Application of Medial Ganglionic Eminence Cell Transplantation in Diseases Associated With Interneuron Disorders

Schizophrenia

(2022) Sameer Jauhar et al.   LANCET

Changes in Pre- and Postsurgery for Drug Resistant Epilepsy: Cognition and Sleep

(2022) Lihong Li et al.   Biomed Research International

Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes

(2021) Sangyep Shin et al.   Molecular Brain

Interneuron origins in the embryonic porcine medial ganglionic eminence

(2021) Mariana L. Casalia et al.   JOURNAL OF NEUROSCIENCE

GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer’s disease

(2021) Joan Jiménez-Balado et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

GABAergic deficits in absence of LPA1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus

(2021) Cristina Rosell-Valle et al.   Brain Structure & Function

Pharmacological and Therapeutic Approaches in the Treatment of Epilepsy

(2021) Shampa Ghosh et al.   Biomedicines

Lateralized Decrease of Parvalbumin+ Cells in the Somatosensory Cortex of ASD Models Is Correlated with Unilateral Tactile Hypersensitivity

(2021) Tara Deemyad et al.   CEREBRAL CORTEX

Development, Diversity, and Death of MGE-Derived Cortical Interneurons

(2021) Rhîannan H. Williams et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene therapy in epilepsy

(2021) Lu Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

The development of MGE-derived cortical interneurons: An Lhx6 tale

(2021) Ourania Christodoulou et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mouse and human share conserved transcriptional programs for interneuron development

(2021) Yingchao Shi et al.   SCIENCE

Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder

(2021) Rosalia Paterno et al.   Cell Reports

Electroacupuncture Promotes the Survival of the Grafted Human MGE Neural Progenitors in Rats with Cerebral Ischemia by Promoting Angiogenesis and Inhibiting Inflammation

(2021) Juan Li et al.   NEURAL PLASTICITY

Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission

(2020) Jie Zheng et al.   Cell Stem Cell

The role of GABAergic neural circuits in the pathogenesis of autism spectrum disorder

(2020) Jing Di et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Interneuron transplantation rescues social behavior deficits without restoring wild-type physiology in a mouse model of autism with excessive synaptic inhibition

(2020) Derek G. Southwell et al.   JOURNAL OF NEUROSCIENCE

AMPA receptor deletion in developing MGE-derived hippocampal interneurons causes a redistribution of excitatory synapses and attenuates postnatal network oscillatory activity

(2020) Gülcan Akgül et al.   Scientific Reports

Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer’s Disease

(2020) Ramsey Najm et al.   Cell Stem Cell

Neural Stem Cell Transplantation for Neurodegenerative Diseases

(2020) Roberta De Gioia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transplantation of GABAergic Interneuron Progenitor Attenuates Cognitive Deficits of Alzheimer’s Disease Model Mice

(2020) Mei-Hong Lu et al.   JOURNAL OF ALZHEIMERS DISEASE

Developmental Characterization of Zswim5 Expression in the Progenitor Domains and Tangential Migration Pathways of Cortical Interneurons in the Mouse Forebrain

(2020) Chuan‐Chie Chang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Shedding Light on Chandelier Cell Development, Connectivity, and Contribution to Neural Disorders

(2020) Nicholas B. Gallo et al.   TRENDS IN NEUROSCIENCES

Recent advances in gene therapy for neurodevelopmental disorders with epilepsy

(2020) Thomas J. Turner et al.   JOURNAL OF NEUROCHEMISTRY

Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery

(2020) Nishant Sinha et al.   NEUROLOGY

A Role for Somatostatin-Positive Interneurons in Neuro-Oscillatory and Information Processing Deficits in Schizophrenia

(2020) Alice B Van Derveer et al.   SCHIZOPHRENIA BULLETIN

Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer’s disease amyloidosis

(2019) Jan-Oliver Hollnagel et al.   PLoS One

Human Pluripotent Stem Cell-Derived Striatal Interneurons: Differentiation and Maturation In Vitro and in the Rat Brain

