Article
Psychology, Developmental
Bo Ou-Yang, Yue Hu, Xin-Yuan Fei, Sha-Te Cheng, Ying Hang, Chen Yang, Liang Cheng
Summary: Adverse early life experiences, such as maternal separation, can significantly impair cognitive flexibility in rodent offspring, but the relationship is not consistent and may be moderated by variations in experimental procedures.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Francisco Sindermann Lumertz, Erika Kestering-Ferreira, Rodrigo Orso, Kerstin Camile Creutzberg, Saulo Gantes Tractenberg, Bruna Alvim Stocchero, Thiago Wendt Viola, Rodrigo Grassi-Oliveira
Summary: Exposure to early life stress (ELS) can lead to long-lasting neurobiological and behavioral impairments, and is associated with changes in the immune system and neuroinflammatory state. This study on rodents found that ELS exposure increases pro-inflammatory cytokines, while anti-inflammatory cytokines remain unchanged. The effects of ELS are most prominent in the hippocampus of adult animals, but are less observed in aged animals.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Psychiatry
Mariana Rocha, Daniel Wang, Victor Avila-Quintero, Michael H. Bloch, Arie Kaffman
Summary: This study conducted a meta-analysis on the effects of different rodent models of early life stress (ELS) on hippocampal-dependent memory, revealing similar cognitive deficits in tasks relying on the dorsal hippocampus for LBN and MS, while handling improved performance. In the CFC task, all three ELS paradigms showed reduced freezing with moderate effect sizes. Further investigation is needed to explore the potential differences in the dorsal hippocampus caused by handling compared to MS and LBN.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Jiapeng Huang, Chunlan Yang, Kehong Zhao, Ziqi Zhao, Yin Chen, Tingting Wang, Yun Qu
Summary: TENS shows promise in ameliorating neuropathic pain, but caution should be taken when interpreting the results, as the studies reviewed were conducted on animals. Further high-quality research is needed to validate the efficacy of TENS.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Multidisciplinary Sciences
Heike Schuler, Valeria Bonapersona, Marian Joels, R. Angela Sarabdjitsingh
Summary: Early-life adversity causes long-lasting changes to the brain that increase vulnerability to psychopathologies later in life. Immediate-early genes (IEGs) can serve as markers for these alterations, connecting activity-regulated transcription to long-term effects on brain structure and function. A systematic review of 39 pre-clinical studies in rodents found that ELA (alteration of maternal care) affected IEG expression, particularly in relation to cFos expression after acute stressors and at rest. These findings suggest that ELA creates a phenotype similar to naive, acutely stressed animals.
Review
Behavioral Sciences
Pascaline Langlois, Anaick Perrochon, Romain David, Pierre Rainville, Chantal Wood, Audrey Vanhaudenhuyse, Benjamin Pageaux, Amine Ounajim, Martin Lavalliere, Ursula Debarnot, Carlos Luque-Moreno, Manuel Roulaud, Martin Simoneau, Lisa Goudman, Maarten Moens, Philippe Rigoard, Maxime Billot
Summary: This systematic review and meta-analysis found that hypnosis treatment can effectively reduce pain intensity and pain interference in patients with chronic musculoskeletal and neuropathic pain. A minimum of 8 sessions of hypnosis treatment is recommended for better outcomes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Davide Previtali, Alberto Mameli, Stefano Zaffagnini, Paolo Marchettini, Christian Candrian, Giuseppe Filardo
Summary: The present study aimed to analyze existing evidence on pain sensitisation in tendinopathies. Results showed that tendinopathies are characterized by pain sensitisation, with conflicting results for different types of tendinopathies. Patients' characteristics were found to significantly influence the results of pain sensitisation.
Review
Clinical Neurology
Jeremy R. Chang, Siu-Ngor Fu, Xun Li, Shirley X. Li, Xiaoyue Wang, Zhixing Zhou, Sabina M. Pinto, Dino Samartzis, Jaro Karppinen, Arnold YL. Wong
Summary: This systematic review and meta-analysis examined the effects of different experimental sleep deprivation paradigms on pain outcomes. The results showed that total sleep deprivation significantly reduced pain threshold and tolerance in healthy individuals, while partial sleep deprivation increased spontaneous pain intensity. Sleep fragmentation was found to increase peripheral and central sensitization in healthy individuals. The effects of sleep deprivation on pain outcomes in individuals with chronic pain were uncertain. Further research is needed to better understand these relationships.
SLEEP MEDICINE REVIEWS
(2022)
Review
Behavioral Sciences
Zhenjiang Li, Libo Zhang, Yuxuan Zeng, Qing Zhao, Li Hu
Summary: This study conducted a systematic review and meta-analysis to characterize the temporal, frequential, and spatial characteristics of pain-induced gamma-band oscillations (GBOs) and summarize their functional significance. The study found that GBO heterogeneity was mainly related to pain types, with higher frequency GBOs (-66 Hz) elicited by phasic pain and lower frequency GBOs (-55 Hz) associated with tonic and chronic pains. Positive correlations between GBO magnitudes and pain intensity were observed in healthy participants. Additionally, the characteristics and functions of GBOs appeared to be phylogenetically conserved across humans and rodents.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Multidisciplinary Sciences
Matthias Zunhammer, Tamas Spisak, Tor D. Wager, Ulrike Bingel
Summary: Placebo analgesia influences pain-related activity in multiple brain areas, with activity increases mainly in frontoparietal regions, and reductions in regions belonging to ventral attention and somatomotor networks. The findings suggest that the neural mechanisms of placebo analgesia are complex and involve multiple cerebral mechanisms that differ across studies.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Lingwen Jin, Jing Zhang, Xin Yang, Hui Rong
Summary: This meta-analysis aimed to evaluate the effects of maternal voice on neonatal procedural pain and provide insights for clinical pain care of neonates. The results showed that maternal voice can reduce pain score and heart rate, and improve comfort level and blood oxygen saturation during and after procedures in neonates.
Review
Behavioral Sciences
Annabel Vetterlein, Merlin Monzel, Martin Reuter
Summary: The COMT gene has been considered as the pain sensitivity gene for almost two decades, but there is inconsistent evidence in the literature. Our meta-analyses of 31 samples and 4631 participants showed small effects of rs4680 on pain thresholds in fibromyalgia, headache, and chronic pain conditions. The effects of rs4680 were found in pain patients when affected body sites were assessed. No effects were found for other investigated SNPs. These results support the theory that rs4680 may only impact behavioral measures of pain under certain conditions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Anesthesiology
Dominika J. Burek, Nicolas Massaly, Hye Jean Yoon, Michelle Doering, Jose A. Moron
Summary: This study conducted a systematic review and meta-analysis to investigate the effects of complete Freund adjuvant-induced inflammation on various behaviors in rodents. The results showed that complete Freund adjuvant modestly decreased exploratory behavior, increased passive stress coping, and decreased preference for sucrose and naturally rewarding activity.
Review
Behavioral Sciences
Samuel Lopes, Flavia de Lima Osorio
Summary: Oxytocin (OXT) plays a neuromodulatory role in emotion, stress, and anxiety. This study aims to identify the effects of intranasal OXT on the self-perception of clinical and experimental pain among human subjects through a systematic literature review and meta-analysis.
HORMONES AND BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Xiaoying Meng, Binghao Bao, Guangxin Yue
Summary: This bibliometric study analyzed the impact of maternal separation on brain development and psychopathological adaptation, identified key research topics and trends, and provided a scientific reference for future studies in this field.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)