Multifaceted remodelling of cAMP microdomains driven by different aetiologies of heart failure

Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device – the SERCA-LVAD TRIAL

(2020) A. R. Lyon et al.   GENE THERAPY

Extended‐Release Oral Milrinone for the Treatment of Heart Failure With Preserved Ejection Fraction

(2020) Shane Nanayakkara et al.   Journal of the American Heart Association

Metabolic Inhibition Induces Transient Increase of L-type Ca2+ Current in Human and Rat Cardiac Myocytes

(2019) Rimantas Treinys et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement From the American Heart Association and the Heart Failure Society of America

(2019) Shannon M. Dunlay et al.   CIRCULATION

Beta-blocker use and cardiovascular event risk in patients with heart failure with preserved ejection fraction

(2018) Tetsuro Tsujimoto et al.   Scientific Reports

The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF

(2018) Nazir Savji et al.   JACC-Heart Failure

Arterial Stiffening With Exercise in Patients With Heart Failure and Preserved Ejection Fraction

(2017) Yogesh N.V. Reddy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

G protein-coupled receptor kinase 2 promotes cardiac hypertrophy

(2017) Philipp Schlegel et al.   PLoS One

Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart

(2017) Qin Fu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

(2017) Nicoletta C. Surdo et al.   Nature Communications

Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart FailureNovelty and Significance

(2016) Jose L. Sanchez-Alonso et al.   CIRCULATION RESEARCH

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

(2016) Sherif F. Nagueh et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Sustained βAR Stimulation Mediates Cardiac Insulin Resistance in a PKA-Dependent Manner

(2016) Supachoke Mangmool et al.   MOLECULAR ENDOCRINOLOGY

Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

(2016) Brian W Jones et al.   eLife

Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure

(2016) H. Kirk Hammond et al.   JAMA Cardiology

Changes in T-Tubules and Sarcoplasmic Reticulum in Ventricular Myocytes in Early Cardiac Hypertrophy in a Pressure Overload Rat Model

(2015) Perla Pérez-Treviño et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes

(2015) Qin Fu et al.   CELLULAR SIGNALLING

Microdomain Switch of cGMP-Regulated Phosphodiesterases Leads to ANP-Induced Augmentation of  -Adrenoceptor-Stimulated Contractility in Early Cardiac Hypertrophy

(2015) R. K. Perera et al.   CIRCULATION RESEARCH

The Evolving Impact of G Protein-Coupled Receptor Kinases in Cardiac Health and Disease

(2015) Priscila Y. Sato et al.   PHYSIOLOGICAL REVIEWS

Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses

(2015) James M. Haley et al.   PLoS One

In vivo model with targeted cAMP biosensor reveals changes in receptor–microdomain communication in cardiac disease

(2015) Julia U. Sprenger et al.   Nature Communications

Imaging alterations of cardiomyocyte cAMP microdomains in disease

(2015) Alexander Froese et al.   Frontiers in Pharmacology

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns

(2014) Elisa Lucas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin Inhibits Cardiac Contractility by Inducing a Gi-Biased  2-Adrenergic Signaling in Hearts

(2014) Q. Fu et al.   DIABETES

Compartmentation of cAMP signalling in cardiomyocytes in health and disease

(2013) R. K. Perera et al.   Acta Physiologica

Differential regulation of cardiac excitation–contraction coupling by cAMP phosphodiesterase subtypes

(2013) Delphine Mika et al.   CARDIOVASCULAR RESEARCH

Enhanced Expression of β3-Adrenoceptors in Cardiac Myocytes Attenuates Neurohormone-Induced Hypertrophic Remodeling Through Nitric Oxide Synthase

(2013) Catharina Belge et al.   CIRCULATION

Adenylyl Cyclase Subtype–Specific Compartmentalization

(2013) Valeriy Timofeyev et al.   CIRCULATION RESEARCH

Cardiac Insulin-Resistance and Decreased Mitochondrial Energy Production Precede the Development of Systolic Heart Failure After Pressure-Overload Hypertrophy

(2013) Liyan Zhang et al.   Circulation-Heart Failure

Adenylyl cyclase 6 deletion increases mortality during sustained β-adrenergic receptor stimulation

(2013) Tong Tang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes

(2013) Hind Mehel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data

(2012) Sabine Fredersdorf et al.   Cardiovascular Diabetology

Trends in Patients Hospitalized With Heart Failure and Preserved Left Ventricular Ejection Fraction

(2012) Benjamin A. Steinberg et al.   CIRCULATION

Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart

(2012) Sanja Beca et al.   CIRCULATION RESEARCH

Plasticity of Surface Structures and β 2 -Adrenergic Receptor Localization in Failing Ventricular Cardiomyocytes During Recovery From Heart Failure

(2012) Alexander R. Lyon et al.   Circulation-Heart Failure

G Protein–Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia

(2011) Michele Ciccarelli et al.   CIRCULATION

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2+ Release and Cardiac Contractility, Independently of L-Type Ca 2+ Current

(2011) Sanja Beca et al.   CIRCULATION RESEARCH

Deletion of the Distal C Terminus of CaV1.2 Channels Leads to Loss of β-Adrenergic Regulation and Heart Failurein Vivo

(2011) Ying Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restoration of Defective L-type Ca2+ Current in Cardiac Myocytes of Type 2 Diabetic db/db Mice by Akt and PKC-ι

(2011) Zhongju Lu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Adenylyl Cyclase 6 Improves Calcium Uptake and Left Ventricular Function in Aged Hearts

(2011) Tong Tang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ca 2+ Cycling and New Therapeutic Approaches for Heart Failure

(2010) Anne-Marie Lompré et al.   CIRCULATION

Sympathetic Stimulation of Adult Cardiomyocytes Requires Association of AKAP5 With a Subpopulation of L-Type Calcium Channels

(2010) C. Blake Nichols et al.   CIRCULATION RESEARCH

Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction

(2010) Barry A. Borlaug et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

 2-Adrenergic Receptor Redistribution in Heart Failure Changes cAMP Compartmentation

(2010) V. O. Nikolaev et al.   SCIENCE

Adenylyl cyclase type 5 protein expression during cardiac development and stress

(2009) Che-Lin Hu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Interval Training Normalizes Cardiomyocyte Function, Diastolic Ca 2+ Control, and SR Ca 2+ Release Synchronicity in a Mouse Model of Diabetic Cardiomyopathy

(2009) Tomas O. Stølen et al.   CIRCULATION RESEARCH

A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling

(2009) D. J. Fazakerley et al.   JOURNAL OF CELL SCIENCE

Morphological characteristics of cardiac calcium release units in animals with metabolic and circulatory disorders

(2009) Kelly F. McGrath et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart

(2009) A. R. Lyon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

(2008) Philip W. Raake et al.   CIRCULATION RESEARCH

Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca 2+ Channel Regulation in Adult Rat Ventricular Myocytes

(2008) Jérôme Leroy et al.   CIRCULATION RESEARCH

Effects of Ile164 Polymorphism of Beta2-Adrenergic Receptor Gene on Coronary Artery Disease

(2008) Federico Piscione et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adenylyl Cyclase Type 6 Deletion Decreases Left Ventricular Function via Impaired Calcium Handling

(2007) Tong Tang et al.   CIRCULATION