(2019) Zoe Noakes et al.   Stem Cell Reports

WNT/NOTCH Pathway Is Essential for the Maintenance and Expansion of Human MGE Progenitors

(2019) Lin Ma et al.   Stem Cell Reports

Excitatory-inhibitory imbalance in Alzheimer's disease and therapeutic significance

(2019) Eva Vico Varela et al.   NEUROBIOLOGY OF DISEASE

Direct Lineage Reprogramming for Brain Repair: Breakthroughs and Challenges

(2019) Rory Vignoles et al.   TRENDS IN MOLECULAR MEDICINE

Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies

(2019) Stephen J. Kaar et al.   JOURNAL OF NEURAL TRANSMISSION

Transplanted interneurons improve memory precision after traumatic brain injury

(2019) Bingyao Zhu et al.   Nature Communications

Region specific knockdown of Parvalbumin or Somatostatin produces neuronal and behavioral deficits consistent with those observed in schizophrenia

(2019) Stephanie M. Perez et al.   Translational Psychiatry

Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA

(2019) Zeinab Asgarian et al.   Stem Cell Reports

Alterations in cortical interneurons and cognitive function in schizophrenia

(2018) Samuel J. Dienel et al.   NEUROBIOLOGY OF DISEASE

Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism

(2018) Jennifer J. Donegan et al.   NEUROPSYCHOPHARMACOLOGY

Enhanced susceptibility to stress and seizures in GAD65 deficient mice

(2018) Jin Qi et al.   PLoS One

Anticonvulsant effects after grafting of rat, porcine, and human mesencephalic neural progenitor cells into the rat subthalamic nucleus

(2018) Bianca Backofen-Wehrhahn et al.   EXPERIMENTAL NEUROLOGY

The Epigenetic Factor CBP Is Required for the Differentiation and Function of Medial Ganglionic Eminence-Derived Interneurons

(2018) Alejandro Medrano-Fernández et al.   MOLECULAR NEUROBIOLOGY

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

(2018) Dinesh Upadhya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurobiological bases of autism-epilepsy comorbidity: a focus on excitation/inhibition imbalance

(2017) Yuri Bozzi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Genetic and activity-dependent mechanisms underlying interneuron diversity

(2017) Brie Wamsley et al.   NATURE REVIEWS NEUROSCIENCE

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

(2017) Hongjun Fu et al.   NEURON

Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer’s Disease

(2017) Rebecca P. Haberman et al.   Neurotherapeutics

Hippocampal GABAergic Inhibitory Interneurons

(2017) Kenneth A. Pelkey et al.   PHYSIOLOGICAL REVIEWS

Cryopreservation of GABAergic Neuronal Precursors for Cell-Based Therapy

(2017) Daniel Rodríguez-Martínez et al.   PLoS One

Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder

(2017) L A Ajram et al.   Translational Psychiatry

Transplanted Human Stem Cell-Derived Interneuron Precursors Mitigate Mouse Bladder Dysfunction and Central Neuropathic Pain after Spinal Cord Injury

(2016) Thomas M. Fandel et al.   Cell Stem Cell

The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Medial Prefrontal Cortex in Autism

(2016) Ezzat Hashemi et al.   CEREBRAL CORTEX

Medial Ganglionic Eminence Cells Freshly Obtained or Expanded as Neurospheres Show Distinct Cellular and Molecular Properties in Reducing Epileptic Seizures

(2016) Simone A. A. Romariz et al.   CNS Neuroscience & Therapeutics

Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition

(2016) William Mandy et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model

(2016) J J Donegan et al.   MOLECULAR PSYCHIATRY

GABA-ergic cell therapy for epilepsy: Advances, limitations and challenges

(2016) Ashok K. Shetty et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Interneuron Progenitor Transplantation to Treat CNS Dysfunction

(2016) Muhammad O. Chohan et al.   Frontiers in Neural Circuits

An interneuron progenitor maintains neurogenic potential in vivo and differentiates into GABAergic interneurons after transplantation in the postnatal rat brain

