Article
Biochemistry & Molecular Biology
Francesca Keefe, Jimena Monzon-Sandoval, Anne E. Rosser, Caleb Webber, Meng Li
Summary: Inhibitory GABAergic interneurons originating in the embryonic medial ganglionic eminence (MGE) play a crucial role in controlling network activity in the neocortex. Dysfunctions in these cells are associated with seizure-based neurological disorders like epilepsy, autism, and schizophrenia. However, our understanding of the development of this diverse neuronal population is still incomplete. This study conducted single-cell RNA sequencing of human foetal MGEs and identified species-conserved transcriptomic profiles and potential transcription regulators for human interneuron differentiation, providing insights for in vitro modeling of interneuron development and potential therapeutic strategies using human pluripotent stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Audiology & Speech-Language Pathology
Maryanna S. Owoc, Maria E. Rubio, Brian Brockway, Srivatsun Sadagopan, Karl Kandler
Summary: This study investigated the survival and integration of transplanted MGE cells in the auditory center of mice with and without prior noise exposure. The results showed that transplanted MGE cells could survive, form synapses, and receive synaptic connections in the inferior colliculus (IC), suggesting that MGE cell transplantation may be a new strategy for treating central auditory pathologies following noise exposure.
Article
Neurosciences
Faez Siddiqi, Alexandria L. Trakimas, Donald J. Joseph, Margaret L. Lippincott, Eric D. Marsh, John H. Wolfe
Summary: Cortical interneurons are primarily derived from the medial and caudal ganglionic eminences during embryogenesis, with some contribution from the preoptic area, but a small population also originates from the lateral ganglionic eminence. Different populations of cells from various origins show both common and distinct lineage contributions towards the fate of cortical interneurons.
Article
Neurosciences
Anna Pancho, Manuela D. D. Mitsogiannis, Tania Aerts, Marco Dalla Vecchia, Lena K. K. Ebert, Lieve Geenen, Lut Noterdaeme, Ria Vanlaer, Anne Stulens, Paco Hulpiau, Katrien Staes, Frans Van Roy, Peter Dedecker, Bernhard Schermer, Eve Seuntjens
Summary: PCDH19 plays a crucial role in neuronal migration, and the dosage of PCDH19 is important for the migration process. Different subdomains of PCDH19 have different impacts on cell survival and migration.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Sam A. Booker, David J. A. Wyllie
Summary: NMDARs are essential for synaptic information transfer and plasticity in the majority of brain circuits. Inhibitory GABAergic interneurons exhibit diverse NMDAR expression and function, controlling cellular excitation in a synapse-specific manner. Further research is needed to fully understand the role of NMDARs in modulating GABAergic synaptic and circuit function.
Article
Developmental Biology
Shiona Biswas, C. Savio Chan, John L. R. Rubenstein, Lin Gan
Summary: The external globus pallidus (GPe) is crucial for controlling action, and changes in GPe neuron activity are associated with both passive and active body movements. Aberrant GPe neuron activity is linked to motor symptoms seen in Parkinson's Disease, Huntington's disease, and dystonia.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Mercedes F. Paredes, Cristina Mora, Quetzal Flores-Ramirez, Arantxa Cebrian-Silla, Ashley Del Dosso, Phil Larimer, Jiapei Chen, Gugene Kang, Susana Gonzalez Granero, Eric Garcia, Julia Chu, Ryan Delgado, Jennifer A. Cotter, Vivian Tang, Julien Spatazza, Kirsten Obernier, Jaime Ferrer Lozano, Maximo Vento, Julia Scott, Colin Studholme, Tomasz J. Nowakowski, Arnold R. Kriegstein, Michael C. Oldham, Andrea Hasenstaub, Jose Manuel Garcia-Verdugo, Arturo Alvarez-Buylla, Eric J. Huang
Summary: Research has revealed that the human embryonic ventral forebrain contains nests of proliferative neuroblasts which play a crucial role in generating a sufficient number of functional interneurons for the human brain.
Article
Neurosciences
Zhandong Li, Deling Wang, Wei Guo, Shiqi Zhang, Lei Chen, Yu-Hang Zhang, Lin Lu, XiaoYong Pan, Tao Huang, Yu-Dong Cai
Summary: This study predicts the diversity of cortical interneurons (CINs) in mouse embryos using single-cell transcriptomics and machine learning methods. By analyzing 2,669 single-cell transcriptome data, key genes are identified and powerful classifiers and classification rules are constructed. The findings provide valuable insights into the understanding of CIN diversity.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biology
Celia Biane, Florian Ruckerl, Therese Abrahamsson, Cecile Saint-Cloment, Jean Mariani, Ryuichi Shigemoto, David A. DiGregorio, Rachel M. Sherrard, Laurence Cathala
Summary: The study shows that the maturation of postsynaptic strength is uniformly reduced along the somatodendritic axis in interneurons, while dendritic integration remains sublinear. However, dendritic branching increases without changes in synapse density, resulting in a significant increase in distal inputs. Thus, changes in synapse distribution, rather than dendritic cable properties, are the main mechanism underlying the maturation of neuronal computation.
