologies

(2011) David M. Dietz et al.   BIOLOGICAL PSYCHIATRY

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

The ever-changing brain: Cellular and molecular mechanisms for the effects of stressful experiences

(2011) Bruce S. McEwen   Developmental Neurobiology

Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage

(2011) Gregory A. Dunn et al.   ENDOCRINOLOGY

Exposure to Chronic Pregnancy Stress Reverses Peripartum-Associated Adaptations: Implications for Postpartum Anxiety and Mood Disorders

(2011) Katharina M. Hillerer et al.   ENDOCRINOLOGY

The early life social environment and DNA methylation

(2011) Moshe Szyf   Epigenetics

Adult hippocampal glucocorticoid receptor expression and dentate synaptic plasticity correlate with maternal care received by individuals early in life

(2011) Felisa N. van Hasselt et al.   HIPPOCAMPUS

Associations with early-life socio-economic position in adult DNA methylation

(2011) Nada Borghol et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Differential Effect of Prenatal Stress on the Expression of Cortiocotrophin-Releasing Hormone and its Receptors in the Hypothalamus and Amygdala in Male and Female Rats

(2011) I. Zohar et al.   JOURNAL OF NEUROENDOCRINOLOGY

Maternal Care Received by Individual Pups Correlates with Adult CA1 Dendritic Morphology and Synaptic Plasticity in a Sex-Dependent Manner

(2011) F. N. van Hasselt et al.   JOURNAL OF NEUROENDOCRINOLOGY

Forebrain CRF1 Modulates Early-Life Stress-Programmed Cognitive Deficits

(2011) X.-D. Wang et al.   JOURNAL OF NEUROSCIENCE

Within-litter variation in maternal care received by individual pups correlates with adolescent social play behavior in male rats

(2011) F.N. van Hasselt et al.   PHYSIOLOGY & BEHAVIOR

Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

(2011) Patrick O. McGowan et al.   PLoS One

Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats

(2011) Sara Morley-Fletcher et al.   PSYCHOPHARMACOLOGY

Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos

(2011) A. Inoue et al.   SCIENCE

Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma

(2011) N Perroud et al.   Translational Psychiatry

Presynaptic Glutamatergic Dysfunction in Bipolar Disorder

(2010) Guang Chen et al.   BIOLOGICAL PSYCHIATRY

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

(2010) Tim F. Oberlander et al.   Epigenetics

Prenatal Stress, Glucocorticoids and the Programming of the Brain

(2010) L. A. M. Welberg et al.   JOURNAL OF NEUROENDOCRINOLOGY

Prenatal Social Stress in the Rat Programmes Neuroendocrine and Behavioural Responses to Stress in the Adult Offspring: Sex-Specific Effects

(2010) P. J. Brunton et al.   JOURNAL OF NEUROENDOCRINOLOGY

Severe Early Life Stress Hampers Spatial Learning and Neurogenesis, but Improves Hippocampal Synaptic Plasticity and Emotional Learning under High-Stress Conditions in Adulthood

(2010) C. A. Oomen et al.   JOURNAL OF NEUROSCIENCE

Hippocampal Dysfunction and Cognitive Impairments Provoked by Chronic Early-Life Stress Involve Excessive Activation of CRH Receptors

(2010) A. S. Ivy et al.   JOURNAL OF NEUROSCIENCE

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats

(2010) Charlotte A. Oomen et al.   PSYCHOPHARMACOLOGY

Ethanol Attenuates Spatial Memory Deficits and Increases mGlu1a Receptor Expression in the Hippocampus of Rats Exposed to Prenatal Stress

(2009) Vincent Van Waes et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Reduced Hypothalamo-pituitary-adrenal Axis Stress Responses in Late Pregnancy

(2009) John A. Russell et al.   Annals of the New York Academy of Sciences

Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

(2009) Tania L. Roth et al.   BIOLOGICAL PSYCHIATRY

Maternal High-Fat Diet Promotes Body Length Increases and Insulin Insensitivity in Second-Generation Mice

(2009) Gregory A. Dunn et al.   ENDOCRINOLOGY

Effect of an Acute Maternal Stress on the Fetal Hypothalamo-Pituitary-Adrenal System in Late Gestational Life of the Rat

(2009) Tomi Ohkawa et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: Implications for spatial memory

(2009) Bárbara Aisa et al.   HIPPOCAMPUS

Neuroscience, Molecular Biology, and the Childhood Roots of Health Disparities

(2009) Jack P. Shonkoff et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

(2009) Patrick O McGowan et al.   NATURE NEUROSCIENCE

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus

(2009) Rosemary C. Bagot et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats

(2009) M. Lukas et al.   NEUROPHARMACOLOGY

Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic–pituitary–adrenal axis and induces anxiety-like behavior in adult male rat offspring

(2009) J.-M. Fan et al.   NEUROSCIENCE

Opposite Effects of Early Maternal Deprivation on Neurogenesis in Male versus Female Rats

(2009) Charlotte A. Oomen et al.   PLoS One

Lifelong Impact of Variations in Maternal Care on Dendritic Structure and Function of Cortical Layer 2/3 Pyramidal Neurons in Rat Offspring

(2009) Laura A. Smit-Rigter et al.   PLoS One

Maternal deprivation by early weaning increases corticosterone and decreases hippocampal BDNF and neurogenesis in mice

(2009) Takefumi Kikusui et al.   PSYCHONEUROENDOCRINOLOGY

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Abnormal Glutamatergic Neurotransmission and Neuronal-Glial Interactions in Acute Mania

(2008) Dost Öngür et al.   BIOLOGICAL PSYCHIATRY

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

(2008) Kunal Rai et al.   CELL

A Novel Mouse Model for Acute and Long-Lasting Consequences of Early Life Stress

(2008) Courtney J. Rice et al.   ENDOCRINOLOGY

Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11β-hydroxysteroid dehydrogenase type 2

(2008) P. J. Lucassen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Adaptive Responses of the Maternal Hypothalamic-Pituitary-Adrenal Axis during Pregnancy and Lactation

(2008) P. J. Brunton et al.   JOURNAL OF NEUROENDOCRINOLOGY

Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress

(2008) D. L. Champagne et al.   JOURNAL OF NEUROSCIENCE

Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

(2008) B. R. Mueller et al.   JOURNAL OF NEUROSCIENCE

Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function

(2008) Caroline Bertram et al.   JOURNAL OF PHYSIOLOGY-LONDON

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

The long-term behavioural consequences of prenatal stress

(2008) Marta Weinstock   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Fetal undernutrition induces overexpression of CRH mRNA and CRH protein in hypothalamus and increases CRH and corticosterone in plasma during postnatal life in the rat

(2008) Héctor Núñez et al.   NEUROSCIENCE LETTERS

Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats

(2008) Anna Rita Zuena et al.   PLoS One

Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain

(2008) Patrick O. McGowan et al.   PLoS One

Fundamental aspects of the impact of glucocorticoids on the (immature) brain

(2008) Danielle L. Champagne et al.   Seminars in Fetal & Neonatal Medicine

Epigenetic programming of the stress response in male and female rats by prenatal restraint stress

(2007) Muriel Darnaudéry et al.   BRAIN RESEARCH REVIEWS

Influence of Neonatal Rearing Conditions on Stress-Induced Adrenocorticotropin Responses and Norepinepherine Release in the Hypothalamic Paraventricular Nucleus

(2003) Liu et al.   JOURNAL OF NEUROENDOCRINOLOGY