(2016) Qi Wang et al.   Scientific Reports

Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

(2015) Guillermo Gonzalez-Burgos et al.   BIOLOGICAL PSYCHIATRY

The Parvalbumin/Somatostatin Ratio Is Increased in Pten Mutant Mice and by Human PTEN ASD Alleles

(2015) Daniel Vogt et al.   Cell Reports

Prenatal Exposure to Autism-Specific Maternal Autoantibodies Alters Proliferation of Cortical Neural Precursor Cells, Enlarges Brain, and Increases Neuronal Size in Adult Animals

(2014) Verónica Martínez-Cerdeño et al.   CEREBRAL CORTEX

Transplantation of GABAergic Interneurons into the Neonatal Primary Visual Cortex Reduces Absence Seizures in Stargazer Mice

(2014) Mohamed Hammad et al.   CEREBRAL CORTEX

Inhibitory Interneuron Progenitor Transplantation Restores Normal Learning and Memory in ApoE4 Knock-In Mice without or with A  Accumulation

(2014) L. M. Tong et al.   JOURNAL OF NEUROSCIENCE

Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition

(2014) A. I. Gilani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interneurons from Embryonic Development to Cell-Based Therapy

(2014) D. G. Southwell et al.   SCIENCE

Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia

(2013) S M Perez et al.   MOLECULAR PSYCHIATRY

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

(2013) Vikram Pattanayak et al.   NATURE BIOTECHNOLOGY

Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits

(2013) Yan Liu et al.   NATURE BIOTECHNOLOGY

New insights into the classification and nomenclature of cortical GABAergic interneurons

(2013) Javier DeFelipe et al.   NATURE REVIEWS NEUROSCIENCE

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region

(2011) Alice Y. Wang et al.   ACTA NEUROPATHOLOGICA

Interneuron Progenitors Attenuate the Power of Acute Focal Ictal Discharges

(2011) Estanislao De la Cruz et al.   Neurotherapeutics

Hippocampal interneurons are abnormal in schizophrenia

(2011) Christine Konradi et al.   SCHIZOPHRENIA RESEARCH

Autism: A “Critical Period” Disorder?

(2011) Jocelyn J. LeBlanc et al.   NEURAL PLASTICITY

Embryonic MGE Precursor Cells Grafted into Adult Rat Striatum Integrate and Ameliorate Motor Symptoms in 6-OHDA-Lesioned Rats

(2010) Verónica Martínez-Cerdeño et al.   Cell Stem Cell

Transplant of GABAergic Precursors Restores Hippocampal Inhibitory Function in a Mouse Model of Seizure Susceptibility

(2010) I. Zipancic et al.   CELL TRANSPLANTATION

Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons

(2010) Bernardo Rudy et al.   Developmental Neurobiology

Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model

(2010) Maria E. Calcagnotto et al.   EPILEPSIA

The Largest Group of Superficial Neocortical GABAergic Interneurons Expresses Ionotropic Serotonin Receptors

(2010) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Biodistribution of Neural Stem Cells After Intravascular Therapy for Hypoxic–Ischemia

(2010) Arjun V. Pendharkar et al.   STROKE

Differential Targeting of the CA1 Subfield of the Hippocampal Formation by Schizophrenia and Related Psychotic Disorders

(2009) Scott A. Schobel et al.   ARCHIVES OF GENERAL PSYCHIATRY

A Loss of Parvalbumin-Containing Interneurons Is Associated with Diminished Oscillatory Activity in an Animal Model of Schizophrenia

(2009) D. J. Lodge et al.   JOURNAL OF NEUROSCIENCE

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

(2009) Jessica A. Cardin et al.   NATURE

Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice

(2009) S. C. Baraban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy

(2008) A. Knopp et al.   BRAIN

NKX2.1 specifies cortical interneuron fate by activating Lhx6

(2008) T. Du et al.   DEVELOPMENT