Beta-3 adrenergic receptor overexpression reverses aortic stenosis–induced heart failure and restores balanced mitochondrial dynamics

Coronary blood flow in heart failure: cause, consequence and bystander

(2022) Gerd Heusch   BASIC RESEARCH IN CARDIOLOGY

Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis

(2022) Christine Quast et al.   BASIC RESEARCH IN CARDIOLOGY

Hemodynamic Effects of Cyclic Guanosine Monophosphate-Dependent Signaling Through β3 Adrenoceptor Stimulation in Patients With Advanced Heart Failure: A Randomized Invasive Clinical Trial

(2022) Henning Bundgaard et al.   Circulation-Heart Failure

Multifaceted remodelling of cAMP microdomains driven by different aetiologies of heart failure

(2021) Kirstie A. De Jong et al.   FEBS Journal

Cardiac Hypertrophy Changes Compartmentation of cAMP in Non-Raft Membrane Microdomains

(2021) Nikoleta Pavlaki et al.   Cells

β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

(2020) Sophie Schobesberger et al.   eLife

Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy

(2020) Emilie Dubois‐Deruy et al.   ESC Heart Failure

Papel de los bloqueadores beta en la enfermedad cardiovascular en 2019

(2019) Juan Martínez-Milla et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Abnormalities of Mitochondrial Dynamics in the Failing Heart: Normalization Following Long-Term Therapy with Elamipretide

(2018) Hani N. Sabbah et al.   CARDIOVASCULAR DRUGS AND THERAPY

Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing optic atrophy 1 processing in the failing heart

(2018) Yongzheng Guo et al.   CARDIOVASCULAR RESEARCH

Human β3-Adrenoreceptor is Resistant to Agonist-Induced Desensitization in Renal Epithelial Cells

(2018) Serena Milano et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Metabolic remodeling of substrate utilization during heart failure progression

(2018) Liang Chen et al.   HEART FAILURE REVIEWS

Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity

(2018) Belén Prados et al.   Cell Death & Disease

Cardiac myocyte β3-adrenergic receptors prevent myocardial fibrosis by modulating oxidant stress-dependent paracrine signaling

(2017) Nerea Hermida et al.   EUROPEAN HEART JOURNAL

Cardiac beta3-adrenergic receptors in the clinical arena: the end of the beginning

(2017) Jean-Luc Balligand   EUROPEAN JOURNAL OF HEART FAILURE

Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial

(2017) Jean-Sébastien Hulot et al.   EUROPEAN JOURNAL OF HEART FAILURE

β 1 -Blockade Prevents Post-Ischemic Myocardial Decompensation Via β 3 AR-Dependent Protective Sphingosine-1 Phosphate Signaling

(2017) Alessandro Cannavo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease

(2017) Rick A. Nishimura et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Aerobic exercise protects against pressure overload-induced cardiac dysfunction and hypertrophy via β3-AR-nNOS-NO activation

(2017) Bin Wang et al.   PLoS One

Cardiac salvage by tweaking with beta-3-adrenergic receptors

(2016) Jean-Luc Balligand   CARDIOVASCULAR RESEARCH

The first-in-man randomized trial of a beta3 adrenoceptor agonist in chronic heart failure: the BEAT-HF trial

(2016) Henning Bundgaard et al.   EUROPEAN JOURNAL OF HEART FAILURE

Natural History, Diagnostic Approaches, and Therapeutic Strategies for Patients With Asymptomatic Severe Aortic Stenosis

(2016) Philippe Généreux et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Management strategies and future challenges for aortic valve disease

(2016) Robert O Bonow et al.   LANCET

Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes

(2015) Kah Yong Goh et al.   CARDIOVASCULAR RESEARCH

Population-Wide Trends in Aortic Stenosis Incidence and Outcomes

(2015) R. O. Bonow et al.   CIRCULATION

Exercise Triggers ARVC Phenotype in Mice Expressing a Disease-Causing Mutated Version of Human Plakophilin-2

(2015) Francisco M. Cruz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

β3 adrenergic receptor selective stimulation during ischemia/reperfusion improves cardiac function in translational models through inhibition of mPTP opening in cardiomyocytes

(2014) Jaime García-Prieto et al.   BASIC RESEARCH IN CARDIOLOGY

Nebivolol Protects against Myocardial Infarction Injury via Stimulation of Beta 3-Adrenergic Receptors and Nitric Oxide Signaling

(2014) Zheng Zhang et al.   PLoS One

β3-Adrenoreceptor Stimulation Protects against Myocardial Infarction Injury via eNOS and nNOS Activation

(2014) Xiaolin Niu et al.   PLoS One

Enhanced Expression of β3-Adrenoceptors in Cardiac Myocytes Attenuates Neurohormone-Induced Hypertrophic Remodeling Through Nitric Oxide Synthase

(2013) Catharina Belge et al.   CIRCULATION

Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes

(2013) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Adrenergic Nervous System in Heart Failure

(2013) Anastasios Lymperopoulos et al.   CIRCULATION RESEARCH

Long-Term Effects of AAV1/SERCA2a Gene Transfer in Patients With Severe Heart Failure

(2013) Krisztina Zsebo et al.   CIRCULATION RESEARCH

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Myocardial β2-adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure

(2012) G Rengo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy

(2012) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Cardioprotective Effect of Beta-3 Adrenergic Receptor Agonism

(2012) Xiaolin Niu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Glucose metabolism and cardiac hypertrophy

(2011) S. C. Kolwicz et al.   CARDIOVASCULAR RESEARCH

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of β 3 -Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols

(2011) John W. Calvert et al.   CIRCULATION RESEARCH

Beta3-Adrenoreceptor Stimulation Ameliorates Myocardial Ischemia-Reperfusion Injury Via Endothelial Nitric Oxide Synthase and Neuronal Nitric Oxide Synthase Activation

(2011) Juan P. Aragón et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Beta3-Adrenoceptor Activation Just Says NO to Myocardial Reperfusion Injury⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

(2011) Gerd Heusch   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Nebivolol Exerts Beneficial Effects on Endothelial Function, Early Endothelial Progenitor Cells, Myocardial Neovascularization, and Left Ventricular Dysfunction Early After Myocardial Infarction Beyond Conventional β1-Blockade

(2011) Sajoscha A. Sorrentino et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

(2011) S. T. Pleger et al.   Science Translational Medicine

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

β 3 Adrenergic Stimulation of the Cardiac Na + -K + Pump by Reversal of an Inhibitory Oxidative Modification

(2010) Henning Bundgaard et al.   CIRCULATION

Analysis of Metabolic Remodeling in Compensated Left Ventricular Hypertrophy and Heart Failure

(2010) Takao Kato et al.   Circulation-Heart Failure

Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the β3-adrenoreceptor

(2009) An L. Moens et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

cGMP rescues mitochondrial dysfunction induced by glucose and insulin in myocytes

(2008) Masanori Mitsuishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats

(2008) Pál Pacher et al.   Nature Protocols

Antiarrhythmic effects of beta3-adrenergic receptor stimulation in a canine model of ventricular tachycardia

(2007) Shengmei Zhou et al.   HEART RHYTHM