Maternal separation and early stress cause long-lasting effects on dopaminergic and endocannabinergic systems and alters dendritic morphology in the nucleus accumbens and frontal cortex in rats

Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain

(2015) Antonios Stamatakis et al.   PSYCHONEUROENDOCRINOLOGY

Lentiviral Vector-Mediated Dopamine D3 Receptor Modulation in the Rat Brain Impairs Alcohol Intake and Ethanol-Induced Conditioned Place Preference

(2014) Amine Bahi et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone

(2014) Gian Marco Leggio et al.   NEUROPSYCHOPHARMACOLOGY

Endocannabinoid/GABA interactions in the entopeduncular nucleus modulates alcohol intake in rats

(2013) Mónica Méndez-Díaz et al.   BRAIN RESEARCH BULLETIN

Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications

(2013) Roger G. Pertwee   PROCEEDINGS OF THE NUTRITION SOCIETY

The Endocannabinoid System and the Brain

(2012) Raphael Mechoulam et al.   Annual Review of Psychology

Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus

(2012) Eva Martisova et al.   NEUROPHARMACOLOGY

Maternal separation and proclivity for ethanol intake: A potential role of the endocannabinoid system in rats

(2012) A. Romano-López et al.   NEUROSCIENCE

Predator threat stress promotes long lasting anxiety-like behaviors and modulates synaptophysin and CB1 receptors expression in brain areas associated with PTSD symptoms

(2012) Alline Cristina Campos et al.   NEUROSCIENCE LETTERS

Oleamide restores sleep in adult rats that were subjected to maternal separation

(2012) Nidia M. Reyes Prieto et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Endocannabinoids in nervous system health and disease: the big picture in a nutshell

(2012) S. D. Skaper et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Influence of Gene–Environment Interactions on the Development of Alcoholism and Drug Dependence

(2012) Mary-Anne Enoch   Current Psychiatry Reports

Neuropeptides as mediators of the early-life impact on the brain; implications for alcohol use disorders

(2012) Ingrid Nylander et al.   Frontiers in Molecular Neuroscience

AKT Signaling Pathway in the Nucleus Accumbens Mediates Excessive Alcohol Drinking Behaviors

(2011) Jérémie Neasta et al.   BIOLOGICAL PSYCHIATRY

Ethanol-induced effects on the dopamine and serotonin systems in adult Wistar rats are dependent on early-life experiences

(2011) Sadia Oreland et al.   BRAIN RESEARCH

Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion

(2011) M. López-Gallardo et al.   NEUROSCIENCE

Cannabinoid receptor expression and phosphorylation are differentially regulated between male and female cerebellum and brain stem after repeated stress: Implication for PTSD and drug abuse

(2011) Guoqiang Xing et al.   NEUROSCIENCE LETTERS

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

The endocannabinoid system modulates the valence of the emotion associated to food ingestion

(2010) Mónica Méndez-Díaz et al.   ADDICTION BIOLOGY

Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders

(2010) J. Neasta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From endocannabinoid profiling to ‘endocannabinoid therapeutics’

(2009) Alessia Ligresti et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB1and CB2cannabinoid receptors of neonatal rats

(2009) Juan Suárez et al.   HIPPOCAMPUS

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Voluntary alcohol consumption alters stress-induced changes in dopamine-2 receptor binding in Wistar–Kyoto rat brain

(2009) Irene Yaroslavsky et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The effect of cannabinoid CB1 receptor antagonist rimonabant (SR-141716) on ethanol drinking in high-preferring rats

(2008) Wanda Dyr et al.   ALCOHOL

Genetic and Environmental Influences on Alcohol, Caffeine, Cannabis, and Nicotine Use From Early Adolescence to Middle Adulthood

(2008) Kenneth S. Kendler et al.   ARCHIVES OF GENERAL PSYCHIATRY

Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: A possible role for the endocannabinoid system

(2008) Ricardo Llorente et al.   Developmental Neurobiology

Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat

(2008) Maria Pascual et al.   JOURNAL OF NEUROCHEMISTRY

Conditional cannabinoid receptor type 1 mutants reveal neuron subpopulation-specific effects on behavioral and neuroendocrine stress responses

(2008) Michel A. Steiner et al.   PSYCHONEUROENDOCRINOLOGY

Maternal separation stress in male mice: long-term increases in alcohol intake

(2008) Fábio C. Cruz et al.   PSYCHOPHARMACOLOGY

Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus

(2007) E Soria-Gómez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex

(2007) Jason J. Radley et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Chronic Stress that Impairs Reactivity in Rats Also Decreases Dopaminergic Transmission in the Nucleus Accumbens: A Microdialysis Study

(2003) Carla Gambarana et al.   JOURNAL OF NEUROCHEMISTRY