Article
Neurosciences
Rachel C. Bandler, Christian Mayer
Summary: The regulation of fate decisions in progenitor cells is crucial for the generation of neuronal diversity and the formation of specialized circuits with remarkable processing capacity.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Review
Neurosciences
Danping Li, Qiongfang Wu, Xiaohua Han
Summary: Excitatory projection neurons and inhibitory interneurons are the primary actors in the neural activity of the cerebral cortex, and an imbalance in excitatory-inhibitory neural networks can lead to neuropsychiatric diseases. Gamma-aminobutyric acid (GABA)ergic interneurons mediate inhibition and the embryonic medial ganglionic eminence (MGE) is a source of GABAergic interneurons. Transplanted MGE cells can migrate, differentiate into different subtypes of GABAergic interneurons, integrate into host neural circuits, enhance synaptic inhibition, and have potential application in diseases associated with interneuron disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Joseane Righes Marafiga, Scott C. Baraban
Summary: Impairment of inhibitory interneurons is a key feature of neurological disorders like epilepsy. Current treatment options involve drugs or deep brain stimulation, but a more effective strategy would be to add new inhibitory interneurons to pathological circuits. One promising approach is using MGE progenitor cells as a source of interneurons for transplantation, which has shown success in preclinical models of epilepsy. This article discusses the evolution of this therapy, particularly its adaptation for xenotransplantation in larger mammals.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Fong Kuan Wong, Martijn Selten, Claudia Roses-Novella, Varun Sreenivasan, Noemi Pallas-Bazarra, Eleni Serafeimidou-Pouliou, Alicia Hanusz-Godoy, Fazal Oozeer, Robert Edwards, Oscar Marin
Summary: This study investigates the mechanisms underlying developmental cell death in different populations of interneurons. The results show that neurogliaform cells and basket cells require glutamatergic transmission for survival, while the number of bipolar cells is regulated by serotonin signaling.
Article
Biology
Matthieu Genestine, Daisy Ambriz, Gregg W. Crabtree, Patrick Dummer, Anna Molotkova, Michael Quintero, Angeliki Mela, Saptarshi Biswas, Huijuan Feng, Chaolin Zhang, Peter Canoll, Gunnar Hargus, Dritan Agalliu, Joseph A. Gogos, Edmund Au
Summary: Cortical interneurons are inhibitory neurons in the brain cortex, and studies have shown that brain vasculature plays a critical role in regulating interneuron migration and maturation in both mice and humans.
Article
Biology
Jonas-Frederic Sauer, Marlene Bartos
Summary: This study reveals alterations in prefrontal circuit function in Disc1-mutant mice, including reduced firing rates of interneurons and decreased phase-coupling with gamma oscillations. Additionally, the study found decreased spike transmission efficacy in local pyramidal cell-interneuron connections, resulting in altered activation of assembly patterns.
Article
Neurosciences
Brian P. Grone, Scott C. Baraban
NATURE NEUROSCIENCE
(2015)
Article
Neurosciences
Joy Y. Sebe, Elizabeth Looke-Stewart, Scott C. Baraban
EXPERIMENTAL NEUROLOGY
(2014)
Article
Neurosciences
Joy Y. Sebe, Marina Bershteyn, Shinji Hirotsune, Anthony Wynshaw-Boris, Scott C. Baraban
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Neurosciences
Robert F. Hunt, Kelly M. Girskis, John L. Rubenstein, Arturo Alvarez-Buylla, Scott C. Baraban
NATURE NEUROSCIENCE
(2013)
Article
Neurosciences
Daniel Vogt, Robert F. Hunt, Shyamali Mandal, Magnus Sandberg, Shanni N. Silberberg, Takashi Nagasawa, Zhengang Yang, Scott C. Baraban, John L. R. Rubenstein
Article
Neurosciences
Amelia Stanco, Ramon Pla, Daniel Vogt, Yiran Chen, Shyamali Mandal, Jamie Walker, Robert F. Hunt, Susan Lindtner, Carolyn A. Erdman, Andrew A. Pieper, Steven P. Hamilton, Duan Xu, Scott C. Baraban, John L. R. Rubenstein
Article
Neurosciences
Joy Y. Sebe, Elizabeth Looke-Stewart, Matthew T. Dinday, Arturo Alvarez-Buylla, Scott C. Baraban
NEUROSCIENCE LETTERS
(2014)
Article
Multidisciplinary Sciences
Brian P. Grone, Maria Marchese, Kyla R. Hamling, Maneesh G. Kumar, Christopher S. Krasniak, Federico Sicca, Filippo M. Santorelli, Manisha Patel, Scott C. Baraban
Article
Multidisciplinary Sciences
Scott C. Baraban, Matthew T. Dinday, Gabriela A. Hortopan
NATURE COMMUNICATIONS
(2013)
Article
Multidisciplinary Sciences
SoonGweon Hong, Philip Lee, Scott C. Baraban, Luke P. Lee
SCIENTIFIC REPORTS
(2016)
Article
Neurosciences
Jui-Yi Hsieh, Scott C. Baraban
Article
Clinical Neurology
Aliesha Griffin, Kyla R. Hamling, Kelly Knupp, SoonGweon Hong, Luke P. Lee, Scott C. Baraban
Article
Neurosciences
Maneesh G. Kumar, Shane Rowley, Ruth Fulton, Matthew T. Dinday, Scott C. Baraban, Manisha Patel
Article
Neurosciences
Matthew T. Dinday, Scott C. Baraban