Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 906, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2021.174274
Keywords
Prostate cancer; TRAMP; Metastasis; Transcription factors; Diosgenin; Protein kinases
Categories
Funding
- National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2021R1I1A2060024]
- National Medical Research Council of Singapore [NRNMRPR18101]
- Singapore Ministry of Education [MOE-T2EP30120-0016]
- International Scientific Partnership Program ISPP at King Saud University [0091]
- MOE Tier 1 grant
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Research has shown that diosgenin can inhibit the activation of NF-Kappa B/STAT3 in prostate cancer cells and suppress tumor progression in in vivo models. This inhibition is achieved through the suppression of protein kinases and reporter gene activity, leading to reduced expression of tumorigenic gene products.
Prostate cancer (PCa) is a common disease among men especially in the old age. The deregulated activation of oncogenic and pro-survival transcription factors has been linked with tumor progression in PCa patients. The consequence of diosgenin treatment on NF-Kappa B/STAT3 activation in PCa cells as well as transgenic mouse model was determined. We also validated the hypothesis of targeting these transcription factors using in silico proteomics simulation model. Diosgenin abrogated NF-Kappa B/STAT3 activation and this action was caused as a result of suppression of protein kinases and reporter gene activity that led to a substantial reduction in the expression of various tumorigenic gene products. In vivo, diosgenin (2% w/w) when mixed in diet and fed to mice abrogated tumor progression in transgenic mice. Diosgenin was also detected in serum and was well absorbed orally. Overall, our data highlights the promising efficacy of diosgenin in PCa therapy.
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